Varenicline Tartrate Pharmacology

Varenicline Tartrate

About Varenicline Tartrate
Nicotinic Receptor partial agonist
Mechanism of Action of Varenicline Tartrate
Varenicline is a partial agonist of the ?4?2 subtype of the nicotinic acetylcholine receptor. In addition it acts on ?3?4 and weakly on ?3?2 and ?6-containing receptors. A full agonism was displayed on ?7-receptors. Acting as a partial agonist varenicline binds to, and partially stimulates, the ?4?2 receptor without producing a full effect like nicotine. Thus varenicline does not greatly increase the downstream release of dopamine. Due to its competitive binding on these receptors, varenicline blocks the ability of nicotine to bind and stimulate the mesolimbic dopamine system, akin to the action of buprenorphine in the treatment of opioid addiction.
Varenicline also acts as an agonist at 5-HT3 receptors, which may contribute to mood altering effects of varenicline
Pharmacokinets of Varenicline Tartrate
Distribution:Protein binding Less than 20%
Onset of Action for Varenicline Tartrate
Duration of Action for Varenicline Tartrate
Half Life of Varenicline Tartrate
24 hours
Side Effects of Varenicline Tartrate
6.Sleep disturbances
7.Increased appetite
8.GI disturbances including vomiting, constipation and flatulence.
9.Potentially dangerous: suicidal ideation and occasional suicidal behavior, erratic behavior
Contra-indications of Varenicline Tartrate
Special Precautions while taking Varenicline Tartrate
1.Monitor for signs of suicidal ideation or behaviour, or changes in behaviour.
2.May affect performance of skilled tasks.
Pregnancy Related Information
Contra indicated
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended for use in children <18 yr.
Indications for Varenicline Tartrate
To treat smoking addiction.
Interactions for Varenicline Tartrate
Cimetidine may increase the plasma levels of varenicline.
Typical Dosage for Varenicline Tartrate
Adult: PO 0.5 mg once daily for 1st 3 days, followed by 0.5 mg twice daily for the next 4 days. Maintenance (wk 2-12): 1 mg twice daily. Initiate dose 1-2 wk before target quit date. Usual treatment duration: 12 wk. May continue for another 12 wk to reduce relapse in patients who have successfully quitted after the initial treatment course.
Renal impairment: Haemodialysis: Max: 500 mcg once daily.
Schedule of Varenicline Tartrate
Storage Requirements for Varenicline Tartrate
Oral: Store between 15-30?C.
Effects of Missed Dosage of Varenicline Tartrate
Effects of Overdose of Varenicline Tartrate
General supportive measures should be instituted.

Home Delivery for Varenicline Tartrate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for varenicline tartrate and other medicines and health products. Home delivery services for varenicline tartrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take varenicline tartrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for varenicline tartrate before they complete the sale. You can get this information while placing the order for varenicline tartrate with the pharmacy.

Varenicline Tartrate is a generic medicine name and there are several brands available for it. Some of the brands for varenicline tartrate might be better known than varenicline tartrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have varenicline tartrate in stock, you can ask for one of the branded alternatives for varenicline tartrate.