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- Pharmacology For Albendazole+ Ivermectin
Albendazole+ Ivermectin Pharmacology
Albendazole+ IvermectinAbout Albendazole+ IvermectinN/AMechanism of Action of Albendazole+ IvermectinN/APharmacokinets of Albendazole+ IvermectinN/AOnset of Action for Albendazole+ IvermectinN/ADuration of Action for Albendazole+ IvermectinN/AHalf Life of Albendazole+ IvermectinN/ASide Effects of Albendazole+ Ivermectin1.Diarrhoea
20.Raised liver enzyme values.
Contra-indications of Albendazole+ IvermectinHypersensitivitySpecial Precautions while taking Albendazole+ IvermectinN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related Information<5 yrs or <15 kg body weight,contra indicatedIndications for Albendazole+ IvermectinNematode infestationsInteractions for Albendazole+ Ivermectin1.Cimetidine increases albendazole metabolism.
2.Serum levels are increased if taken with dexamethasone and praziquantel agent.
Typical Dosage for Albendazole+ IvermectinN/ASchedule of Albendazole+ IvermectinN/AStorage Requirements for Albendazole+ IvermectinN/AEffects of Missed Dosage of Albendazole+ IvermectinN/AEffects of Overdose of Albendazole+ IvermectinN/A
AlbendazoleAbout AlbendazoleBenzimidazole derivative, Antihelmintic.Mechanism of Action of AlbendazoleAlbendazole is used as a broad spectrum anthelminthic which acts by blocking glucose uptake in the parasite and depletion of its glycogen stores. It causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminthes and larvae. Intracellular microtubules in the cells of the worm are gradually lost. The drug binds to beta tubulin of susceptible worms with high affinity and inhibits its polymerization. Single dose treatment is effective against Ascaris, Hook worm, and Enterobius. It is superior to Mebendazole for treatment of Hydatid worm, and strongyloidosis. It is also used in the treatment of tape worms, Filariasis, and Trichuriasis.Pharmacokinets of AlbendazoleAbsorption: Poorly absorbed after oral administration and undergoes first pass metabolism. Distribution: Albendazole sulfoxide is widely distributed in the body, Metabolism: Metabolized mainly by sulfoxidation. Excretion: Excreted through urine.Onset of Action for AlbendazoleN/ADuration of Action for AlbendazoleN/AHalf Life of Albendazole8 to 12 hours.Side Effects of Albendazole1.Epigastric distress
4.Altered liver enzyme levels.
Prolonged use as in Neurocysticercosis and Hydatid worm infestation causes side effects such as:
Contra-indications of Albendazole1 Hypersensitivity to the drug.Special Precautions while taking Albendazole1.Hepatic impairment
3.Women of childbearing age should be cautioned against becoming pregnant while on Albendazole or within 1 month of completing treatment, 4.Perform liver function tests and blood counts during prolonged therapy.Pregnancy Related InformationContraindicated.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationMay be used.
NEONATES:ContraindicatedIndications for Albendazole1.Hook worm infestation
2.Pin worm infestation
3.Round worm infestation
7.H. nana infestation
9.Hydatid worm infestation
Interactions for AlbendazolePraziquantel: Efficacy of albendazole enhanced .
Cimetidine: Albendazole sulphoxide concentration in bile and cystic fluid increase 2 fold in hydatid cyst disease.Typical Dosage for AlbendazoleOral:
Adults and children after 2 years:
Hook worm, Pin worm, and Round worm:
400mg as a single dose. Repetition after 3 weeks increases efficiency.
400mg tablet twice daily with meals; for 8 days to one month. Dose should not exceed 15mg/kg/day. Administer anticonvulsants and steroids along with the therapy.
400mg twice daily for four weeks with a drug free interval of 14 days. Repeat for 3 cycles. Dose should not exceed 15mg/kg/day.
Strongyloidiasis, Taeniasis, H. nana infections:
400mg single dose for 3 consecutive days. Repeat after 3 weeks if required.
400mg once daily for 3 to 5 days.
Children (age 1 to 2 years): 200mg as a single dose.
Schedule of AlbendazoleHStorage Requirements for AlbendazoleStore in a well closed container at a temperature range of 15 to 300C. Protect from light, heat, and moisture.Effects of Missed Dosage of AlbendazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AlbendazoleProvide symptomatic treatment and supportive measures.
IvermectinAbout IvermectinAn aminoglycoside antibiotic, Antibiotic.Mechanism of Action of IvermectinN/APharmacokinets of IvermectinN/AOnset of Action for IvermectinN/ADuration of Action for IvermectinN/AHalf Life of IvermectinN/ASide Effects of IvermectinN/AContra-indications of IvermectinN/ASpecial Precautions while taking IvermectinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for IvermectinN/AInteractions for IvermectinN/ATypical Dosage for IvermectinN/ASchedule of IvermectinN/AStorage Requirements for IvermectinN/AEffects of Missed Dosage of IvermectinN/AEffects of Overdose of IvermectinN/A
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Albendazole+ Ivermectin is a generic medicine name and there are several brands available for it. Some of the brands for albendazole+ ivermectin might be better known than albendazole+ ivermectin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have albendazole+ ivermectin in stock, you can ask for one of the branded alternatives for albendazole+ ivermectin.