Olmesartan + Amlodipine Pharmacology

Olmesartan + Amlodipine

About Olmesartan + Amlodipine
N/A
Mechanism of Action of Olmesartan + Amlodipine
N/A
Pharmacokinets of Olmesartan + Amlodipine
N/A
Onset of Action for Olmesartan + Amlodipine
N/A
Duration of Action for Olmesartan + Amlodipine
N/A
Half Life of Olmesartan + Amlodipine
N/A
Side Effects of Olmesartan + Amlodipine
1.Edema
2.Hypotension
3.Orthostatic Hypotension
4.Rash
5.Pruritus,
6.Palpitation
7.Urinary Frequency
8.Nocturia.
Contra-indications of Olmesartan + Amlodipine
1.Hypersensitivity to olmesartan medoxomil or amlodipine
2.Congestive Heart Failure
Special Precautions while taking Olmesartan + Amlodipine
1.Hepatic Insufficiency: Patients with hepatic insufficiency have decreased
clearance of amlodipine
2.Heart Failure: Patients with heart failure have decreased clearance of
amlodipine
3.Patients, particularly those with severe obstructive coronary artery disease, may
develop increased frequency, duration, or severity of angina or acute myocardial
infarction on starting calcium channel blocker therapy or at the time of dosage
increase.
4.Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Low dose may be needed.
Breast Feeding Related Information
Use only when potential benefit.
Children Related Information
N/A
Indications for Olmesartan + Amlodipine
Hypertension
Interactions for Olmesartan + Amlodipine
N/A
Typical Dosage for Olmesartan + Amlodipine
One tablet once-daily. Maximum antihypertensive effects are
attained within 2 weeks after change in dose. The dose may be increased after 1
to 2-weeks of therapy depending on the response and tolerability. The total daily
dose should not exceed two tablets.

Schedule of Olmesartan + Amlodipine
N/A
Storage Requirements for Olmesartan + Amlodipine
N/A
Effects of Missed Dosage of Olmesartan + Amlodipine
N/A
Effects of Overdose of Olmesartan + Amlodipine
N/A

Olmesartan

About Olmesartan
An angiotensin II receptor antagonist, Imidazole derivative, Antihypertensive.
Mechanism of Action of Olmesartan
Olmesartan is a competitive antagonist of angiotensin-II at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-II such as: - Vasoconstriction, Central & Peripheral sympathetic stimulus, Release of aldosterone and adrenaline, Salt and water reabsorption and Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels and at last produces lowering of blood pressure.
Pharmacokinets of Olmesartan
Absorption: It is rapidly and completely absorbed after oral administration.
Metabolism: It undergoes metabolism in the liver.
Excretion: It is excreted primarily in urine and small amount in urine.
Onset of Action for Olmesartan
N/A
Duration of Action for Olmesartan
N/A
Half Life of Olmesartan
13 hours
Side Effects of Olmesartan
1.Dizziness
2.Headache
3.Diarrhea
4.Upper respiratory tract infection
5.Abnormal heart rate
6.Chest pain
7.Peripheral edema
8.Vertigo
9.Abdominal pain
10.Dyspepsia
11.Nausea
12.Hypercholesterolemia
13.Hyperuricemia
14.Arthralgia
15.Arthritis
16.Myalgia
17.Rash
18.Facial edema
Contra-indications of Olmesartan
Hypersensitivity to Olmesartan
Special Precautions while taking Olmesartan
1.Renal impairment
2.Renal artery stenosis
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Olmesartan
Hypertension
Interactions for Olmesartan
N/A
Typical Dosage for Olmesartan
Adult: 20mg/day and if needed dose can be increased to 40mg/day
Schedule of Olmesartan
N/A
Storage Requirements for Olmesartan
Store at 20 - 25 degree C. Keep out of the reach of children. Keep away from heat, light and moisture.
Effects of Missed Dosage of Olmesartan
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Olmesartan
Give supportive measures and symptomatic treatment.

Amlodipine

About Amlodipine
Calcium Channel Blocker, Anti hypertensive,anti angina.
Mechanism of Action of Amlodipine
Amlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.
Pharmacokinets of Amlodipine
Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.
Onset of Action for Amlodipine
Slow
Duration of Action for Amlodipine
24 hours
Half Life of Amlodipine
N/A
Side Effects of Amlodipine
1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine
1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine
1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
Contraindicated
Indications for Amlodipine
1.Hypertension
2.Prinzmetal`s angina
3.Stable angina
Interactions for Amlodipine
ACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.
Typical Dosage for Amlodipine
5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
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Schedule of Amlodipine
H
Storage Requirements for Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.

Effects of Missed Dosage of Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Amlodipine
Monitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.

Home Delivery for Olmesartan + Amlodipine in Your City

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Olmesartan + Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for olmesartan + amlodipine might be better known than olmesartan + amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have olmesartan + amlodipine in stock, you can ask for one of the branded alternatives for olmesartan + amlodipine.