Botulinum Injection Pharmacology

Botulinum Injection

About Botulinum Injection
Neurotoxin ob tained from Clostridium botulinum
Mechanism of Action of Botulinum Injection
Botox blocks neuromuscular conduction by binding to receptor sites on motor nerve terminals, entering the nerve terminals and inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within nerve endings.
Pharmacokinets of Botulinum Injection
Onset of Action for Botulinum Injection
Duration of Action for Botulinum Injection
Half Life of Botulinum Injection
Side Effects of Botulinum Injection
1.Temporary weakness in the group of muscles being treated.
2.Flu-like symptoms develop in some, but rarely.
Contra-indications of Botulinum Injection
Botulinum toxin type A purified neurotoxin complex is contraindicated in individuals with known hypersensitivity to any ingredient in the formulation.
Special Precautions while taking Botulinum Injection
1.Do not exceed the recommended dosage and frequency of administration of Botox
2.The safe and effective use of Botox depends upon proper storage of the product, selection of the correct dose, and proper reconstitution and administration techniques
Pregnancy Related Information
Not recommended
Old Age Related Information
Low dose should be used
Breast Feeding Related Information
Use with caution
Children Related Information
Safety and effectiveness in children <12 years has not been established.
Indications for Botulinum Injection
1.Treatment of strabismus & blepharospasm associated with dystonia, benign essential blepharospasm or VII nerve disorders in patient ?12 yr.
2.Temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator &/or procerus muscle activity in adult <65 y
Interactions for Botulinum Injection
Certain antibiotics (e.g., aminoglycosides such as gentamicin, polymyxin), anticoagulants (e.g., warfarin), Alzheimer's disease drugs (e.g., donepezil, galantamine, rivastigmine, tacrine), myasthenia gravis drugs (e.g., ambenonium, pyridostigmine), quinidine.
Typical Dosage for Botulinum Injection
Schedule of Botulinum Injection
Storage Requirements for Botulinum Injection
Store unopened vial in refrigerator (2-8?C). Administer Botox within 4 hrs after the vial is removed from the refrigerator and reconstituted. During these 4 hrs, reconstituted Botox should be clear, colorless and free of particulate matter.
Effects of Missed Dosage of Botulinum Injection
Effects of Overdose of Botulinum Injection
Signs and symptoms of overdose are not apparent immediately after post-injection. When accidental injection or oral ingestion occurs, the person should be medically supervised for up to several weeks for signs and symptoms of systemic weakness or muscle paralysis.
The antitoxin will not reverse any botulinum toxin-induced muscle weakness effects already apparent by the time of antitoxin administration.

Home Delivery for Botulinum Injection in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including botulinum injection.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for botulinum injection and other medicines and health products. Home delivery services for botulinum injection may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take botulinum injection only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for botulinum injection before they complete the sale. You can get this information while placing the order for botulinum injection with the pharmacy.

Botulinum Injection is a generic medicine name and there are several brands available for it. Some of the brands for botulinum injection might be better known than botulinum injection itself. If the pharmacy that's willing to deliver medicines to your home doesn't have botulinum injection in stock, you can ask for one of the branded alternatives for botulinum injection.