Drotaverine + Paracetamol Pharmacology

Drotaverine + Paracetamol

About Drotaverine + Paracetamol
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Mechanism of Action of Drotaverine + Paracetamol
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Pharmacokinets of Drotaverine + Paracetamol
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Onset of Action for Drotaverine + Paracetamol
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Duration of Action for Drotaverine + Paracetamol
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Half Life of Drotaverine + Paracetamol
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Side Effects of Drotaverine + Paracetamol
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Contra-indications of Drotaverine + Paracetamol
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Special Precautions while taking Drotaverine + Paracetamol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Drotaverine + Paracetamol
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Interactions for Drotaverine + Paracetamol
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Typical Dosage for Drotaverine + Paracetamol
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Schedule of Drotaverine + Paracetamol
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Storage Requirements for Drotaverine + Paracetamol
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Effects of Missed Dosage of Drotaverine + Paracetamol
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Effects of Overdose of Drotaverine + Paracetamol
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Drotaverine

About Drotaverine
Drotaverine is an effective spasmolytic drug.
Mechanism of Action of Drotaverine
Drotaverine has spasmolytic and vasodilating action. It exerts its action by inhibiting phosphodiesterase enzyme IV. This will leads to a decrease in cyclic AMP level and reduction in calcium ions (Ca2+). The reduction of calcium ions will dilates the unstipped muscles and blood vessels strongly and relieves spasm of smooth muscles.
Pharmacokinets of Drotaverine
Absorption: Drotaverine is rapidly absorbed after oral administration.
Distribution: It is widely distributed in protein bound form.
Metabolism: Extensively metabolised in the liver.
Excretion: It is excreted mainly with the bile.
Onset of Action for Drotaverine
30 minutes
Duration of Action for Drotaverine
4 hours.
Half Life of Drotaverine
7 - 12 hours
Side Effects of Drotaverine
1.Hypotension
2.Headache
3.Tachycardia
4.Nausea
5.Vertigo
Contra-indications of Drotaverine
1.Hypersensitivity to Drotaverine
2.Severe renal impairment
3.Severe hepatic impairment
4.Severe cardiac impairment
Special Precautions while taking Drotaverine
1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Drotaverine
1.Smooth muscle spasm
2.Gastrointestinal colic pain
3.Renal colic pain
4.Dysmenorrhoea
5.Uterine neck spasm
6.Post MTP(Medical termination of pregnancy)
7.Post D&C(Dilatation and curettage)
8.Post surgical spasm
9.Irritable bowel syndrome
Interactions for Drotaverine
N/A
Typical Dosage for Drotaverine
Adult:
Oral: 120 - 240 mg / day in 3 divided doses.
Children: 60 - 120 mg / day in 3 divided doses, dose is depending upon the age of the patient.
Parenteral (IM)
Induction of labour: 40 mg every 2 hours, maximum 3 doses.

Schedule of Drotaverine
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Storage Requirements for Drotaverine
Store in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of Drotaverine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Drotaverine
Give supportive measures and symptomatic treatment.

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Home Delivery for Drotaverine + Paracetamol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for drotaverine + paracetamol and other medicines and health products. Home delivery services for drotaverine + paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take drotaverine + paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for drotaverine + paracetamol before they complete the sale. You can get this information while placing the order for drotaverine + paracetamol with the pharmacy.

Drotaverine + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for drotaverine + paracetamol might be better known than drotaverine + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have drotaverine + paracetamol in stock, you can ask for one of the branded alternatives for drotaverine + paracetamol.