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- Pharmacology For Mecobalamin + Adenosylcobalamin
Mecobalamin + Adenosylcobalamin Pharmacology
Mecobalamin + AdenosylcobalaminAbout Mecobalamin + AdenosylcobalaminN/AMechanism of Action of Mecobalamin + AdenosylcobalaminN/APharmacokinets of Mecobalamin + AdenosylcobalaminAbsorption: Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min
Excretion: Via urine.
Onset of Action for Mecobalamin + AdenosylcobalaminN/ADuration of Action for Mecobalamin + AdenosylcobalaminN/AHalf Life of Mecobalamin + AdenosylcobalaminN/ASide Effects of Mecobalamin + AdenosylcobalaminOral:
3.Vomiting and diarrhoea
4.Diaphoresis and pain/induration at IM inj site.
Potentially Fatal: Anaphylactoid reactions (parenteral)Contra-indications of Mecobalamin + AdenosylcobalaminN/ASpecial Precautions while taking Mecobalamin + AdenosylcobalaminN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Mecobalamin + Adenosylcobalamin1.Peripheral neuropathie
2.Megaloblastic anaemia caused by vit B12 deficiencyInteractions for Mecobalamin + Adenosylcobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine.
2.Reduced serum concentrations with oral contraceptives.
3.Reduced effects in anaemia with parenteral chloramphenicol.
Typical Dosage for Mecobalamin + Adenosylcobalamin1.Adult: PO Peripheral neuropathies 1,500 mcg/day in 3 divided doses
2.IV/IM Peripheral neuropathies 500 mcg/day 3 times/w
3.Megaloblastic anaemia caused by vit B12 deficiency 500 mcg/day 3 times/wk for about 2 mth. Maintenance: 500 mcg 1-3 mthly.Schedule of Mecobalamin + AdenosylcobalaminN/AStorage Requirements for Mecobalamin + AdenosylcobalaminN/AEffects of Missed Dosage of Mecobalamin + AdenosylcobalaminN/AEffects of Overdose of Mecobalamin + AdenosylcobalaminN/A
MecobalaminAbout MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/A
AdenosylcobalaminAbout AdenosylcobalaminN/AMechanism of Action of AdenosylcobalaminN/APharmacokinets of AdenosylcobalaminN/AOnset of Action for AdenosylcobalaminN/ADuration of Action for AdenosylcobalaminN/AHalf Life of AdenosylcobalaminN/ASide Effects of AdenosylcobalaminN/AContra-indications of AdenosylcobalaminN/ASpecial Precautions while taking AdenosylcobalaminN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Adenosylcobalamin1.Increasing muscle mass and strength.
2.Improving mental concentration.
Interactions for AdenosylcobalaminCobamamide has its effect reduced by chloramphenicolTypical Dosage for AdenosylcobalaminAs directed by thephysisionSchedule of AdenosylcobalaminN/AStorage Requirements for AdenosylcobalaminN/AEffects of Missed Dosage of AdenosylcobalaminN/AEffects of Overdose of AdenosylcobalaminN/A
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Mecobalamin + Adenosylcobalamin is a generic medicine name and there are several brands available for it. Some of the brands for mecobalamin + adenosylcobalamin might be better known than mecobalamin + adenosylcobalamin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mecobalamin + adenosylcobalamin in stock, you can ask for one of the branded alternatives for mecobalamin + adenosylcobalamin.