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- Pharmacology For Quinapril hydrochloride + Hydrochlorothiazide
Quinapril hydrochloride + Hydrochlorothiazide Pharmacology
Quinapril hydrochloride + HydrochlorothiazideAbout Quinapril hydrochloride + HydrochlorothiazideN/AMechanism of Action of Quinapril hydrochloride + HydrochlorothiazideN/APharmacokinets of Quinapril hydrochloride + HydrochlorothiazideN/AOnset of Action for Quinapril hydrochloride + HydrochlorothiazideN/ADuration of Action for Quinapril hydrochloride + HydrochlorothiazideN/AHalf Life of Quinapril hydrochloride + HydrochlorothiazideN/ASide Effects of Quinapril hydrochloride + Hydrochlorothiazide1.Bradycardia
Contra-indications of Quinapril hydrochloride + HydrochlorothiazideN/ASpecial Precautions while taking Quinapril hydrochloride + HydrochlorothiazideN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Quinapril hydrochloride + HydrochlorothiazideHypertensionInteractions for Quinapril hydrochloride + Hydrochlorothiazide1.ACTH, Corticosteroid: Electrolyte depletion may be intensified, especially hypokalemia
2.Anticoagulants: Anticoagulant effect may be decreased
3.Antidiabetic agenst: Dosage adjustment may be necessary because of possible hydrochlorothiazide-induced elevation in blood glucose levels
4.Lithium: Plasma levels of lithium may be elevated, increasing the risk of toxicity
Typical Dosage for Quinapril hydrochloride + HydrochlorothiazideAs directed by the physician.Schedule of Quinapril hydrochloride + HydrochlorothiazideN/AStorage Requirements for Quinapril hydrochloride + HydrochlorothiazideStore in a tightly closed container at room temperature. Keep out of the reach of children.
Effects of Missed Dosage of Quinapril hydrochloride + HydrochlorothiazideN/AEffects of Overdose of Quinapril hydrochloride + HydrochlorothiazideN/A
Quinapril HydrochlorideAbout Quinapril HydrochlorideACE Inhibitors, AntihypertensivesMechanism of Action of Quinapril HydrochlorideQuinapril is a competitive inhibitor of angiotensin-converting enzyme (ACE). It prevents conversion of angiotensin I to angiotensin II resulting in lower levels of angiotensin II which causes an increase in plasma renin activity and a reduction in aldosterone secretion.Pharmacokinets of Quinapril HydrochlorideAbsorption: Absorbed after oral administration
Distribution: 97% bound to plasma proteins
Metabolism: Metabolised in the liver
Excretion: Excreted in the urine and faeces
Onset of Action for Quinapril HydrochlorideI hr after oral administrationDuration of Action for Quinapril HydrochlorideAbout 24 hrsHalf Life of Quinapril Hydrochloride2 hrsSide Effects of Quinapril Hydrochloride1.Dizziness
Contra-indications of Quinapril Hydrochloride1.Aortic stenosis or outflow tract obstruction
3.Hypersensitivity to the component
Special Precautions while taking Quinapril Hydrochloride1.Peripheral vascular diseases
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Quinapril Hydrochloride1.Hypertension
Interactions for Quinapril Hydrochloride1.Additive hyperkalaemic effects with potassium-sparing diuretics, potassium supplements, other drugs that can cause hyperkalaemia
2.Increased risk of renal impairment and reduced antihypertensive effect when used with NSAIDs
3.Excessive hypotension with diuretics, other antihypertensives, alcohol
Typical Dosage for Quinapril HydrochlorideHypertension
Adult: Initially, 10 mg once daily. Maintenance: 20-40 mg daily as a single dose or in 2 divided doses.
Elderly: Initially, 2.5 mg daily
Adult: Initially, 2.5 mg daily. Maintenance: 10-20 mg daily as a single dose or in 2 divided doses. Max dose: 40 mg daily.Schedule of Quinapril HydrochlorideN/AStorage Requirements for Quinapril HydrochlorideStore below 30 degree celcius in a well closed container. Keep out of the reach of children.Effects of Missed Dosage of Quinapril HydrochlorideN/AEffects of Overdose of Quinapril HydrochlorideN/A
HydrochlorothiazideAbout HydrochlorothiazideThiazide derivatibve, Diuretic.Mechanism of Action of HydrochlorothiazideIt is thiazide diuretic which exerts its action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It has additional carbonic anhydrase inhibitory actions in proximal tubules. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion. It also has minor carbonic anhydrase inhibitory action. It also causes direct arteriolar vasodilatation and decreases total peripheral resistance. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Vertigo: Diuretics are used in vertigo in assumption that vertigo is due to endolymphatic hydrops. They reduce labyrinthine fluid pressure
Pharmacokinets of HydrochlorothiazideAbsorption: It is absorbed after oral administration.
Metabolism: It is not metabolized in the body.
Excretion: Excreted unchanged in urine.
Onset of Action for Hydrochlorothiazide1 to 3 hoursDuration of Action for Hydrochlorothiazide12 to 16 hoursHalf Life of Hydrochlorothiazide5 to 15 hoursSide Effects of Hydrochlorothiazide1. Dizziness
2. Blurred vision
4. Tingling fingers
5. Dry mouth
14. Elevated levels of glucose, calcium and lipids
15. Gastro intestinal disturbances
17. Electrolyte imbalance
24. Muscle cramps
26. Blood dyscrasias
Contra-indications of Hydrochlorothiazide1. Hyper uricaemia
2. Hyper calcaemia
3. Renal impairment
4. Hepatic impairment
6. Hypersensitivity to the drug
7. Hyper sensitivity to sulfonamides
8. Fluid and electrolyte imbalance
Special Precautions while taking Hydrochlorothiazide1. Gout
2. Diabetes mellitus
3. Renal impairment
4. Hepatic impairment
5. Monitor and correct Fluid and electrolyte imbalance
6. Hyper parathyroidism
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationMay be usedIndications for Hydrochlorothiazide1. Hypertension
2. Oedema associated with heart failure
3. Oedema due to renal and hepatic diseases
4. Diabetes insipidus
5. Idiopathic hypercalciurea.
Interactions for HydrochlorothiazideCholestyramine & Colestipol: decrease absorption of hydrochlorothiazide.
Diazoxide: Additive action - may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretics induced hypokalaemia may precipitate digitalis toxicity.
Lithium: Hydrochlorothiazide potentiates therapeutic and toxic effects by increasing its renal excretion.
Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss.
Non-depolarizing muscle relaxants: Diuretics induced hypokalaemia enhances efficacy.
Sulfonylureas: Efficacy decreased due to hydrochlorothiazide induced glucose intolerance.
Propantheline: Bioavailability of hydrochlorothiazide increased.
Metoclopramide: Bioavailability of hydrochlorothiazide decreased.
NSAIDs: Natriuretic effect of hydrochlorothiazide decreased.
Typical Dosage for HydrochlorothiazideAdults:
Hypertension: 25mg once daily or in divided doses. Increased to 50mg if required; depending up on the patient`s response.
Children: 1mg/kg single daily dose.
Starts with 25 to 50mg. Increased the dose until desired response is obtained.
Maximum dose: 200mg/day
Maintenance dosage: 25 to 100mg daily or on alternate days.
Children: 1mg/kg single daily dose or 1 to 3mg/kg/day in two divided doses
Schedule of HydrochlorothiazideGStorage Requirements for HydrochlorothiazideStore at room temperature in a well closed container and protected from light.Effects of Missed Dosage of HydrochlorothiazideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of HydrochlorothiazideTreatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.
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