Beclomethasone Dipropionate + Salbutamol Pharmacology

Beclomethasone Dipropionate + Salbutamol

About Beclomethasone Dipropionate + Salbutamol
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Mechanism of Action of Beclomethasone Dipropionate + Salbutamol
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Pharmacokinets of Beclomethasone Dipropionate + Salbutamol
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Onset of Action for Beclomethasone Dipropionate + Salbutamol
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Duration of Action for Beclomethasone Dipropionate + Salbutamol
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Half Life of Beclomethasone Dipropionate + Salbutamol
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Side Effects of Beclomethasone Dipropionate + Salbutamol
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Contra-indications of Beclomethasone Dipropionate + Salbutamol
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Special Precautions while taking Beclomethasone Dipropionate + Salbutamol
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Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Beclomethasone Dipropionate + Salbutamol
Asthma
Interactions for Beclomethasone Dipropionate + Salbutamol
N/A
Typical Dosage for Beclomethasone Dipropionate + Salbutamol
Adults: Two inhalations, three or four times daily, titrated to the lowest effective dose
Children: One or two inhalations, two, three or four times daily
Schedule of Beclomethasone Dipropionate + Salbutamol
N/A
Storage Requirements for Beclomethasone Dipropionate + Salbutamol
Store at room temperature. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Beclomethasone Dipropionate + Salbutamol
N/A
Effects of Overdose of Beclomethasone Dipropionate + Salbutamol
N/A

Beclomethasone dipropionate

About Beclomethasone dipropionate
Potent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.
Mechanism of Action of Beclomethasone dipropionate
Mechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.


Pharmacokinets of Beclomethasone dipropionate
Absorption: It enters in to the systemic circulation after topical administration.
Onset of Action for Beclomethasone dipropionate
N/A
Duration of Action for Beclomethasone dipropionate
N/A
Half Life of Beclomethasone dipropionate
N/A
Side Effects of Beclomethasone dipropionate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate
1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Beclomethasone dipropionate
1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionate
There are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionate
Topical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected area
Schedule of Beclomethasone dipropionate
H
Storage Requirements for Beclomethasone dipropionate
Store below 25 degree C in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Beclomethasone dipropionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Beclomethasone dipropionate
Give supportive measures and symptomatic treatment.

Salbutamol

About Salbutamol
Beta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma), uterine relaxant.
Mechanism of Action of Salbutamol
Salbutamol is a short acting ?2 receptor agonist. It selectively stimulates ?2 receptors present in airway, Uterus, and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators. Salbutamol is effective in the management of preterm labour.
Pharmacokinets of Salbutamol
Absorption: It is well absorbed after oral administration.
Distribution: Salbutamol does not cross the blood brain barrier.
Metabolism: It is metabolised to inactive metabolites in the liver
Excretion: Salbutamol is excreted primarily in the urine and small amount in the faeces.
Onset of Action for Salbutamol
15 - 30 minutes
Duration of Action for Salbutamol
6 - 12 hours
Half Life of Salbutamol
4 hours
Side Effects of Salbutamol
1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Hypokalaemia (high dose)

Contra-indications of Salbutamol
1.Hypersensitivity to Salbutamol and other sympathomimetic amines.
Special Precautions while taking Salbutamol
1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution
Below 6 years: contraindicated
Indications for Salbutamol
1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for Salbutamol
Beclomethasone, Theophylline: Enhances respiratory function.
Beta-blockers: Inhibit bronchodilator effect.
Diuretics and Xanthines: Increased risk of hypokalemia.
Digitalis: Increased risk of digitalis toxicity when salbutamol is given in hilgh doses due to hypokalaemia.
Typical Dosage for Salbutamol
Adult:
Oral:
Immediate release tablet: 2 - 4 mg every 6 - 8 hours daily, maximum dose 32mg / day
Sustained release tablets: 8 mg / day in 2 divided doses and if sufficient response does not obtained then dose can be gradually increased to 16mg / day in 2 divided doses
Children: 6 - 14 years
Syrup: 6 - 8mg / day in 3 - 4 divided doses and if needed dose can be increased maximum up to 24mg / day
Uterine Relaxant: (I.V) 4 to 32 mcg/minutes

Schedule of Salbutamol
H
Storage Requirements for Salbutamol
Store at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Salbutamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Salbutamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.

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Beclomethasone Dipropionate + Salbutamol is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate + salbutamol might be better known than beclomethasone dipropionate + salbutamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate + salbutamol in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate + salbutamol.