SITAGLIPTIN Pharmacology


Antidiabetic agent, Oral hypoglycaemic
Mechanism of Action of SITAGLIPTIN
Vildagliptin is a dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycaemic control by preventing DPP-4 from inactivating the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus prolonging incretin activity in response to ingestion of nutrients. This increases insulin sensitivity, decreases glucagon secretion and improves ?-cell function.
Pharmacokinets of SITAGLIPTIN
Absorption: Absorbed after oral administration
Distribution: Protein binding 38 %
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for SITAGLIPTIN
Duration of Action for SITAGLIPTIN
8 to 14 hrs
Side Effects of SITAGLIPTIN
3.Hypersensitivity reactions

Contra-indications of SITAGLIPTIN
1.Hypersensitivity reactions
2.Diabetic ketoacidosis
4.Severe infections
Special Precautions while taking SITAGLIPTIN
Kidney disease
Pregnancy Related Information
May be used
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Indications for SITAGLIPTIN
Type 2 Diabetes mellitus
Interactions for SITAGLIPTIN
Digoxin: Increase concentration of digoxin
Increased risk of hypoglycaemia when used with other anti-diabetic agents
Typical Dosage for SITAGLIPTIN
100 mg orally once daily
Storage Requirements for SITAGLIPTIN
Store in a well closed container. Keep out of the reach of children.
Effects of Missed Dosage of SITAGLIPTIN
Effects of Overdose of SITAGLIPTIN

Home Delivery for SITAGLIPTIN in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sitagliptin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sitagliptin and other medicines and health products. Home delivery services for sitagliptin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sitagliptin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sitagliptin before they complete the sale. You can get this information while placing the order for sitagliptin with the pharmacy.

SITAGLIPTIN is a generic medicine name and there are several brands available for it. Some of the brands for sitagliptin might be better known than sitagliptin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sitagliptin in stock, you can ask for one of the branded alternatives for sitagliptin.