Diacerin + Aceclofenac Pharmacology

Diacerin + Aceclofenac

About Diacerin + Aceclofenac
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Mechanism of Action of Diacerin + Aceclofenac
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Pharmacokinets of Diacerin + Aceclofenac
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Onset of Action for Diacerin + Aceclofenac
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Duration of Action for Diacerin + Aceclofenac
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Half Life of Diacerin + Aceclofenac
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Side Effects of Diacerin + Aceclofenac
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Contra-indications of Diacerin + Aceclofenac
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Special Precautions while taking Diacerin + Aceclofenac
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Pregnancy Related Information
Contra indicated
Old Age Related Information
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Breast Feeding Related Information
Contra indicated
Children Related Information
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Indications for Diacerin + Aceclofenac
1.Ankylosing spondylitis
2.Rheumatoid arthritis
3.Osteoarthritis
Interactions for Diacerin + Aceclofenac
N/A
Typical Dosage for Diacerin + Aceclofenac
Twice daily
Schedule of Diacerin + Aceclofenac
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Storage Requirements for Diacerin + Aceclofenac
N/A
Effects of Missed Dosage of Diacerin + Aceclofenac
N/A
Effects of Overdose of Diacerin + Aceclofenac
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About
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Special Precautions while taking
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Indications for
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Typical Dosage for
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Schedule of
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Aceclofenac

About Aceclofenac
NSAID, Analgesic, Antiinflammatory, Anti arthritic.
Mechanism of Action of Aceclofenac
This drug has several mechanism of action.
1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action).
2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines.
3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production.
4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen.
5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs.
6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.
7. Aceclofenac is also an NSAID with greater COX-2 specificity
Pharmacokinets of Aceclofenac
Absorption- It is rapidly and completely absorbed after oral administration
Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma.
Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac
Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites
Onset of Action for Aceclofenac
N/A
Duration of Action for Aceclofenac
N/A
Half Life of Aceclofenac
The mean plasma elimination half-life is 4 - 4.3 hours
Side Effects of Aceclofenac
1. Dyspepsia
2. Abdominal pain
3. Dizziness
4. Vertigo
5. Pruritis
6. Rash
7. Dermatitis
8. Nausea
9. Diarrhoea
10. Flatulence
11. Gastritis
12. Constipation
13. Vomiting
14. Ulcerative stomatitis
15. Elevation of circulating levels of hepatic enzymes.
Contra-indications of Aceclofenac
1. Hypersensitivity to the drug
2. Bleeding from the stomach or intestines
3. Moderate to severely decreased kidney function
4. Hypersensitivity to other NSAIDs
5. Active peptic ulcer
Special Precautions while taking Aceclofenac
1. Hepatic porphyria
2. Bleeding tendencies
3. Blood disorders
4. Crohn`s disease
5. Decreased heart function
6. History of peptic ulcers
7. Inflammation of the bowel and back passage
8. Mildly decreased kidney function
9. Recent major surgery
10. Stomach disorders
11. Decreased liver function
12. Intestinal disorders
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
Indications for Aceclofenac
1. Ankylosing spondylitis
2. Osteoarthritis
3. Symptomatic treatment of pain and inflammation in Post-Traumatic pain
4. Cervical pain
5. Low back pain
6. Acute gout
Interactions for Aceclofenac
Lithium, digoxin and methotrexate: Aceclofenac may increase plasma concentrations of lithium, digoxin and methotrexate.
Anticoagulants: Activity of anticoagulants may be increased.
Diuretics : Aceclofenac inhibits the activity of diuretics. When concomitantly administrated with potassium sparing diuretics, serum potassium should be monitored.
Cyclosporin: Aceclofenac may enhance cyclosporin nephrotoxicity.
Quinolones : Aceclofenac may precipitate convulsions when coadministered with quinolone antibiotics.
Typical Dosage for Aceclofenac
Oral-
Adult (general dose)-
100mg twice daily
Schedule of Aceclofenac
H
Storage Requirements for Aceclofenac
Store below 25?C
Effects of Missed Dosage of Aceclofenac
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aceclofenac
Give symptomatic and supportive treatment. Induce gastric lavage and administer charcoal in repeated doses. Treated with antacid if necessary.

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Diacerin + Aceclofenac is a generic medicine name and there are several brands available for it. Some of the brands for diacerin + aceclofenac might be better known than diacerin + aceclofenac itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diacerin + aceclofenac in stock, you can ask for one of the branded alternatives for diacerin + aceclofenac.