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- Pharmacology For Glycerine + Magnesium Sulphate
Glycerine + Magnesium Sulphate Pharmacology
Glycerine + Magnesium Sulphate
About Glycerine + Magnesium SulphateN/AMechanism of Action of Glycerine + Magnesium SulphateN/APharmacokinets of Glycerine + Magnesium SulphateN/AOnset of Action for Glycerine + Magnesium SulphateN/ADuration of Action for Glycerine + Magnesium SulphateN/AHalf Life of Glycerine + Magnesium SulphateN/ASide Effects of Glycerine + Magnesium SulphateN/AContra-indications of Glycerine + Magnesium SulphateN/ASpecial Precautions while taking Glycerine + Magnesium SulphateN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Glycerine + Magnesium SulphateMinor Skin infectionsInteractions for Glycerine + Magnesium SulphateN/ATypical Dosage for Glycerine + Magnesium SulphateApply to the affected area and cover with a clean dressingSchedule of Glycerine + Magnesium SulphateN/AStorage Requirements for Glycerine + Magnesium SulphateStore in a well closed container. Keep out of the reach of childrenEffects of Missed Dosage of Glycerine + Magnesium SulphateN/AEffects of Overdose of Glycerine + Magnesium SulphateN/AGlycerine
About GlycerineN/AMechanism of Action of GlycerineGlycerine is a sweet clear viscous liquid with dehydrating property. It produces a warm sensation and irritates mucous membranes. When used as a suppository and applied to anal canal it induces evacuation. Glycerine soothes the irritated skin so it is used as a component of cough mixtures. When a 50% solution of Glycerine in water is applied to dry and chapped skin it acts as an emollient. When used a 10% solution I.V. it reduces intraocular or intracranial pressure. When used as a diuretic it significantly increases the osmolality of plasma and tubular fluid. It is pharmacologically inert and freely filtered at glomerulus and undergoes limited reabsorption by renal tubule and acts as osmotic diuretic.Pharmacokinets of GlycerineAbsorption: Well absorbed orally.
Metabolism: Metabolized in the liver, kidney, and other tissues.
Excretion: Excreted through urine.
Onset of Action for GlycerineN/ADuration of Action for GlycerineN/AHalf Life of Glycerine30 to 45 minutes.Side Effects of GlycerineOral administration :
1.Nausea
2.Vomiting
3.Headache
4.Confusion
5.Disorientation
6.Dehydration
7.Amnesia in elderly people
Rectal administration :
1. Griping
2. Diarrhea
3. Nausea
4. Vomiting
5. Perianal irritation
6. Abdominal cramps
7. Weakness
8. Dizziness
9. Syncope
Ophthalmic administration :
1. Irritation
2. Pain
Contra-indications of GlycerineOral Glycerine is contraindicated in :-
1. Hypersensitivity to Glycerine
2. Severe dehydration
3. Anuria
4. Congestive heart failure
5. Pulmonary edema
6. Hypervolemia
Rectal administration is contraindicated in:-
1. Signs of appendicitis
2. Acute surgical abdomen
3. Fecal impaction
4. Intestinal obstruction
5. Undiagnosed abdominal pain
Special Precautions while taking Glycerine1. Confused mental states
2. Diabetes
3. Cardiac disease
4. Renal impairment
5. Hepatic impairment
6. Hemolytic anemia
7. While using oral glycerol drink plenty of fluid concomitantly
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationMay be usedIndications for Glycerine1. As an ingredient of cough mixtures
2. As osmotic diuretic
3. As Emollient
4. Constipation
4. To reduce intraocular or intracranial tension
5. Glaucoma
Interactions for GlycerineN/ATypical Dosage for GlycerineOral:
As osmotic diuretic: 1.5g/kg as oral solution.
Topical:
Emollient: Apply a 50% solution over dry and chapped skin
Orally or per Rectum:
For evacuation: 50 to 75% Glycerine per rectum or orally.
