- Medicine India
- Generic Medicines
- Pharmacology For Levodopa + Carbidopa + Entacapone
Levodopa + Carbidopa + Entacapone Pharmacology
Levodopa + Carbidopa + EntacaponeAbout Levodopa + Carbidopa + EntacaponeN/AMechanism of Action of Levodopa + Carbidopa + EntacaponeLevodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa. Entacapone is a selective inhibitor of catechol-o-methyltransferase. Given concurrently, entacapone results in greater and more substained plasma levels of levodopa, leading to greater control of parkinsonism symptomsPharmacokinets of Levodopa + Carbidopa + EntacaponeN/AOnset of Action for Levodopa + Carbidopa + EntacaponeN/ADuration of Action for Levodopa + Carbidopa + EntacaponeN/AHalf Life of Levodopa + Carbidopa + EntacaponeN/ASide Effects of Levodopa + Carbidopa + EntacaponeN/AContra-indications of Levodopa + Carbidopa + EntacaponeN/ASpecial Precautions while taking Levodopa + Carbidopa + EntacaponeN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Levodopa + Carbidopa + EntacaponeParkinson?s DiseaseInteractions for Levodopa + Carbidopa + EntacaponeIncreased risk of postural hypotension when used concurrently with hypotensive drugs
Dopamine D2 receptor antagonists, phenytoin or papaverine may reduce the efficacy of levodopa
Iron salts may reduce the bioavailability
Typical Dosage for Levodopa + Carbidopa + EntacaponeOptimum dosage must be carefully titrated according to patient's response
Initial: 1 tab/day. Max: 8 tabs/day
Schedule of Levodopa + Carbidopa + EntacaponeN/AStorage Requirements for Levodopa + Carbidopa + EntacaponeN/AEffects of Missed Dosage of Levodopa + Carbidopa + EntacaponeN/AEffects of Overdose of Levodopa + Carbidopa + EntacaponeN/A
LevodopaAbout LevodopaDopamine agonist, Antiparkinsonian agent.Mechanism of Action of LevodopaLevodopa is the precursor of Dopamine.Levodopa crosses the blood brain barrier and undergoes decarboxylation and releases Dopamine. The Dopamine stimulates dopaminergic receptors in the basal ganglia and enhances the balance between cholinergic and dopaminergic activity and results in improved modulation of voluntary nerve impulses transmitted to the motor cortex.Pharmacokinets of LevodopaAbsorption: It is absorbed rapidly from the small intestine. Distribution: It is widely distributed in most body tissue.It crosses blood brain barrier and also distribute in the milk. Metabolism: About 95% of the drug is converted to Dopamine by l-aromatic amino acid decarboxylase enzyme.Excretion:It is excreted mainly through urine.Onset of Action for LevodopaN/ADuration of Action for Levodopa5 hourHalf Life of Levodopa1 - 3 hoursSide Effects of Levodopa1.Vomiting
Contra-indications of Levodopa1.Hypersensitivity to the drug
2.Concurrent therapy with MAO inhibitors within 14days
3.Acute angle closure glaucoma
Special Precautions while taking Levodopa1.Severe renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 12 years:ContraindicatedIndications for Levodopa1.ParkinsonismInteractions for LevodopaN/ATypical Dosage for LevodopaInitial dose: 0.5 - 1 g daily in 2 - 4 divided doses with food. Increase 100 - 750mg daily every 3 - 7 days. Maximum dose: 8 g/daySchedule of LevodopaHStorage Requirements for LevodopaStore at 25 - 30 degree C in a tightly closed container.Effects of Missed Dosage of LevodopaTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of LevodopaGive supportive measures and symptomatic treatment.Drug can be removed from the body by gastric lavage. To reverse the toxic and therapeutic effect of Levodopa Pyridoxine 10 - 25 mg can be given.
