Oxazepam Pharmacology

Oxazepam

About Oxazepam
Anxiolytic,benzodiazepines
Mechanism of Action of Oxazepam
Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a cooperative mechanism of action. GABA receptors are ionotropic chloride-linked channel receptors that produce inhibitory postsynaptic potentials. Benzodiazepine binding increases chloride conductance in the presence of GABA by increasing the frequency at which the channel opens.
Pharmacokinets of Oxazepam
Absorption: Well absorbed from the GI tract
Distribution: Crosses the placenta and detected in breast milk. Protein-binding: 85-97%.
Metabolism: Hepatic; extensively metabolised to inactive glucuronide.
Excretion: Via urine as unchanged drug and inactive metabolites.
Onset of Action for Oxazepam
N/A
Duration of Action for Oxazepam
N/A
Half Life of Oxazepam
3-21 hr.
Side Effects of Oxazepam
1.Dizziness
2.Drowsiness
3.Headache
4.Memory impairment
5.Paradoxical excitement
6.Retrograde amnesia
7.Rapid decrease in dose or abrupt withdrawal from oxazepam causes
8.Abdominal and muscle cramps
9.Convulsions
10.Depression
11.Inability to fall asleep or stay asleep
12.Sweating
13.Tremors
14.Vomiting.
Contra-indications of Oxazepam
1.Psychoses
2.Myasthenia gravis
3.Chronic obstructive pulmonary disease and limited pulmonary reserve
4.Severe hepatic disease
Special Precautions while taking Oxazepam
1.Cross-sensitivity with other benzodiazepines may occur.
2.Hepatic and renal impairment.
3.Respiratory disease.
4.Debilitated patients, elderly.
5.Withdraw gradually.
6.Porphyria.
7.History of drug abuse or acute alcoholism.
8.May impair ability to drive or operate machinery.
9.CV or cerebrovascular disease, intolerance to transient decreases in BP.
10.Depression or if suicidal risk is present.
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Oxazepam
For the treatment of anxiety disorders and alcohol withdrawal.
Interactions for Oxazepam
1.Reduced sedative effects with theophylline and other CNS stimulants.
2.Increased incidence of headache with zidovudine.
3.May reduce effects of levodopa.
4.Potentially Fatal: Additive CNS depression with alcohol and other CNS depressants.
Typical Dosage for Oxazepam
N/A
Schedule of Oxazepam
N/A
Storage Requirements for Oxazepam
: Store at 15-30?C (59-86?F).
Effects of Missed Dosage of Oxazepam
N/A
Effects of Overdose of Oxazepam
N/A

Home Delivery for Oxazepam in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxazepam.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxazepam and other medicines and health products. Home delivery services for oxazepam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxazepam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxazepam before they complete the sale. You can get this information while placing the order for oxazepam with the pharmacy.

Oxazepam is a generic medicine name and there are several brands available for it. Some of the brands for oxazepam might be better known than oxazepam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxazepam in stock, you can ask for one of the branded alternatives for oxazepam.