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- Pharmacology For Drotaverine + Nimesulide
Drotaverine + Nimesulide Pharmacology
Drotaverine + Nimesulide
About Drotaverine + NimesulideN/AMechanism of Action of Drotaverine + NimesulideN/APharmacokinets of Drotaverine + NimesulideN/AOnset of Action for Drotaverine + NimesulideN/ADuration of Action for Drotaverine + NimesulideN/AHalf Life of Drotaverine + NimesulideN/ASide Effects of Drotaverine + NimesulideN/AContra-indications of Drotaverine + NimesulideN/ASpecial Precautions while taking Drotaverine + NimesulideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Drotaverine + NimesulideN/AInteractions for Drotaverine + NimesulideN/ATypical Dosage for Drotaverine + NimesulideN/ASchedule of Drotaverine + NimesulideN/AStorage Requirements for Drotaverine + NimesulideN/AEffects of Missed Dosage of Drotaverine + NimesulideN/AEffects of Overdose of Drotaverine + NimesulideN/ADrotaverine
About DrotaverineDrotaverine is an effective spasmolytic drug.Mechanism of Action of DrotaverineDrotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.Pharmacokinets of DrotaverineAbsorption: Drotaverine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: Extensively metabolised in the liver.
Excretion: It is excreted mainly with the bile.
Onset of Action for Drotaverine30 minutesDuration of Action for Drotaverine4 hours.Half Life of Drotaverine7 - 12 hoursSide Effects of Drotaverine1.Hypotension
2.Headache
3.Tachycardia
4.Nausea
5.Vertigo
Contra-indications of Drotaverine1.Hypersensitivity to Drotaverine
2.Severe renal impairment
3.Severe hepatic impairment
4.Severe cardiac impairment
Special Precautions while taking Drotaverine1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Drotaverine1.Smooth muscle spasm
2.Gastrointestinal colic pain
3.Renal colic pain
4.Dysmenorrhoea
5.Uterine neck spasm
6.Post MTP(Medical termination of pregnancy)
7.Post D&C(Dilatation and curettage)
8.Post surgical spasm
9.Irritable bowel syndrome
Interactions for DrotaverineN/ATypical Dosage for DrotaverineAdult:
Oral: 120 - 240 mg / day in 3 divided doses.
Children: 60 - 120 mg / day in 3 divided doses, dose is depending upon the age of the patient.
Parenteral (IM)
Induction of labour: 40 mg every 2 hours, maximum 3 doses.
Schedule of DrotaverineN/AStorage Requirements for DrotaverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of DrotaverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DrotaverineGive supportive measures and symptomatic treatment.Nimesulide
About NimesulideCOX-2 selective NSAID, Analgesic,antipyretic.Mechanism of Action of NimesulideThis Non Steroidal Anti Inflammatory Drug reduces prostaglandin synthesis by the inhibition of cyclo oxygenase enzyme2 selectively. This is a weaker inhibition .So it produces weaker analgesic property. Its potent anti-inflammatory activity is due to its action on various stages of inflammation. This leads to the inhibition of super oxide anion formation invitro by activated neutrophil, inhibition of histamine release from tissue mast cells and basophiles. Additionally it also prevents platelet activating factor synthesis and metalloproteinase synthesis thus prevents the breakdown of osteoarthritic human cartilage. It also prevent tumor necrosis factor alpha and thus reduce the formation of cytokines. This drug can activate glucocorticoid receptors in the body.Pharmacokinets of NimesulideAbsorption-Completely absorbed after oral administration.
Distribution-Widely distributed in the body and extensively bind to the plasma proteins i.e.99%.
Metabolism-It is metabolized in liver to its metabolites.4-hydroxyl derivative is its one active metabolite.
Excretion - Excreted via urine and bile.
Onset of Action for Nimesulide30 to 60 minutesDuration of Action for Nimesulide8-10 hoursHalf Life of NimesulideIts plasma half life is long-nearly 2daysSide Effects of Nimesulide1. Nausea
2. Vomiting
3. Diarrhea
4. Heart burn
5. Epigastric pain
6. Pruritis
7. Skin rash
8. Headache
9. Dizziness
10.Somnolence
Contra-indications of Nimesulide1. Hypersensitivity to this drug
2. Active peptic ulcer
3. Hepatic impairment
Special Precautions while taking Nimesulide1. Renal impairment
2. Heart failure
3. Alcohol abuse
4. Colitis
5. Crohns disease
6. Diverticulitis
7. Gastric ulcer
8. Diabetis mellitus
9. Hemarrhoids
10. Hepatic failure
11. Rectal irritation or bleeding
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Nimesulide1. Painful inflammatory conditions associated with -
Musculoskeletal system, Dysmenorrhea, Thrombophlebitis, Gout
2. Dental pain
3. ENT infection
4. Osteoarthritis
5. Rheumatoid arthritis
6. Gynecological disorder
7. Low back pain
8. Post operative pain
9. Fever
Interactions for NimesulideFenofibrate, Salicyclic acid, Valproic acid and Tolbutamide: These drugs displace nimesulide from the plasma binding sites.
Methotrexate and Frusemide: These drugs may be displaced from plasma proteins by nimesulide.
Warfarin: Exercise caution since efficacy may be increased.
Theophylline: Efficacy of slow release theophylline preparations reduced. Typical Dosage for NimesulideOral-
Adults - 100 mg two times daily.
Children - 5mg/kg/day divided in 2 or 3 doses.
Schedule of NimesulideHStorage Requirements for NimesulideStore in cool, dark, dry placeEffects of Missed Dosage of NimesulideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of NimesulideEmpty the stomach if necessary. Symptomatic treatment should be given
Home Delivery for Drotaverine + Nimesulide in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including drotaverine + nimesulide.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for drotaverine + nimesulide and other medicines and health products. Home delivery services for drotaverine + nimesulide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take drotaverine + nimesulide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for drotaverine + nimesulide before they complete the sale. You can get this information while placing the order for drotaverine + nimesulide with the pharmacy.
Drotaverine + Nimesulide is a generic medicine name and there are several brands available for it. Some of the brands for drotaverine + nimesulide might be better known than drotaverine + nimesulide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drotaverine + nimesulide in stock, you can ask for one of the branded alternatives for drotaverine + nimesulide.
