METHYLENE BLUE Pharmacology

METHYLENE BLUE

About METHYLENE BLUE
Synthetic origin, Antidotes
Mechanism of Action of METHYLENE BLUE
Methylthioninium chloride (methylene blue) lowers methaemoglobin levels in the RBCs through activation of reductase enzyme capable of reducing methylene blue to leucomethylene blue, which in turn reduces methaemoglobin to haemoglobin. Methylthioninium chloride blocks calcium binding by oxalate and by organic stone matrix. It also reduces the tendency of calcium oxalate crystals to aggregate by acting as a crystal poison at the interface. It is a weak antiseptic at low concentrations
Pharmacokinets of METHYLENE BLUE
Absorption: Absorbed after orally or parentrally
Metabolism: Undergoes reduction to leucomethylene in the tissues
Excretion: Mainly excreted through urine, some is excreted via bile
Onset of Action for METHYLENE BLUE
Reduction of methaemoglobin: 30-60 min (IV)
Duration of Action for METHYLENE BLUE
N/A
Half Life of METHYLENE BLUE
N/A
Side Effects of METHYLENE BLUE
1.Imparts a blue colour to saliva,Urine, Faeces and Skin
2.Nausea
3.Vomiting
4.Abdominal and chest pain
5.Headache
6.Dizziness
7.Mental confusion
Contra-indications of METHYLENE BLUE
1.G6PD Deficiency
2.Renal impairment
Special Precautions while taking METHYLENE BLUE
1.Kidney disease
2.Blood disorder
3.Any allergy
Pregnancy Related Information
May be used
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Neonates: Contraindicated
Indications for METHYLENE BLUE
Methemoglobinemia
Interactions for METHYLENE BLUE
N/A
Typical Dosage for METHYLENE BLUE
Oral:Maintenance therapy in chronic methemoglobinemia: 100-300 mg daily
Minor UTI and for prevention of urinary oxalate stones formation: 65-130 mg tid. Max dose: 390 mg/day
Schedule of METHYLENE BLUE
N/A
Storage Requirements for METHYLENE BLUE
Store below 40 degree celcius. Protect from sunlight, moisture and heat. Keep out of the reach of children
Effects of Missed Dosage of METHYLENE BLUE
N/A
Effects of Overdose of METHYLENE BLUE
N/A

Home Delivery for METHYLENE BLUE in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including methylene blue.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for methylene blue and other medicines and health products. Home delivery services for methylene blue may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take methylene blue only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for methylene blue before they complete the sale. You can get this information while placing the order for methylene blue with the pharmacy.

METHYLENE BLUE is a generic medicine name and there are several brands available for it. Some of the brands for methylene blue might be better known than methylene blue itself. If the pharmacy that's willing to deliver medicines to your home doesn't have methylene blue in stock, you can ask for one of the branded alternatives for methylene blue.