Drotaverine Pharmacology


About Drotaverine
Drotaverine is an effective spasmolytic drug.
Mechanism of Action of Drotaverine
Drotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.
Pharmacokinets of Drotaverine
Absorption: Drotaverine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: Extensively metabolised in the liver.
Excretion: It is excreted mainly with the bile.
Onset of Action for Drotaverine
30 minutes
Duration of Action for Drotaverine
4 hours.
Half Life of Drotaverine
7 - 12 hours
Side Effects of Drotaverine
Contra-indications of Drotaverine
1.Hypersensitivity to Drotaverine
2.Severe renal impairment
3.Severe hepatic impairment
4.Severe cardiac impairment
Special Precautions while taking Drotaverine
1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Drotaverine
1.Smooth muscle spasm
2.Gastrointestinal colic pain
3.Renal colic pain
5.Uterine neck spasm
6.Post MTP(Medical termination of pregnancy)
7.Post D&C(Dilatation and curettage)
8.Post surgical spasm
9.Irritable bowel syndrome
Interactions for Drotaverine
Typical Dosage for Drotaverine
Oral: 120 - 240 mg / day in 3 divided doses.
Children: 60 - 120 mg / day in 3 divided doses, dose is depending upon the age of the patient.
Parenteral (IM)
Induction of labour: 40 mg every 2 hours, maximum 3 doses.

Schedule of Drotaverine
Storage Requirements for Drotaverine
Store in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of Drotaverine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Drotaverine
Give supportive measures and symptomatic treatment.

Home Delivery for Drotaverine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including drotaverine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for drotaverine and other medicines and health products. Home delivery services for drotaverine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take drotaverine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for drotaverine before they complete the sale. You can get this information while placing the order for drotaverine with the pharmacy.

Drotaverine is a generic medicine name and there are several brands available for it. Some of the brands for drotaverine might be better known than drotaverine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drotaverine in stock, you can ask for one of the branded alternatives for drotaverine.