SEVOFLURANE Pharmacology

SEVOFLURANE

About SEVOFLURANE
Volatile Halogenated anaesthetics, sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether
Mechanism of Action of SEVOFLURANE
Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor
Pharmacokinets of SEVOFLURANE
Absorption: Absorbed on inhalation
Distribution: Crosses placenta
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for SEVOFLURANE
Within 2 minutes
Duration of Action for SEVOFLURANE
4-14 minutes
Half Life of SEVOFLURANE
15 to 23 hrs
Side Effects of SEVOFLURANE
N/A
Contra-indications of SEVOFLURANE
1.Malignant hyperthermia
2.Hypersensitivity
Special Precautions while taking SEVOFLURANE
1.Cardiac impairment
2.Respiratory impairment
3.Renal impairment
4.Hepatic impairment
5.Coronary Artery disease
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for SEVOFLURANE
Induction and maintenance of general anaesthesia
Interactions for SEVOFLURANE
May enhance effect and duration of competitive neuromuscular blockers
Metabolism and toxicity increased by cytochrome P450 isoenzyme CYP2E1 inducers including isoniazid and alcohol
Increased risk of cardiac arrhythmias when used with epinephrine or norepinephrine
Typical Dosage for SEVOFLURANE
Adult: Given via a calibrated vaporiser: Induction: Up to 5% v/v with oxygen or a mixture of oxygen and nitrous oxide
Maintenance: 0.5-3% v/v with or without nitrous oxide
Child: Given via a calibrated vaporiser: Induction: Up to 7% v/v
Maintenance: 0.5-3% v/v with or without nitrous oxide
Schedule of SEVOFLURANE
N/A
Storage Requirements for SEVOFLURANE
Store in a well closed, at room temperature. Protect from heat. Keep out of the reach of children ..
Effects of Missed Dosage of SEVOFLURANE
N/A
Effects of Overdose of SEVOFLURANE
N/A

Home Delivery for SEVOFLURANE in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sevoflurane.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sevoflurane and other medicines and health products. Home delivery services for sevoflurane may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sevoflurane only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sevoflurane before they complete the sale. You can get this information while placing the order for sevoflurane with the pharmacy.

SEVOFLURANE is a generic medicine name and there are several brands available for it. Some of the brands for sevoflurane might be better known than sevoflurane itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sevoflurane in stock, you can ask for one of the branded alternatives for sevoflurane.