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- Pharmacology For Naproxen + Pantoprazole
Naproxen + Pantoprazole Pharmacology
Naproxen + Pantoprazole
About Naproxen + PantoprazoleN/AMechanism of Action of Naproxen + PantoprazoleN/APharmacokinets of Naproxen + PantoprazoleN/AOnset of Action for Naproxen + PantoprazoleN/ADuration of Action for Naproxen + PantoprazoleN/AHalf Life of Naproxen + PantoprazoleN/ASide Effects of Naproxen + PantoprazoleN/AContra-indications of Naproxen + PantoprazoleN/ASpecial Precautions while taking Naproxen + PantoprazoleN/APregnancy Related InformationContra indicated in 3rd trimesterOld Age Related InformationN/ABreast Feeding Related InformationContra indicatedChildren Related InformationN/AIndications for Naproxen + Pantoprazole1.Pain or inflammation caused by conditions such as
2.Arthritis
3.Psoriatic Arthritis
4.Ankylosing Spondylitis
5.Tendinitis
6.Bursitis
7.Gout
8.Menstrual Cramps
9.Acute migraine attacks
Interactions for Naproxen + PantoprazoleN/ATypical Dosage for Naproxen + PantoprazoleN/ASchedule of Naproxen + PantoprazoleN/AStorage Requirements for Naproxen + PantoprazoleN/AEffects of Missed Dosage of Naproxen + PantoprazoleN/AEffects of Overdose of Naproxen + PantoprazoleN/ANaproxen
About NaproxenNSAID, 2-arylpropionic acid (profen) derivative, Analgesic, anti-inflammatory,antipyretic.Mechanism of Action of NaproxenNaproxen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Naproxen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of NaproxenAbsorption: Naproxen is well absorbed after oral administration and its bioavailability is about 95 %.
Distribution: It is distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: Naproxen and its metabolites are excreted mainly in the urine.
Onset of Action for Naproxen1 hoursDuration of Action for Naproxen7 hoursHalf Life of Naproxen10-20 hoursSide Effects of Naproxen1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastrointestinal bleeding
5. Abdominal pain
6. Constipation
7. Peptic ulceration
8. Dyspepsia
9. Headache
10. Drowsiness
11. Oedema
12. Agranulocytosis
13. Neutropenia
14. Thrombocytopenia
15. Dizziness
16. Rash
17. Pruritis
Contra-indications of Naproxen1. Hypersensitivity to Naproxen and other NSAIDs
2. Inflammatory bowel disease
3. Peptic ulcer
4. Severe renal impairment
Special Precautions while taking Naproxen1. Hepatic impairment
2. Renal impairment
3. Hypertension
4. Gastrointestinal diseases
5. Pre existing asthma
6. Oedema
7. Heart failure
8. Myocardial infarction
9. Stroke
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: ContraindicatedIndications for Naproxen1. Rheumatoid arthritis
2. Ankylosing spondylitis
3. Acute gout
4. Joint disorders e.g. inflammatory disease and crystal deposition in the joints
5. Osteoarthritis
6. For the relief of pain and inflammation in dental minor surgery and orthopedic
7. Dysmenorrhoea
8. Juvenile arthritis
9. Migraine
Interactions for NaproxenN/ATypical Dosage for NaproxenAdult: 500 - 1 g / day in 2 divided doses
Pain, Migraine, Dysmenorrhoea, Tendonitis, and Bursitis: Initial dose: 500 mg followed by 250 mg every 6 - 8 hours.
Maximum daily dose after first day: 1250mg
Acute gout: Initial dose: 750 mg followed by 250 mg every 8 hours until attack has subsided.
Children: 5 mg / kg body weight 2 times daily
Schedule of NaproxenHStorage Requirements for NaproxenStore Naproxen at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of NaproxenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NaproxenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Pantoprazole
About PantoprazoleA proton pump inhibitor, Benzimidazole derivative, Anti ulcer.Mechanism of Action of PantoprazolePantoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Pantoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Pantoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Pantoprazole is more acid stable and its activity is lowered in higher pH. It is the only proton pump inhibitor which is available as parenteral form.
Pharmacokinets of PantoprazoleAbsorption: Pantoprazole is well absorbed after oral administration. Its bioavailability is about 77% since it`s undergoes first pass metabolism.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Pantoprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Pantoprazole2-4 hoursDuration of Action for Pantoprazole1 dayHalf Life of Pantoprazole60 minutesSide Effects of Pantoprazole1. Diarrhoea
2. Nausea
3. Vomiting
4. Headache
5. Flatulence
6. Abdominal pain
7. Pruritis
8. Dizziness
9. Rash
Contra-indications of Pantoprazole1. Hypersensitivity to PantoprazoleSpecial Precautions while taking Pantoprazole1. Hepatic impairment
2. Monitor liver function
3. Avoid prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with caution
Below 12 years : Contraindicated
Indications for Pantoprazole1. Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
Interactions for PantoprazolePhenazone (antipyrine), diazepam, digoxin, theophylline, carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin, nifedipine, caffeine, metoprolol or ethanol : No clinically relevant interaction at therapeutic doses.
Oral contraceptives : Does not appear to compromise hormonal contraceptive efficacy as no interaction with a low dose combined oral contraceptive has been seen.
Typical Dosage for PantoprazoleOral :
Adult: 20-40mg / day before breakfast.
Duodenal ulcer: 40mg / day to be taken before breakfast for 2 - 4 weeks.
Benign Gastric ulcer: 40mg / day to be taken before breakfast for 1 - 2months.
Zollinger- Ellison syndrome: 80 mg / day in 2 divided doses increase the dose to 240 mg/ day if needed.
Gastroesophageal reflux disease: 20 - 40 mg / day to be taken before breakfast for 1 month and continue the treatment for 1 more month if needed.
Parenteral: 40 mg once daily as IV injection over 15 minutes.
Children below 12 years : Not recommended
Schedule of PantoprazoleHStorage Requirements for PantoprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of PantoprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PantoprazoleGive supportive measures and symptomatic treatment.Home Delivery for Naproxen + Pantoprazole in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including naproxen + pantoprazole.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for naproxen + pantoprazole and other medicines and health products. Home delivery services for naproxen + pantoprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take naproxen + pantoprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for naproxen + pantoprazole before they complete the sale. You can get this information while placing the order for naproxen + pantoprazole with the pharmacy.
Naproxen + Pantoprazole is a generic medicine name and there are several brands available for it. Some of the brands for naproxen + pantoprazole might be better known than naproxen + pantoprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have naproxen + pantoprazole in stock, you can ask for one of the branded alternatives for naproxen + pantoprazole.
