TELITHROMYCIN Pharmacology

TELITHROMYCIN

About TELITHROMYCIN
Ketolides, Erythromycin derivative
Mechanism of Action of TELITHROMYCIN
Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S
Pharmacokinets of TELITHROMYCIN
Absorption: Absorbed after oral administration
Distribution: Protein binding 60 to 70 %
Metabolism: Metabolised in the liver
Excretion: Excreted through urine and bile
Onset of Action for TELITHROMYCIN
N/A
Duration of Action for TELITHROMYCIN
N/A
Half Life of TELITHROMYCIN
10 hrs
Side Effects of TELITHROMYCIN
1.Diarrhea
2.Nausea
4.Headache
5.Dizziness
6.Blurred vision
Contra-indications of TELITHROMYCIN
1.Hypersensitivity to macrolide]
2.History of Hepatitis
Special Precautions while taking TELITHROMYCIN
1.Hepatic impairment
2.Renal impairment
3.Cardiac problem
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for TELITHROMYCIN
1.Community acquired pneumonia
2.Acute sinusitis
3.Bacterial tonsillitis
4.Acute bronchitis
Interactions for TELITHROMYCIN
Concurrent use may increase plasma concentrations of digoxin, sirolimus, midazolam, metoprolol, tacrolimus, ciclosporin
Decrease plasma concentrations of sotalol
Increased nausea and vomiting with theophylline
Increased telithromycin levels with ketoconazole, itraconazole
Decreased telithromycin levels with rifampicin
Increased ergot toxicity with ergot alkaloid derivatives
Typical Dosage for TELITHROMYCIN
800 mg once daily
Schedule of TELITHROMYCIN
N/A
Storage Requirements for TELITHROMYCIN
Store at 15-30?C in a well closed container. Keep out of the reach of children
Effects of Missed Dosage of TELITHROMYCIN
N/A
Effects of Overdose of TELITHROMYCIN
N/A

Home Delivery for TELITHROMYCIN in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including telithromycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for telithromycin and other medicines and health products. Home delivery services for telithromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take telithromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for telithromycin before they complete the sale. You can get this information while placing the order for telithromycin with the pharmacy.

TELITHROMYCIN is a generic medicine name and there are several brands available for it. Some of the brands for telithromycin might be better known than telithromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have telithromycin in stock, you can ask for one of the branded alternatives for telithromycin.