CarbidopaAbout CarbidopaA noncompetitive DOPA decarboxylase inhibitor, Antidyskinetics, Anti-Parkinson`s Agent.Mechanism of Action of CarbidopaCarbidopa inhibits the peripheral decarboxylation of Levodopa and thus slowing its conversion to Dopamine in extra cerebral tissues. This results in an increased availability of Levodopa for transport to the brain and undergoes decarboxylation to Dopamine in the brain. Carbidopa increases the concentration of Levodopa in the brain.Pharmacokinets of CarbidopaAbsorption: About 40 - 70% of the drug is absorbed after oral administration. Distribution: It is widely distributed in body tissues except the CNS. It is also distributed into breast milk. Excretion: It is excreted unchanged in urine.Onset of Action for CarbidopaN/ADuration of Action for CarbidopaN/AHalf Life of Carbidopa1 - 2 hoursSide Effects of Carbidopa1.Vomiting
Contra-indications of Carbidopa1.Hypersensitivity to the drug
2.Concurrent therapy with MAO inhibitors within 14days
3.Acute angle closure glaucoma
Special Precautions while taking Carbidopa1.Severe renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 12 years:ContraindicatedIndications for Carbidopa1.ParkinsonismInteractions for CarbidopaN/ATypical Dosage for CarbidopaCarbidopa is usually given with Levodopa.Dose is 70 - 100 mg to suppress peripheral decarboxylation of Levodopa.Schedule of CarbidopaHStorage Requirements for CarbidopaStore at 25 - 30 degree C in a tightly closed container.Effects of Missed Dosage of CarbidopaTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of CarbidopaGive supportive measures and symptomatic treatment.
EntacaponeAbout EntacaponeCOMT Inhibitor, Systemic Anti-Parkinson`s Agent.Mechanism of Action of EntacaponeEntacapone is a peripherally acting Catechol O-methyl transferase (COMT) inhibitor. Entacapone block the O- methylation of Levodopa and increases the fraction of the drug available for delivery to the brain. This will result in increased concentration of dopamine and is useful in Parkinsonism.Pharmacokinets of EntacaponeAbsorption: Entacapone is rapidly absorbed after oral administration and the bioavailability is only 35%. Distribution: It is distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: It is excreted mainly in faeces and only a small amount in urine.Onset of Action for Entacapone10 - 20 minutesDuration of Action for Entacapone2 hoursHalf Life of Entacapone3 - 5 hoursSide Effects of Entacapone1.Nausea
Contra-indications of Entacapone1.Hypersensitivity to EntacaponeSpecial Precautions while taking Entacapone1.Renal impairment
3.Patient on monoamine oxidase inhibitor therapy
4.Use caution when driving vehicle, operating machine or involving in any hazardous activities
6.Slowly withdraw the drug with caution
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated.
NEONATES: contraindicatedIndications for Entacapone1. Adjunct to Levodopa or Carbidopa for the treatment of idiopathic Parkinson`s disease
Interactions for EntacaponeNo interaction of entacapone with carbidopa has been observed with the recommended treatment schedule. The experience of the clinical use of entacapone with several drugs, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine, and medicinal products that are metabolised by COMT is limited.
Typical Dosage for EntacaponeAdult: 200 mg with Carbidopa or Levodopa
Maximum daily dose: 1600 mg / day
Schedule of EntacaponeN/AStorage Requirements for EntacaponeStore at 15 - 30 degree C. Protect from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of EntacaponeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of EntacaponeGive supportive measures and symptomatic treatment. Gastric lavage can be done to increase the elimination of the drug. Activated charcoal is given to reduce the absorption of the drug.
Home Delivery for Levodopa + Carbidopa + Entacapone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levodopa + carbidopa + entacapone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levodopa + carbidopa + entacapone and other medicines and health products. Home delivery services for levodopa + carbidopa + entacapone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take levodopa + carbidopa + entacapone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levodopa + carbidopa + entacapone before they complete the sale. You can get this information while placing the order for levodopa + carbidopa + entacapone with the pharmacy.
Levodopa + Carbidopa + Entacapone is a generic medicine name and there are several brands available for it. Some of the brands for levodopa + carbidopa + entacapone might be better known than levodopa + carbidopa + entacapone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levodopa + carbidopa + entacapone in stock, you can ask for one of the branded alternatives for levodopa + carbidopa + entacapone.