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- Pharmacology For Dicyclomine + Ethyl morphine
Dicyclomine + Ethyl morphine Pharmacology
Dicyclomine + Ethyl morphine
About Dicyclomine + Ethyl morphineN/AMechanism of Action of Dicyclomine + Ethyl morphineN/APharmacokinets of Dicyclomine + Ethyl morphineN/AOnset of Action for Dicyclomine + Ethyl morphineN/ADuration of Action for Dicyclomine + Ethyl morphineN/AHalf Life of Dicyclomine + Ethyl morphineN/ASide Effects of Dicyclomine + Ethyl morphineN/AContra-indications of Dicyclomine + Ethyl morphineN/ASpecial Precautions while taking Dicyclomine + Ethyl morphineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dicyclomine + Ethyl morphineN/AInteractions for Dicyclomine + Ethyl morphineN/ATypical Dosage for Dicyclomine + Ethyl morphineN/ASchedule of Dicyclomine + Ethyl morphineN/AStorage Requirements for Dicyclomine + Ethyl morphineN/AEffects of Missed Dosage of Dicyclomine + Ethyl morphineN/AEffects of Overdose of Dicyclomine + Ethyl morphineN/ADicyclomine
About DicyclomineAnticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.Mechanism of Action of DicyclomineDicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.Pharmacokinets of DicyclomineAbsorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine1-2 hours.Duration of Action for Dicyclomine4-6 hours.Half Life of Dicyclomine1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))Side Effects of Dicyclomine1.Constipation
2.Dry mouth
3.Nausea
4.Vomiting
5.Abdominal discomfort
6.Headache
7.Dizziness
8.Confusion
9.Palpitations
10.Tachycardia
11.Increased intraocular pressure
12.Mydriasis
13.Urine retention
14.Urinary hesitancy
15.Decreased sweating
Contra-indications of Dicyclomine1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Obstructive uropathy
5.Reflux oesophagitis
6.Severe ulcerative colitis
7.Myasthenia gravis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Prostatic hypertrophy
5.Hiatus hernia associated
6.Hyperthyroidism
7.Autonomic neuropathy
8.Ulcerative colitis
9.Arrhythmia
10.Hypertension
11.Coronary artery disease
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationUse with caution.
NEONATES: contraindicatedIndications for Dicyclomine1. Irritable bowel syndrome
2.Colicky pain
Interactions for DicyclomineN/ATypical Dosage for DicyclomineAdult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Children:
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of DicyclomineHStorage Requirements for DicyclomineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of DicyclomineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DicyclomineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.Ethyl Morphine
About Ethyl MorphineOpioids , Antitussive ,Analgesic.Mechanism of Action of Ethyl MorphineEthylmorphine exerts it`s action through opioid receptors and posses antitussive properties. It directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptorsPharmacokinets of Ethyl MorphineAbsorption: Well absorbed orally.Metabolism: It is converted in to Morphine and norethylmorphine in the body.Onset of Action for Ethyl MorphineN/ADuration of Action for Ethyl MorphineN/AHalf Life of Ethyl MorphineN/ASide Effects of Ethyl Morphine1. Constipation
2. Nausea
3. Vomiting
4. Drymouth
5. Respiratory depression
6. Hypotension
7. Bradycardia
8. Dizziness
9. Sedation
10. Euphoria
11. Urine retention
12. Flushing
13. Pruritus
14. Diaphoresis
15. Physical dependence
16. Hepatic impairment
17. Renal impairment
18. Thrombocytopenia
19. Change in libido
20. Miosis
21. Altered glucose tolerance
Contra-indications of Ethyl Morphine1. Hypersensitivity to the drug
2. Respiratory insufficiency
3. Cough accompanied by expectorations
4. Paralytic ileus
5. Head injury
Special Precautions while taking Ethyl Morphine1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
4. Hypothyroidism
5. COPD
6. In deliberate individuals
7. Prostatic hypertrophy
8. Epilepsy
9. The duration of the treatment should be as small as possible
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 8 years: Contraindicated
Indications for Ethyl Morphine1. As antitussiveInteractions for Ethyl MorphineN/ATypical Dosage for Ethyl MorphineOral:
Adults: 10 to 15mg 3 to 4 times daily up to 50mg/day.
Maximum dose: 100mg/day
Children (age 8 to 14): 15 to 30mg daily as equally divided doses.Maximum dose:5mg/10kg/day.
Schedule of Ethyl MorphineN/AStorage Requirements for Ethyl MorphineStore at controlled room temperature at a range of 15 to 30 degree C.Effects of Missed Dosage of Ethyl MorphineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ethyl MorphineEstablish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression; use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.
Home Delivery for Dicyclomine + Ethyl morphine in Your City
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Dicyclomine + Ethyl morphine is a generic medicine name and there are several brands available for it. Some of the brands for dicyclomine + ethyl morphine might be better known than dicyclomine + ethyl morphine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicyclomine + ethyl morphine in stock, you can ask for one of the branded alternatives for dicyclomine + ethyl morphine.
