Exenatide Pharmacology


About Exenatide
Antidiabetic agent, New class agent
Mechanism of Action of Exenatide
Exenatide is an incretin mimic that acts as an agonist at glucagon-like peptide 1 (GLP-1) receptor. It increases glucose-dependent insulin secretion by the pancreatic beta-cells, suppresses inappropriately elevated glucagon secretion, increases beta-cell growth/replication, slows gastric emptying, and decreases food intake.
Pharmacokinets of Exenatide
Absorption: Absorbed after SC administration
Distribution: Widely distributed
Metabolism: Minimal Systemic Metabolism
Excretion: Excreted through urine
Onset of Action for Exenatide
Duration of Action for Exenatide
Half Life of Exenatide
2.4 hrs
Side Effects of Exenatide
5.Gastro-oesophageal reflux disease
6.Anaphylactic reaction
7.Decrease appetite
Contra-indications of Exenatide
Special Precautions while taking Exenatide
1.Renal impairment
2.GI diseases
3.Acute Pancreatitis
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Exenatide
Adjunct to Type 2 DM
Interactions for Exenatide
Paracetamol: Reduces the peak plasm level of paracetamol
Oral hypoglycaemic(Sulphonylureas): Lead to increase risk of hypoglycaemia
Warfarin: May enhance anticoagulant effect
Typical Dosage for Exenatide
Subcutaneous: Adult: Initial 5 mcg bid within 1 hr before morning and evening meals (or 2 main meals of the day). Doses should be at least 6 hr apart. May increase dose to 10 mcg bid after 1 mth based on response.
Schedule of Exenatide
Storage Requirements for Exenatide
Store unused exenatide pens in their original carton in the refrigerator protected from light. Once in use, store exenatide pens at room temperature (up to 77?F [25?C]) protected from light. Do not freeze. Keep out of the reach of children.
Effects of Missed Dosage of Exenatide
Effects of Overdose of Exenatide

Home Delivery for Exenatide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including exenatide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for exenatide and other medicines and health products. Home delivery services for exenatide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take exenatide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for exenatide before they complete the sale. You can get this information while placing the order for exenatide with the pharmacy.

Exenatide is a generic medicine name and there are several brands available for it. Some of the brands for exenatide might be better known than exenatide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have exenatide in stock, you can ask for one of the branded alternatives for exenatide.