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- Pharmacology For Omeprazole + Cinitapride
Omeprazole + Cinitapride Pharmacology
Omeprazole + Cinitapride
About Omeprazole + CinitaprideN/AMechanism of Action of Omeprazole + CinitaprideN/APharmacokinets of Omeprazole + CinitaprideN/AOnset of Action for Omeprazole + CinitaprideN/ADuration of Action for Omeprazole + CinitaprideN/AHalf Life of Omeprazole + CinitaprideN/ASide Effects of Omeprazole + CinitaprideN/AContra-indications of Omeprazole + CinitaprideN/ASpecial Precautions while taking Omeprazole + CinitaprideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Omeprazole + CinitaprideFor the treatment of gastirc ulcer,gastroesophageal reflux disease(GERD) & Dyspepsia not responding to omeprazole alone.Interactions for Omeprazole + CinitaprideN/ATypical Dosage for Omeprazole + CinitaprideN/ASchedule of Omeprazole + CinitaprideN/AStorage Requirements for Omeprazole + CinitaprideN/AEffects of Missed Dosage of Omeprazole + CinitaprideN/AEffects of Overdose of Omeprazole + CinitaprideN/AOmeprazole
About OmeprazoleProton Pump Inhibitor, Substituted Benzimidazole, Anti-secretory,antiulcer.Mechanism of Action of OmeprazoleOmeprazole is a proton pump inhibitor and it is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Omeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Omeprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion.
Pharmacokinets of OmeprazoleAbsorption: Omeprazole is well absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Omeprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the faeces and small amount in urine.
Onset of Action for Omeprazole2- 5 hoursDuration of Action for Omeprazole1 dayHalf Life of Omeprazole30 - 90 minutesSide Effects of Omeprazole1. Diarrhoea
2. Nausea
3. Vomiting
4. Abdominal pain
5. Constipation
6. Flatulence
7. Headache
8. Dry mouth
9. Dizziness
10. Myalgia
11. Rash
.Contra-indications of Omeprazole1. Hypersensitivity to OmeprazoleSpecial Precautions while taking Omeprazole1. Hepatic impairment
2. Monitor gastric malignancy
3. Avoid prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: Contraindicated
Indications for Omeprazole1. Duodenal ulcer
2. Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
5. Oesophagitis
6. Acid related dyspepsia
7. NSAID associated ulceration
8. Prophylaxis of acid aspiration during anesthesia
Interactions for OmeprazoleDiazepam: Half life of diazepam is increased.
Phenytoin: Increased plasma concentration of phenytoin.
Oral Anticoagulants: May prolong the elimination of warfarin.
Cyclosporine, Disulfiram: Omeprazole interferes with the metabolism of these drugs.
Ketaconazole, Ampicillin esters, Iron Salts: Omeprazole may interfere with the absorption of these drugs where gastric pH is a determinant of their bio-availability.Typical Dosage for OmeprazoleOral :
Adult: 10 - 20 mg / day to be taken before meals.
Duodenal ulcer: 20 mg / day to be taken 30 minutes before meals for 1-2 months.
Gastric ulcer: 20 mg / day for 1-2 months.In severe cases dose can be increased to 40 mg / day. Maintenance dose: 10 - 20 mg / day.
Zollinger- Ellison syndrome: 60 mg / day increase the dose maximum up to 360 mg/ day in 3 divided doses if needed.
Gastroesophageal reflux disease, oesophagitis: 20 mg / day for 1-2 months.
Acid related dyspepsia: 10 - 20 mg / day for 1 month.
NSAID associated ulceration: 20mg / day for 1 month.
Prophylaxis of acid aspiration during anesthesia: 40 mg in the evening before the surgery and the same dose 2 - 6 hours before the procedure.
Children: Not recommended
Schedule of OmeprazoleHStorage Requirements for OmeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of OmeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OmeprazoleGive supportive measures and symptomatic treatment.Cinitapride
About CinitaprideCinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class.Mechanism of Action of CinitaprideCinitapride is a substituted benzamide with 5-HT receptor antagonist and agonist activity.Pharmacokinets of CinitaprideWell absorbed orally am i.mOnset of Action for CinitaprideN/ADuration of Action for CinitaprideN/AHalf Life of Cinitapride3-5 h during the first 8 h and a residual half-life greater than 15 h thereafter.Side Effects of Cinitapride1.Most Common - Drowsiness and diarrhea.
2.Central Nervous System - Involuntary muscular movements of the head, neck and tongue.
3.Skin - Rarely eruptions, itching or allergic reactions
Contra-indications of CinitaprideN/ASpecial Precautions while taking Cinitapride1.Caution should be exercised in patients with history of gastrointestinal bleeding, mechanical obstruction or perforation, movement disorder, during pregnancy and breastfeeding.
2.Avoid alcohol consumption.
3.It may cause drowsiness, do not drive a car or operate machinery while taking this medication.
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Cinitapride For the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying.Interactions for Cinitapride1.Atropine Anticholinergic agents like atropine may reduce the action of cinitapride.
2.Digoxin Cinitapride can alter the absorption of digoxin as it simulates gastric
emptying.
Typical Dosage for CinitaprideThe usual daily dosage for adults is 1mg orally thrice a day, 15 minutes before meals.Schedule of CinitaprideN/AStorage Requirements for CinitaprideKeep in a cool dry place.Effects of Missed Dosage of CinitaprideN/AEffects of Overdose of CinitaprideN/AHome Delivery for Omeprazole + Cinitapride in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for omeprazole + cinitapride and other medicines and health products. Home delivery services for omeprazole + cinitapride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Omeprazole + Cinitapride is a generic medicine name and there are several brands available for it. Some of the brands for omeprazole + cinitapride might be better known than omeprazole + cinitapride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have omeprazole + cinitapride in stock, you can ask for one of the branded alternatives for omeprazole + cinitapride.
