Hydrocortisone + Lidocaine + Zinc Oxide Pharmacology

Hydrocortisone + Lidocaine + Zinc Oxide

About Hydrocortisone + Lidocaine + Zinc Oxide
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Mechanism of Action of Hydrocortisone + Lidocaine + Zinc Oxide
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Pharmacokinets of Hydrocortisone + Lidocaine + Zinc Oxide
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Onset of Action for Hydrocortisone + Lidocaine + Zinc Oxide
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Duration of Action for Hydrocortisone + Lidocaine + Zinc Oxide
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Half Life of Hydrocortisone + Lidocaine + Zinc Oxide
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Side Effects of Hydrocortisone + Lidocaine + Zinc Oxide
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Contra-indications of Hydrocortisone + Lidocaine + Zinc Oxide
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Special Precautions while taking Hydrocortisone + Lidocaine + Zinc Oxide
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Hydrocortisone + Lidocaine + Zinc Oxide
1.Hemorrhoids
2.Pruritus ani
3.Proctitis
4.Anal Fissures
5.Post-op pain relief
Interactions for Hydrocortisone + Lidocaine + Zinc Oxide
N/A
Typical Dosage for Hydrocortisone + Lidocaine + Zinc Oxide
Insert 1 supp morning & night after each defecation. Max: 5 supp/day
Schedule of Hydrocortisone + Lidocaine + Zinc Oxide
N/A
Storage Requirements for Hydrocortisone + Lidocaine + Zinc Oxide
30 months if stored in a refrigerator (2?C-8?C). Do not freeze. 2 months if stored not above 25?C. Keep out of the reach of children
Effects of Missed Dosage of Hydrocortisone + Lidocaine + Zinc Oxide
N/A
Effects of Overdose of Hydrocortisone + Lidocaine + Zinc Oxide
N/A

Hydrocortisone

About Hydrocortisone
Systemic synthetic glucocorticoid, anti-inflammatory
Mechanism of Action of Hydrocortisone
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts both glucocorticoid and mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.

Pharmacokinets of Hydrocortisone
Absorption: Absorption ranges from 1% to 36% after topical application. Absorption after injection varies depending up on the site of injection and blood supply to particular area.
Distribution: After topical application distributed throughout the local skin layers. Any drug absorbed in to circulation is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine. Metabolism: Metabolized primarily in skin after topical application and a small amount absorbed in to circulation is metabolized in liver. Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Hydrocortisone
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Duration of Action for Hydrocortisone
N/A
Half Life of Hydrocortisone
N/A
Side Effects of Hydrocortisone
1. Burning
2. Irritation
3. Pruritus
4. Dryness
5. Erythema
6. Folliculitis
7. Hypertrichosis
8. Acneiform eruptions
9. Allergic contact dermatitis
10. Secondary infections
11. Atrophy
12. Striae
13. Suppression of adrenocorticotropic hormone
14. Cushing`s syndrome
15. Glucosuria
16. Hyperglycaemia
17. Fluid retention
18. Sodium retention
19. Hypokalaemia
20. Oedema
21. Weakness
22. Muscle wasting
23. Gastrointestinal discomfort
24. Peptic ulcer
25. Haemorrhage
26. Joint damage
27. Fibrosis
28. Headache
29. Convulsions
30. Vertigo
31. Increased intracranial pressure
32. Depression
33. Local hypopigmentation

Contra-indications of Hydrocortisone
1. Hypersensitivity to the drug
2. Not to be given I.V. or I.M.
3. Local or systemic infections
4. Fungal or herpetic keratitis
5. Cataract
6. Tubercular or syphilitic lesions.

Special Precautions while taking Hydrocortisone
1. Occlusive dressings (Topical preparation)
2. Use of potent preparations should be short term or intermittent
3. Milder drugs should be used in acute lesions and stronger ones are for chronic lesions
4. Avoid sudden discontinuation of the drug
5. Hypothyroidism
6. Cirrhosis
7. Stress
8. Sepsis
9. Ocular herpes simplex
10. Peptic ulcer
11. Hypertension
12. Osteoporosis
13. Myasthenia gravis
14. Renal impairment
15. Ulcerative colitis
16. Diverticulitis
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated

Indications for Hydrocortisone
Intra-articular injection :
1. Rheumatoid arthritis
2. Gouty arthritis
3. Osteoarthritis
4. Joint sequelae of fractures and dislocations
5. Other inflammatory conditions of joints.
Periarticular or soft tissue injections:
1. Bursitis
2. Synovitis
3. Tendinitis
4. Taenosinovitis
5. Cystic tumors of tendon or aponeurosis
6. Epicondylitis
7. Scapulo-humeral periarthritis
8. Periarthritis of hip
9. Tarsalgias
10. Meta-tarsalgias
11. Dupuytren`s contracture
12. Peyronie`s disease.

