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- Pharmacology For Perindropil + Amlodipine
Perindropil + Amlodipine Pharmacology
Perindropil + AmlodipineAbout Perindropil + AmlodipineN/AMechanism of Action of Perindropil + AmlodipineN/APharmacokinets of Perindropil + AmlodipineN/AOnset of Action for Perindropil + AmlodipineN/ADuration of Action for Perindropil + AmlodipineN/AHalf Life of Perindropil + AmlodipineN/ASide Effects of Perindropil + AmlodipineN/AContra-indications of Perindropil + AmlodipineN/ASpecial Precautions while taking Perindropil + AmlodipineN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Perindropil + AmlodipineHypertensionInteractions for Perindropil + AmlodipineN/ATypical Dosage for Perindropil + AmlodipineN/ASchedule of Perindropil + AmlodipineN/AStorage Requirements for Perindropil + AmlodipineStore in a well closed container. Keep out of the reach of childrenEffects of Missed Dosage of Perindropil + AmlodipineN/AEffects of Overdose of Perindropil + AmlodipineN/AAbout N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/A
AmlodipineAbout AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
12.Aggravates myocardial ischaemia
Contra-indications of Amlodipine1.Heart failure
3.Hypersensitivity to the drug
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.
Home Delivery for Perindropil + Amlodipine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including perindropil + amlodipine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for perindropil + amlodipine and other medicines and health products. Home delivery services for perindropil + amlodipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take perindropil + amlodipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for perindropil + amlodipine before they complete the sale. You can get this information while placing the order for perindropil + amlodipine with the pharmacy.
Perindropil + Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for perindropil + amlodipine might be better known than perindropil + amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have perindropil + amlodipine in stock, you can ask for one of the branded alternatives for perindropil + amlodipine.