Fluvastatin Pharmacology


About Fluvastatin
HMGCoA reductase inhibitor,Statins,Antilipemi agent
Mechanism of Action of Fluvastatin
Fluvastatin selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, the rate-limiting step in cholesterol biosynthesis. Inhibition results in a decrease in hepatic cholesterol levels which stimulates the synthesis of LDL receptors and increases hepatic uptake of LDL cholesterol. The end result is decreased levels of plasma total and LDL cholesterol.
Pharmacokinets of Fluvastatin
Absorption: Rapidly and completely absorbed from the GI tract
Distribution: >98% bound to plasma proteins
Metabolism: Extensive 1st-pass metabolism in the liver
Excretion: About 90% (faeces) and about 6% (urine)
Onset of Action for Fluvastatin
Duration of Action for Fluvastatin
Half Life of Fluvastatin
1 to 3 hrs
Side Effects of Fluvastatin
1.GI disturbances
3.Skin rashes
5.Blurred vision
Contra-indications of Fluvastatin
1.Acute liver disease
Special Precautions while taking Fluvastatin
1.Liver disease
2.High alcohol intake
3.Unexplained muscle pain
4.Severe renal impairment
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Below 9 yrs: Contraindicated
Indications for Fluvastatin
Interactions for Fluvastatin
Bleeding and increased prothrombin time with coumarin anticoagulants
Typical Dosage for Fluvastatin
Adult: Initial dose: 20 to 40 mg orally once a day at bedtime.
Maintenance dose: 20 to 80 mg/day
Children: 9 to 16 yrs: Initial dose: 20 mg orally once a day at bedtime.
Maintenance dose: 20 to 80 mg/day
Schedule of Fluvastatin
Storage Requirements for Fluvastatin
Store in a well closed container at room temperature, below 30 degree celcius. Protect from sunlight and heat. Keep out of the reach of children
Effects of Missed Dosage of Fluvastatin
Effects of Overdose of Fluvastatin

Home Delivery for Fluvastatin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluvastatin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluvastatin and other medicines and health products. Home delivery services for fluvastatin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fluvastatin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluvastatin before they complete the sale. You can get this information while placing the order for fluvastatin with the pharmacy.

Fluvastatin is a generic medicine name and there are several brands available for it. Some of the brands for fluvastatin might be better known than fluvastatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluvastatin in stock, you can ask for one of the branded alternatives for fluvastatin.