Choline Theophyllinate Pharmacology

Choline Theophyllinate

About Choline Theophyllinate
Choline salt of thophyllin
Mechanism of Action of Choline Theophyllinate
Oxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Oxtriphylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.
Pharmacokinets of Choline Theophyllinate
Absorption: Well absorbed from GI tract
Metabolism: Hepatic P450 enzyme CYP1A2, CYP3A4
Excretion: Urine
Onset of Action for Choline Theophyllinate
N/A
Duration of Action for Choline Theophyllinate
4-8 hr
Half Life of Choline Theophyllinate
4 hr
Side Effects of Choline Theophyllinate
1.Slight nausea
2.Decreased appetite
3.Weight loss
4.Restlessness
5.Tremor
6.Insomnia
7.Headache
8.Lightheadedness
9.Dizziness.
Contra-indications of Choline Theophyllinate
Hypersensitivity
Special Precautions while taking Choline Theophyllinate
1.Peptic ulceration
2.Hyperthyroidism
3.Hypertension
4.Cardiac arrhythmias or other cv diseases
5.Epilepsy
6.Hepatic dysfunction
7.Chronic alcoholism
8.Acute febrile illness
9.Smoking
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution,use minimum dose
Children Related Information
N/A
Indications for Choline Theophyllinate
Used to treat the symptoms of
1.Asthma
2.Bronchitis
3.Emphysema
Interactions for Choline Theophyllinate
The following drugs may increase the levels of oxtriphylline in your blood, leading to dangerous side effects:
1.Alcohol
2.Cimetidine
3.Fluoroquinolone antibiotics such as enoxacin, lomefloxacin,ciprofloxacin, norfloxacin (n, and ofloxacin
4.Clarithromycin and erythromycin
5.Disulfiram
6.Estrogens
7.Fluvoxamine
8.Methotrexate
9.Mexiletine and propafenone
10.Propranolol
11.Tacrine
12.Ticlopidine
13.Verapamil

The following drugs may decrease theophylline levels in your blood, leading to poor asthma control:
1.Aminoglutethimide
2.Carbamazepine
3.Isoproterenol
4.Moricizine
5.Phenobarbital
6.Phenytoin
7.Rifampin
8.Sucralfate
Typical Dosage for Choline Theophyllinate
400mg-600mg daily
Schedule of Choline Theophyllinate
N/A
Storage Requirements for Choline Theophyllinate
N/A
Effects of Missed Dosage of Choline Theophyllinate
Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

Effects of Overdose of Choline Theophyllinate
Seek emergency medical attention.
Symptoms of a oxtriphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.

Home Delivery for Choline Theophyllinate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including choline theophyllinate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for choline theophyllinate and other medicines and health products. Home delivery services for choline theophyllinate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take choline theophyllinate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for choline theophyllinate before they complete the sale. You can get this information while placing the order for choline theophyllinate with the pharmacy.

Choline Theophyllinate is a generic medicine name and there are several brands available for it. Some of the brands for choline theophyllinate might be better known than choline theophyllinate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have choline theophyllinate in stock, you can ask for one of the branded alternatives for choline theophyllinate.