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- Pharmacology For Latanoprost + Benzalkonium Chloride
Latanoprost + Benzalkonium Chloride Pharmacology
Latanoprost + Benzalkonium ChlorideAbout Latanoprost + Benzalkonium ChlorideProstaglantin analoguesMechanism of Action of Latanoprost + Benzalkonium ChlorideLatanoprost is a prostaglandin F2a analogue. Specifically, Latanoprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow. Elevated IOP represents a major risk factor for glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss.Pharmacokinets of Latanoprost + Benzalkonium ChlorideAbsorption :Latanoprost is well absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form. Peak concentration is reached 2 hrs after topical administration.
Primarily hepatic (none except hydrolysis in the eye). Latanoprost is an isopropyl ester prodrug. It is hydrolyzed by esterases in the cornea to latanoprost acid, which is biologically active. The portion of the latanoprost acid that reaches the systemic circulation is metabolized primarily by the liver to 1,2-dinor and 1,2,3,4-tetranor metabolites by fatty acid beta-oxidation.
Onset of Action for Latanoprost + Benzalkonium ChlorideN/ADuration of Action for Latanoprost + Benzalkonium ChlorideN/AHalf Life of Latanoprost + Benzalkonium Chloride17 minutesSide Effects of Latanoprost + Benzalkonium Chloride1.Eyelash changes (increased length, thickness, pigmentation, and number of
2.Eyelid skin darkening
3.Intraocular inflammation (iritis/uveitis)
7.Cystoid macular edema
Contra-indications of Latanoprost + Benzalkonium ChlorideHypersensitivitySpecial Precautions while taking Latanoprost + Benzalkonium ChlorideN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Latanoprost + Benzalkonium ChlorideLatanoprost:for the reduction of elevated intraocular pressure in patients with open angle glaucoma and ocular hypertension.
Interactions for Latanoprost + Benzalkonium ChlorideN/ATypical Dosage for Latanoprost + Benzalkonium ChlorideN/ASchedule of Latanoprost + Benzalkonium ChlorideN/AStorage Requirements for Latanoprost + Benzalkonium ChlorideStore at temperature between 20 to 80 C. Protect from light., Once opened the vial
may be stored at room temperature.
Effects of Missed Dosage of Latanoprost + Benzalkonium ChlorideN/AEffects of Overdose of Latanoprost + Benzalkonium ChlorideN/A
LatanoprostAbout LatanoprostA prostaglandin analogue, Antiglaucoma.Mechanism of Action of LatanoprostLatanoprost is a prostaglandin F2-alpha analogue and it is a prostanoid selective FP receptor agonist which reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor mainly through increasing uveoscleral outflow.
Chemically Latanoprost is an isopropyl ester prodrug and after hydrolyses it forms active acid form.
Pharmacokinets of LatanoprostAbsorption: Latanoprost is absorbed through cornea after ocular administrationOnset of Action for Latanoprost2 - 4 hourDuration of Action for LatanoprostN/AHalf Life of LatanoprostN/ASide Effects of Latanoprost1.Irritation
4.Increased sensitivity of the eyes to light
6.Increased flow of tears
7.Changes in eye, eyelash, or eyelid color
8.Redness of eyes
11.Punctate epithelial keratopathy
Contra-indications of Latanoprost1.Hypersensitivity to LatanoprostSpecial Precautions while taking Latanoprost1.Avoid use of medicament if any irritation occurs
6.Closed angle glaucoma
7.Avoid contact lens
9.Hepatic impairmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
Indications for Latanoprost1.Open angle glaucoma
Interactions for LatanoprostN/ATypical Dosage for LatanoprostLatanoprost 0.005 % eye drop is used.
Instill 1 drop in the evening to the affected eye.
Schedule of LatanoprostN/AStorage Requirements for LatanoprostStore in a cool dry place in a tightly closed container. Protect fro heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.Effects of Missed Dosage of LatanoprostInstill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of LatanoprostA topical ocular overdose of an ophthalmic product containing Latanoprost may be flushed from the eye with warm tap water.
Benzalkonium ChlorideAbout Benzalkonium ChlorideA nitrogenous cationic surfactant, Quaternary ammonium compound, Antiseptic,Disinfectant, A vaginal contraceptive spermicidal agent.Mechanism of Action of Benzalkonium ChlorideThe mechanism of bactericidal/microbicidal action is due to disruption of intermolecular interactions. This cause dissociation of cellular membrane bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. It also inactivates the enzyme produced by different microorganisms. It also has spermicidal action. They work by damaging and killing sperm in the vagina. Therefore, the sperm are not able to travel from the vagina into the uterus and fallopian tubes, where fertilization usually takes place.Pharmacokinets of Benzalkonium ChlorideN/AOnset of Action for Benzalkonium ChlorideN/ADuration of Action for Benzalkonium ChlorideN/AHalf Life of Benzalkonium ChlorideN/ASide Effects of Benzalkonium Chloride1. Chills
6. Muscle aches
7. Sunburn-like skin rash
8. Cloudy or bloody urine
9. Increased frequency of urination
10. Pain in the bladder or lower abdomen
11. Pain on urination; thick
12. White or curd-like vaginal discharge-with use of cervical caps or diaphragms
13. Vaginal dryness
Contra-indications of Benzalkonium Chloride1. Hypersensitivity to the drug
2. Allergies, irritations, or infections of the genitals
3. Recent abortion
4. Sores on the genitals (sex organs)
5. Irritation of the vagina
Special Precautions while taking Benzalkonium ChlorideDiscontinue use if you have abnormal discharge or vaginal burning or itching.Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Benzalkonium Chloride1. Antisepsis of skin, mucous membranes, and wounds.
2. Preoperative preparation of the skin, surgeons` hand and arm soaks
3. Treatment of wounds
4. Preservation of ophthalmic solutions
5. Irrigations of the eye, body cavities, bladder, urethra
6. Vaginal douching.
Interactions for Benzalkonium ChlorideN/ATypical Dosage for Benzalkonium ChlorideVaginal suppositories dosage form (preventing pregnancy):
Adults and teenagers-
For use alone: One suppository inserted into the vagina at least ten minutes but not longer than four hours before each time you have sexual intercourse.
With a diaphragm: After the diaphragm with spermicide has been placed into the vagina, insert one suppository at least ten minutes, but not longer than four hours, before each time you have sexual intercourse. Also, insert another suppository before sexual intercourse if six hours have passed since you inserted the diaphragm
Schedule of Benzalkonium ChlorideN/AStorage Requirements for Benzalkonium ChlorideStore at controlled room temperature, away from light and excessive heat. Keep out of reach of children.Effects of Missed Dosage of Benzalkonium ChlorideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Benzalkonium ChlorideN/A
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Latanoprost + Benzalkonium Chloride is a generic medicine name and there are several brands available for it. Some of the brands for latanoprost + benzalkonium chloride might be better known than latanoprost + benzalkonium chloride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have latanoprost + benzalkonium chloride in stock, you can ask for one of the branded alternatives for latanoprost + benzalkonium chloride.