Insulin Glulisine Pharmacology

Insulin Glulisine

About Insulin Glulisine
Short acting insulin preparations.
Mechanism of Action of Insulin Glulisine
Insulin glulisine is a rapid acting human insulin analog produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12). Insulin glulisine and insulin human are equipotent on a unit-for-unit basis. Insulin glulisine has a more rapid onset and shorter duration of action compared with insulin human after subcutaneous admin.

Pharmacokinets of Insulin Glulisine
Absorption: Absolute bioavailability after subcutaneous admin: 70%.

Distribution: Protein binding: Low.
Onset of Action for Insulin Glulisine
Duration of Action for Insulin Glulisine
Half Life of Insulin Glulisine
42 minutes
Side Effects of Insulin Glulisine
3.Local and systemic hypersensitivity reactions.
Contra-indications of Insulin Glulisine
Special Precautions while taking Insulin Glulisine
1.Renal or hepatic impairment
2.Regular monitoring of blood glucose and HbA1c.
3.Rotate Inj sites to reduce lipodystrophy
Pregnancy Related Information
Use with caution
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Insulin Glulisine
Diabetes mellitus Type 1 and 2
Interactions for Insulin Glulisine
1.Possible absence of hypoglycaemic warning symptoms with ?-blockers.
2.Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotics (e.g. olanzapine and clozapine).
3.Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics.
4.Decreased insulin resistance with octreotide and lanreotide.
5.Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.
Typical Dosage for Insulin Glulisine
As directed by physician
Schedule of Insulin Glulisine
Storage Requirements for Insulin Glulisine
Subcutaneous: Unopened vial: Store in a refrigerator (2-8?C). Protect from light. Do not freeze. Once opened, it may be stored for a max of 4 wk <25?C.
Effects of Missed Dosage of Insulin Glulisine
Effects of Overdose of Insulin Glulisine

Home Delivery for Insulin Glulisine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including insulin glulisine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for insulin glulisine and other medicines and health products. Home delivery services for insulin glulisine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take insulin glulisine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for insulin glulisine before they complete the sale. You can get this information while placing the order for insulin glulisine with the pharmacy.

Insulin Glulisine is a generic medicine name and there are several brands available for it. Some of the brands for insulin glulisine might be better known than insulin glulisine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have insulin glulisine in stock, you can ask for one of the branded alternatives for insulin glulisine.