Intra-lesional injections:
1. Tubal stenosis in gynaecology
2. Dermatological lesions
3. Keloids
4. Hypertrophic scars
5. Localized hypertrophies
6. Inflammatory lesions of lichen
7. Lichen simplex chronicus
8. Granuloma annulare
9. Alopecia areata
10. Necrobiosis lipoidica diabeticorum
11. Discoid lupus erythematosus
12. Psoriatic plaques
Intra-thecal or epidural injections:
1. Lumbago
2. Cervico-brachial neuralgia
3. Sciatica
4. Other painful radiculopathies
5. Multiple sclerosis
6. Tuberculous meningitis.
Interactions for Hydrocortisone
N/A
Typical Dosage for Hydrocortisone
Cream:
Apply 0.5% to 2.5% 1 to 4 times daily as required.
Ointment:
0.5% to 2.5% Apply 1 to 4 times as required.
Lotion:
0.5% to 2.5% Apply 1 to 4 times as required.
Intra-articular, Intra-dermal, Intra-pleural injection:
5 to 50mg depending up on the size of the joint and severity of the condition.

Schedule of Hydrocortisone
H
Storage Requirements for Hydrocortisone
Store at room temperature at a range of 15 to 300C. Protect from light and moisture. Keep out of reach of children.
Effects of Missed Dosage of Hydrocortisone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Hydrocortisone
Provide symptomatic treatment and supportive measures.

Lidocaine

About Lidocaine
Amide derivative , Antiarrhythmic(Class Ib) ,Local anesthetic.
Mechanism of Action of Lidocaine
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Pharmacokinets of Lidocaine
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Onset of Action for Lidocaine
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Duration of Action for Lidocaine
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Half Life of Lidocaine
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Side Effects of Lidocaine
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Contra-indications of Lidocaine
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Special Precautions while taking Lidocaine
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Lidocaine
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Interactions for Lidocaine
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Typical Dosage for Lidocaine
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Schedule of Lidocaine
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Storage Requirements for Lidocaine
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Effects of Missed Dosage of Lidocaine
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Effects of Overdose of Lidocaine
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Zinc oxide

About Zinc oxide
Zinc compound, A sunscreen,antipruritic.
Mechanism of Action of Zinc oxide
It works by providing a skin barrier and helps in healing and prevent skin irritation. It acts as a sunscreen which absorbs incident solar radiation in the UVA ranges and reduces its transmission to the skin.
Pharmacokinets of Zinc oxide
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Onset of Action for Zinc oxide
N/A
Duration of Action for Zinc oxide
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Half Life of Zinc oxide
N/A
Side Effects of Zinc oxide
1.Rash
2.Hives
3.Difficulty breathing
4.Tightness in the chest
5.Swelling of the mouth, face, lips, or tongue
6.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
7.Stop using zinc oxide rectal suppositories if you have rectal bleeding or continued pain.

Contra-indications of Zinc oxide
1.Hypersensitivity to Zinc oxide
2.Allergic to zinc, dimethicone, lanolin, cod liver oil, petroleum jelly, parabens, mineral oil, or wax.
Special Precautions while taking Zinc oxide
1.Allergic to Zinc preparations
2.Zinc oxide topical will not treat a bacterial or fungal infection
3.Keep the diaper area clean and dry to prevent worsening of skin rash. Change wet diapers as soon as possible. Allow the skin to dry thoroughly before putting on a fresh diaper
4.Avoid getting this medication in your mouth or eyes
5.Do not use zinc oxide topical on deep skin wounds or severe burns
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Zinc oxide
1.To prevent minor skin irritations such as burns, cuts, poison ivy, poison oak, poison sumac, and diaper rash.
2.As sunscreen
3.Zinc oxide topical (for the skin) is used to treat diaper rash, minor burns, severely chapped skin, or other minor skin irritations.
4.Zinc oxide rectal suppositories are used to treat itching, burning, irritation, and other rectal discomfort caused by hemorrhoids or painful bowel movements
Interactions for Zinc oxide
N/A
Typical Dosage for Zinc oxide
Apply the medicament to the affected part 2 times daily.
Schedule of Zinc oxide
N/A
Storage Requirements for Zinc oxide
Store at 15 - 30 degree C.Protect from heat,light and moisture.Keep out of the reach of children.
Effects of Missed Dosage of Zinc oxide
Apply the missed dose as soon as noticed.
Effects of Overdose of Zinc oxide
Give supportive measures and symptomatic treatment.

Home Delivery for Hydrocortisone + Lidocaine + Zinc Oxide in Your City

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Hydrocortisone + Lidocaine + Zinc Oxide is a generic medicine name and there are several brands available for it. Some of the brands for hydrocortisone + lidocaine + zinc oxide might be better known than hydrocortisone + lidocaine + zinc oxide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydrocortisone + lidocaine + zinc oxide in stock, you can ask for one of the branded alternatives for hydrocortisone + lidocaine + zinc oxide.