Prednisolone + Moxifloxacin Pharmacology

Prednisolone + Moxifloxacin

About Prednisolone + Moxifloxacin
N/A
Mechanism of Action of Prednisolone + Moxifloxacin
The antibacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV.DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Prednisolone acetate is a corticosteroid (anti-inflammatory agent) inhibits the edema, fibrin deposition, capillary dilation and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen and scar formation.
Pharmacokinets of Prednisolone + Moxifloxacin
N/A
Onset of Action for Prednisolone + Moxifloxacin
N/A
Duration of Action for Prednisolone + Moxifloxacin
N/A
Half Life of Prednisolone + Moxifloxacin
N/A
Side Effects of Prednisolone + Moxifloxacin
1.Conjunctival irritation
2.Increased lacrimation
3.Keratitis and papillary conjunctivitis
Contra-indications of Prednisolone + Moxifloxacin
1.In epithelial herpes simplex keratitis (Dendritic keratitis).
2.Vaccinia, varicella, and in many other viral diseases of the conjunctiva and cornea.
3.Mycobacterial infection of the eye
4.Fungal diseases of ocular structures
5.Individuals hypersensitive to any of the components of the medication.
Special Precautions while taking Prednisolone + Moxifloxacin
Prolonged use of steroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation.
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Prednisolone + Moxifloxacin
Post-operative inflammation and any other ocular inflammation associated with infection.
Interactions for Prednisolone + Moxifloxacin
N/A
Typical Dosage for Prednisolone + Moxifloxacin
N/A
Schedule of Prednisolone + Moxifloxacin
N/A
Storage Requirements for Prednisolone + Moxifloxacin
Store in a cool place. Protect from light.
Effects of Missed Dosage of Prednisolone + Moxifloxacin
N/A
Effects of Overdose of Prednisolone + Moxifloxacin
N/A

Prednisolone

About Prednisolone
Systemic synthetic Glucocorticoid, Immunosuppressant.
Mechanism of Action of Prednisolone
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action with little mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction

Pharmacokinets of Prednisolone
Absorption: Well absorbed orally, Distribution: Drug is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine. It crosses the placenta and also secreted in breast milk, Metabolism: Metabolized in liver in to inactive metabolites by glucuronide and sulfate conjugation. Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
Onset of Action for Prednisolone
2 to 4 days
Duration of Action for Prednisolone
Half to 3days
Half Life of Prednisolone
18 to 36hours
Side Effects of Prednisolone
1.Susceptibility to infection
2.Peptic ulcer
3.Haemorrhage
4.Glycosuria
5.Hyperglycaemia
6.Osteoporosis
7.Atrophy of adrenal cortex(on prolonged therapy)
8.Suppression of adrenocorticotropic hormone
9.Cushing`s syndrome
10.Inhibition of growth in children
11.Amenorrhoea
12.Behavioral disturbances
13.Thromboembolic disorders
14.Myopathy
15.Weakness
16.Lymphocytopenia
17.Muscle wasting
18.Gastrointestinal discomfort
19.Increased appetite
20.Delayed wound healing
21.Headache
22.Euphoria
23.Insomnia
24.Seizures
25.Heart failure
26.Arrhythmias
27.Posterior sub capsular cataract
28.Glaucoma
29.Increased intracranial pressure

Contra-indications of Prednisolone
1.Hypersensitivity to the drug
2.Peptic ulcer
3.Systemic Infections
4.Fungal infections
5.Live vaccines

Special Precautions while taking Prednisolone
1.Avoid sudden discontinuation of the drug
2.Tuberculosis
3.Osteoporosis
4.Ocular herpes simplex
5.Primary glaucoma
6.Peptic ulcer
7.Primary psychosis and psychoneurosis
8.Recent myocardial infarction
9.Heart failure
10.Diabetes mellitus
11.Hypothyroidism
12.Cirrhosis
13.Stress
14.Sepsis
15.Hypertension
16.Myasthenia gravis
17.Renal impairment
18.Hepatic impairment
19.Non specific Ulcerative colitis
20.Diverticulitis
21.Recent intestinal anastomosis
22.Seizures
23.Thromboembolic disorders