Adults and children > 6 years: Insert 1 suppository; high in the rectum and retain for 15 minutes. Alternatively, 5-15 ml can be used as an enema.
Children < 6 years: Insert 1 infant suppository 1-2 times daily as needed. Alternatively, 2-5 ml as an enema may be used.
Neonates: 0.5 ml/kg/dose as an enema.
I.V.:
To reduce intraocular or intracranial tension: 10% Glycerine intravenously.
Oral: 1 to 1.8g/kg orally. Additional doses may be administered at 5 hour intervals. If used prior to ocular surgery, dosing should begin 1-1.5 hours before the procedure
For use during ophthalmic examination:
Adults: Instill 1 or 2 drops of Ophthalmic dosage prior to examination of edematous cornea.
Schedule of GlycerineN/AStorage Requirements for GlycerineStore at room temperature at a range of 15 to 30 degree C in a well closed container. Protect from direct sunlight and moisture. Avoid metal containers and contact with strong oxidizing agents.Effects of Missed Dosage of GlycerineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GlycerineGive supportive measures and symptomatic treatment.MAGNESIUM SULPHATE
About MAGNESIUM SULPHATESaline Laxative, Osmotically actingMechanism of Action of MAGNESIUM SULPHATEOral: Magnesium sulfate increases peristaltic activity by causing osmotic retention of fluids, thus resulting in bowel evacuation. Parenteral: Magnesium sulfate decreases levels of acetylcholine in motor nerve terminals. It also acts on the myocardium by decreasing the rate of SA node impulse formation and prolonging the conduction timePharmacokinets of MAGNESIUM SULPHATEAbsorption: Absorbed after oral and IM administration
Distribution: Crosses the placenta and small amounts enter the breastmilk. Protein-binding: 25-30%
Excretion: Via urine (absorbed fraction); Via faeces (unabsorbed fraction)
Onset of Action for MAGNESIUM SULPHATEOral: 1 to 2hr, IM: 1 hr, IV: ImmediateDuration of Action for MAGNESIUM SULPHATEIM: 3 to 4 hr, IV: 30 minuteHalf Life of MAGNESIUM SULPHATEN/ASide Effects of MAGNESIUM SULPHATE1.Diarrhoea
2.Bradycardia
3.CNS depression
4.Hypocalcemia
5.Nausea
6.Vomiting
Contra-indications of MAGNESIUM SULPHATE1.Myocardial Infarction
2.Heart Block
3.Renal Impairment
Special Precautions while taking MAGNESIUM SULPHATE1.Renal impairment
2.Myasthaenia gravis
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for MAGNESIUM SULPHATE1.Seizures in pregnancy
2.Hypomagnesaemia
3.Heart attack
4.Asthma
5.Constipation
Interactions for MAGNESIUM SULPHATEOral: Decreases absorption of tetracyclines and biphosphonates
Additive neuromuscular blocking effects with aminoglycosides, digitalis glycosides
Additive effects with nifedipine and CNS depressants
Typical Dosage for MAGNESIUM SULPHATE1.5 gm 6 hourly IV or IM. Dosage is adjusted according to individual requirements and the response to treatmentSchedule of MAGNESIUM SULPHATEN/AStorage Requirements for MAGNESIUM SULPHATEStore in a well closed container, below 40 degree celcius. Protect from sunlight and moisture. Keep out of the reach of childrenEffects of Missed Dosage of MAGNESIUM SULPHATEN/AEffects of Overdose of MAGNESIUM SULPHATEN/AHome Delivery for Glycerine + Magnesium Sulphate in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glycerine + magnesium sulphate and other medicines and health products. Home delivery services for glycerine + magnesium sulphate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Glycerine + Magnesium Sulphate is a generic medicine name and there are several brands available for it. Some of the brands for glycerine + magnesium sulphate might be better known than glycerine + magnesium sulphate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glycerine + magnesium sulphate in stock, you can ask for one of the branded alternatives for glycerine + magnesium sulphate.
