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- Pharmacology For Drotaverine + Mefenamic acid
Drotaverine + Mefenamic acid Pharmacology
Drotaverine + Mefenamic acid
About Drotaverine + Mefenamic acidN/AMechanism of Action of Drotaverine + Mefenamic acidN/APharmacokinets of Drotaverine + Mefenamic acidN/AOnset of Action for Drotaverine + Mefenamic acidN/ADuration of Action for Drotaverine + Mefenamic acidN/AHalf Life of Drotaverine + Mefenamic acidN/ASide Effects of Drotaverine + Mefenamic acidN/AContra-indications of Drotaverine + Mefenamic acidN/ASpecial Precautions while taking Drotaverine + Mefenamic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Drotaverine + Mefenamic acidN/AInteractions for Drotaverine + Mefenamic acidN/ATypical Dosage for Drotaverine + Mefenamic acidN/ASchedule of Drotaverine + Mefenamic acidN/AStorage Requirements for Drotaverine + Mefenamic acidN/AEffects of Missed Dosage of Drotaverine + Mefenamic acidN/AEffects of Overdose of Drotaverine + Mefenamic acidN/ADrotaverine
About DrotaverineDrotaverine is an effective spasmolytic drug.Mechanism of Action of DrotaverineDrotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.Pharmacokinets of DrotaverineAbsorption: Drotaverine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: Extensively metabolised in the liver.
Excretion: It is excreted mainly with the bile.
Onset of Action for Drotaverine30 minutesDuration of Action for Drotaverine4 hours.Half Life of Drotaverine7 - 12 hoursSide Effects of Drotaverine1.Hypotension
2.Headache
3.Tachycardia
4.Nausea
5.Vertigo
Contra-indications of Drotaverine1.Hypersensitivity to Drotaverine
2.Severe renal impairment
3.Severe hepatic impairment
4.Severe cardiac impairment
Special Precautions while taking Drotaverine1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Drotaverine1.Smooth muscle spasm
2.Gastrointestinal colic pain
3.Renal colic pain
4.Dysmenorrhoea
5.Uterine neck spasm
6.Post MTP(Medical termination of pregnancy)
7.Post D&C(Dilatation and curettage)
8.Post surgical spasm
9.Irritable bowel syndrome
Interactions for DrotaverineN/ATypical Dosage for DrotaverineAdult:
Oral: 120 - 240 mg / day in 3 divided doses.
Children: 60 - 120 mg / day in 3 divided doses, dose is depending upon the age of the patient.
Parenteral (IM)
Induction of labour: 40 mg every 2 hours, maximum 3 doses.
Schedule of DrotaverineN/AStorage Requirements for DrotaverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of DrotaverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DrotaverineGive supportive measures and symptomatic treatment.Mefenamic Acid
About Mefenamic AcidNSAID, Analgesic,antiinflammatory.Mechanism of Action of Mefenamic AcidMefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of Mefenamic AcidAbsorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.Onset of Action for Mefenamic Acid1-2 hours.Duration of Action for Mefenamic Acid6 hours.Half Life of Mefenamic Acid2-4 hours.Side Effects of Mefenamic Acid1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Peptic ulcer
9.Dyspepsia
10.Headache
11.Flatulence
12.Drowsiness
13.Insomnia
14.Agranulocytosis
15.Aplastic anaemia
16.Thrombocytopenia
17.Dizziness
18.Rash
Contra-indications of Mefenamic Acid1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
3.Peptic ulcer
Special Precautions while taking Mefenamic Acid1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Patient on anticoagulant therapy
7.Heart failure
8.Myocardial infarction
9.StrokePregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid1.Muscular aches
2.Primary Dysmenorrhoea
3.Headaches
4.Acute gout
5.Dental pain
6.Patent ductus arteriosus
Interactions for Mefenamic AcidN/ATypical Dosage for Mefenamic AcidAdult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.
Schedule of Mefenamic AcidHStorage Requirements for Mefenamic AcidStore Mefenamic acid at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Mefenamic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Mefenamic AcidGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.
Home Delivery for Drotaverine + Mefenamic acid in Your City
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Drotaverine + Mefenamic acid is a generic medicine name and there are several brands available for it. Some of the brands for drotaverine + mefenamic acid might be better known than drotaverine + mefenamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drotaverine + mefenamic acid in stock, you can ask for one of the branded alternatives for drotaverine + mefenamic acid.
