- Medicine India
- Generic Medicines
- Pharmacology For PIMECROLIMUS
PIMECROLIMUSAbout PIMECROLIMUSImmunomodulator, Macrolactam and is a derivative of ascomycinMechanism of Action of PIMECROLIMUSPimecrolimus binds with high affinity to macrophilin-12 (FKBP-12) and inhibits the calcium-dependent phosphatase, calcineurin. As a consequence, it inhibits T cell activation by blocking the transcription of early cytokines. In particular, pimecrolimus inhibits at nanomolar concentrations Interleukin-2 and interferon gamma (Th1-type) and Interleukin-4 and Interleukin-10 (Th2-type) cytokine synthesis in human T cells. Also, pimecrolimus prevents the release of inflammatory cytokines and mediators from mast cells in vitro after stimulation by antigen/lgEPharmacokinets of PIMECROLIMUSAbsorption: Absorbed after topical administration
Distribution: 74-87% bound to plasma proteins
Metabolism: Metabolised in the liver
Excretion: 80% of the drug is excreted in the feces
Onset of Action for PIMECROLIMUSN/ADuration of Action for PIMECROLIMUSN/AHalf Life of PIMECROLIMUSN/ASide Effects of PIMECROLIMUS1.Upper respiratory tract infection
3.Nasopharyngitis and Headache
Contra-indications of PIMECROLIMUSHypersensitivity to the drugSpecial Precautions while taking PIMECROLIMUS1.Renal impairment
3.Avoid contact with the eyes and mucous membranes
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related Information<2 yr: ContraindicatedIndications for PIMECROLIMUSAtopic dermatitisInteractions for PIMECROLIMUSIncreased risk of infections when used with live vaccinesTypical Dosage for PIMECROLIMUSAs 1% cream: Apply a thin layer onto the affected areas bidSchedule of PIMECROLIMUSN/AStorage Requirements for PIMECROLIMUSStore at 15-30?C in a well closed container. Keep out of the reach of childEffects of Missed Dosage of PIMECROLIMUSN/AEffects of Overdose of PIMECROLIMUSN/A
Home Delivery for PIMECROLIMUS in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pimecrolimus.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pimecrolimus and other medicines and health products. Home delivery services for pimecrolimus may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take pimecrolimus only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pimecrolimus before they complete the sale. You can get this information while placing the order for pimecrolimus with the pharmacy.
PIMECROLIMUS is a generic medicine name and there are several brands available for it. Some of the brands for pimecrolimus might be better known than pimecrolimus itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pimecrolimus in stock, you can ask for one of the branded alternatives for pimecrolimus.