OXYCODONE Pharmacology

OXYCODONE

About OXYCODONE
Phenanthrene derivative, Opiate agonist
Mechanism of Action of OXYCODONE
Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability
Pharmacokinets of OXYCODONE
Absorption: Absorbed after oral, Intravenously, Subcutaneously, Rectally, Intranasaly
Distribution: Protein binding 45 %
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for OXYCODONE
N/A
Duration of Action for OXYCODONE
N/A
Half Life of OXYCODONE
N/A
Side Effects of OXYCODONE
1.Hallucinations
2.Nausea
3.Vomiting
4.Constipation
5.Respiratory depression
6.Hypotension
Contra-indications of OXYCODONE
1.Respiratory depression
2.Liver damage
3.Peptic ulcer
4.Bleeding
5.Hypersensitivity to the drug
Special Precautions while taking OXYCODONE
1.Hepatic impairment
2.Renal impairment
3.Hypothyroidism
4.Asthma
5.Convulsive disorders
6.Inflammatory or obstructive bowel disease
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Neonates: Contraindicated
Indications for OXYCODONE
Moderate to severe pain
Interactions for OXYCODONE
May potentiate effects of TCAs
Increased risk of serotonin syndrome with serotonergic drugs
Sedative effects may be increased by metoclopramide
Antagonises efficacy of diuretics
Effects may be reduced by rifampicin, amiodarone, quinidine, polycyclic antidepressants
Typical Dosage for OXYCODONE
Oral: Initially, 5 mg every 4-6 hr increased according to individual requirements. Extended-release preparation should be taken 12 hrly. Usual max dose 400 mg daily
Intravenous: As inj: 1-10 mg over 1-2 min every 4 hr if required. As IV infusion: starting dose of 2 mg/hr increased as necessary
Subcutaneous: As inj: Initially, 5 mg every 4 hr if required or as infusion: 7.5 mg/24 hr, adjusted according to response
Rectal: As pectinate: 30 mg suppository every 6-8 hr. As hydrochloride: 10-40 mg suppository every 6-8 hr
Schedule of OXYCODONE
N/A
Storage Requirements for OXYCODONE
Store in a well closed container at room temperature. Protect from sunlight. Keep out of the reach of children
Effects of Missed Dosage of OXYCODONE
N/A
Effects of Overdose of OXYCODONE
N/A

Home Delivery for OXYCODONE in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxycodone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxycodone and other medicines and health products. Home delivery services for oxycodone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxycodone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxycodone before they complete the sale. You can get this information while placing the order for oxycodone with the pharmacy.

OXYCODONE is a generic medicine name and there are several brands available for it. Some of the brands for oxycodone might be better known than oxycodone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxycodone in stock, you can ask for one of the branded alternatives for oxycodone.