Albendazole+ Ivermectin Pharmacology

Albendazole+ Ivermectin

About Albendazole+ Ivermectin
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Mechanism of Action of Albendazole+ Ivermectin
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Pharmacokinets of Albendazole+ Ivermectin
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Onset of Action for Albendazole+ Ivermectin
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Duration of Action for Albendazole+ Ivermectin
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Half Life of Albendazole+ Ivermectin
N/A
Side Effects of Albendazole+ Ivermectin
1.Diarrhoea
2.Nausea
3.Vomiting
4.Dizziness
5.Pruritus
6.Urticaria
7.Rash
8.Arthralgia
9.Fever
10.Myalgia
11.Asthenia
12.Postural hypotension,
13.Tachycardia
14.Oedema
15.Lymphadenopathy
16.Sore throat
17.Cough
18.Headache, somnolence
19.Transient eosinophilia
20.Raised liver enzyme values.
Contra-indications of Albendazole+ Ivermectin
Hypersensitivity
Special Precautions while taking Albendazole+ Ivermectin
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
<5 yrs or <15 kg body weight,contra indicated
Indications for Albendazole+ Ivermectin
Nematode infestations
Interactions for Albendazole+ Ivermectin
1.Cimetidine increases albendazole metabolism.
2.Serum levels are increased if taken with dexamethasone and praziquantel agent.
Typical Dosage for Albendazole+ Ivermectin
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Schedule of Albendazole+ Ivermectin
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Storage Requirements for Albendazole+ Ivermectin
N/A
Effects of Missed Dosage of Albendazole+ Ivermectin
N/A
Effects of Overdose of Albendazole+ Ivermectin
N/A

Albendazole

About Albendazole
Benzimidazole derivative, Antihelmintic.
Mechanism of Action of Albendazole
Albendazole is used as a broad spectrum anthelminthic which acts by blocking glucose uptake in the parasite and depletion of its glycogen stores. It causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminthes and larvae. Intracellular microtubules in the cells of the worm are gradually lost. The drug binds to beta tubulin of susceptible worms with high affinity and inhibits its polymerization. Single dose treatment is effective against Ascaris, Hook worm, and Enterobius. It is superior to Mebendazole for treatment of Hydatid worm, and strongyloidosis. It is also used in the treatment of tape worms, Filariasis, and Trichuriasis.
Pharmacokinets of Albendazole
Absorption: Poorly absorbed after oral administration and undergoes first pass metabolism. Distribution: Albendazole sulfoxide is widely distributed in the body, Metabolism: Metabolized mainly by sulfoxidation. Excretion: Excreted through urine.
Onset of Action for Albendazole
N/A
Duration of Action for Albendazole
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Half Life of Albendazole
8 to 12 hours.
Side Effects of Albendazole
1.Epigastric distress
2.Nausea
3.Vomiting
4.Altered liver enzyme levels.
Prolonged use as in Neurocysticercosis and Hydatid worm infestation causes side effects such as:
1.Headache
2.Dizziness
3.Alopecia
4.Jaundice
5.Neutropenia
Contra-indications of Albendazole
1 Hypersensitivity to the drug.
Special Precautions while taking Albendazole
1.Hepatic impairment
2.Renal impairment
3.Women of childbearing age should be cautioned against becoming pregnant while on Albendazole or within 1 month of completing treatment, 4.Perform liver function tests and blood counts during prolonged therapy.
Pregnancy Related Information
Contraindicated.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
May be used.
NEONATES:Contraindicated
Indications for Albendazole
1.Hook worm infestation
2.Pin worm infestation
3.Round worm infestation
4.Neurocysticercosis
5.Strongyloidiasis
6.Taeniasis
7.H. nana infestation
8.Giardiasis.
9.Hydatid worm infestation
Interactions for Albendazole
Praziquantel: Efficacy of albendazole enhanced .
Cimetidine: Albendazole sulphoxide concentration in bile and cystic fluid increase 2 fold in hydatid cyst disease.
Typical Dosage for Albendazole
Oral:
Adults and children after 2 years:
Hook worm, Pin worm, and Round worm:
400mg as a single dose. Repetition after 3 weeks increases efficiency.
Neurocysticercosis:
400mg tablet twice daily with meals; for 8 days to one month. Dose should not exceed 15mg/kg/day. Administer anticonvulsants and steroids along with the therapy.
Hydatid worm:
400mg twice daily for four weeks with a drug free interval of 14 days. Repeat for 3 cycles. Dose should not exceed 15mg/kg/day.
Strongyloidiasis, Taeniasis, H. nana infections:
400mg single dose for 3 consecutive days. Repeat after 3 weeks if required.
Giardiasis:
400mg once daily for 3 to 5 days.
Children (age 1 to 2 years): 200mg as a single dose.
Schedule of Albendazole
H
Storage Requirements for Albendazole
Store in a well closed container at a temperature range of 15 to 300C. Protect from light, heat, and moisture.
Effects of Missed Dosage of Albendazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Albendazole
Provide symptomatic treatment and supportive measures.

Ivermectin

About Ivermectin
An aminoglycoside antibiotic, Antibiotic.
Mechanism of Action of Ivermectin
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Pharmacokinets of Ivermectin
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Onset of Action for Ivermectin
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Duration of Action for Ivermectin
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Half Life of Ivermectin
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Side Effects of Ivermectin
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Contra-indications of Ivermectin
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Special Precautions while taking Ivermectin
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Ivermectin
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Interactions for Ivermectin
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Typical Dosage for Ivermectin
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Schedule of Ivermectin
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Storage Requirements for Ivermectin
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Effects of Missed Dosage of Ivermectin
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Effects of Overdose of Ivermectin
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Home Delivery for Albendazole+ Ivermectin in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for albendazole+ ivermectin and other medicines and health products. Home delivery services for albendazole+ ivermectin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take albendazole+ ivermectin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for albendazole+ ivermectin before they complete the sale. You can get this information while placing the order for albendazole+ ivermectin with the pharmacy.

Albendazole+ Ivermectin is a generic medicine name and there are several brands available for it. Some of the brands for albendazole+ ivermectin might be better known than albendazole+ ivermectin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have albendazole+ ivermectin in stock, you can ask for one of the branded alternatives for albendazole+ ivermectin.