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution.
Neonates: Contraindicated
Indications for Prednisolone
1.Allergic conditions
2.Anaphylaxis
3.Inflammatory conditions
4.Rheumatic disorders
5.Autoimmune diseases
6.Asthma
7.Inflammatory bowel disease
8.Malignancies
9.Acute gout

Interactions for Prednisolone
Barbiturates: Decrease pharmacologic of prednisolone.
Oral contraceptives: May increase concentration of prednisolone.
Oestrogens: May decrease the clearance of prednisolone.
Ketoconazole: Increases efficacy of prednisolone.
Rifampicin: Decreases efficacy.
Prednisolone affects the actions of the following:
Anticholinesterases: Effects may be antagonised in myasthenia gravis.
Cyclosporine: May lead to enhanced toxicity.
Digitalis glycosides: May lead to enhanced toxicity.
Isoniazid: Decreased serum levels of isoniazid.
Salicylates: Decreased serum levels of salicylate.
Diuretics: May cuase hypokalaemia and increased hyperglycaemia.
Non-depolarising muscle relaxants: Altered response.
Somatrem: Growth promoting effect inhibited.
Theophyllines: Altered response of either agent.
IUCD: contraceptive failure.
Lab. Tests:
a) Increases serum cholesterol levels.
b) Increases urine glucose levels.
c) Decreases Thyroid I131 uptake; Decreases T3 serum levels.
d) Decreases serum potassium.
Typical Dosage for Prednisolone
Oral: 10 to 60mg/day; depending up on the severity of the condition and patient`s response.
Children: 0.15 to 2mg/kg/day in 4 to 6 divided doses; depending up on the severity of the condition and patient`s response.
I.M. or I.V.: 2 to 30mg 12th hourly
Intra-articular: 5 to 25mg Prednisolone acetate.

Schedule of Prednisolone
H
Storage Requirements for Prednisolone
Store at room temperature below 30 degree C. Protect from light and moisture. Keep out of reach of children.
Effects of Missed Dosage of Prednisolone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Prednisolone
Provide symptomatic treatment and supportive measures.

Moxifloxacin

About Moxifloxacin
A third generation synthetic fluoroquinolone Antibiotic, A broad spectrum antibiotic.
Mechanism of Action of Moxifloxacin
Moxifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Moxifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Moxifloxacin
Absorption: They are adequately absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes hepatic metabolism. Excretion: Drug is excreted mainly through urine.

Onset of Action for Moxifloxacin
N/A
Duration of Action for Moxifloxacin
N/A
Half Life of Moxifloxacin
N/A
Side Effects of Moxifloxacin
1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Dizziness
6.Drowsiness
7.Rash
8.Headache
9.Photosensitivity
Contra-indications of Moxifloxacin
1.Hypersensitivity to Moxifloxacin and other Fluoroquinolones.
Special Precautions while taking Moxifloxacin
1.Hepatic impairment
2.Renal impairment
3.Seizure
4.Concomitant use of antiarrhythmic drugs.
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Moxifloxacin
1.Pneumonia
2.Bronchitis
3.Sinusitis
4.Skin infections
Interactions for Moxifloxacin
Antiarrhythmic agents (amiodarone, bretylium, disopyramide, procainamide, quinidine, sotalol): The risk of threatening cardiac arrhythmias may be increased.
Typical Dosage for Moxifloxacin
Adults: 400 mg once daily for 5 - 10 days
Dose is determined on the basis of severity of the infection, type of infecting organism.
Schedule of Moxifloxacin
H
Storage Requirements for Moxifloxacin
Store at room temperature in a tightly closed container.
Effects of Missed Dosage of Moxifloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Moxifloxacin
Give supportive measures and symptomatic treatment.

Home Delivery for Prednisolone + Moxifloxacin in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for prednisolone + moxifloxacin and other medicines and health products. Home delivery services for prednisolone + moxifloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

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Prednisolone + Moxifloxacin is a generic medicine name and there are several brands available for it. Some of the brands for prednisolone + moxifloxacin might be better known than prednisolone + moxifloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have prednisolone + moxifloxacin in stock, you can ask for one of the branded alternatives for prednisolone + moxifloxacin.