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- Pharmacology For Lornoxicam +Paracetamol
Lornoxicam +Paracetamol Pharmacology
Lornoxicam +Paracetamol
About Lornoxicam +ParacetamolN/AMechanism of Action of Lornoxicam +ParacetamolN/APharmacokinets of Lornoxicam +ParacetamolN/AOnset of Action for Lornoxicam +ParacetamolN/ADuration of Action for Lornoxicam +ParacetamolN/AHalf Life of Lornoxicam +ParacetamolN/ASide Effects of Lornoxicam +ParacetamolN/AContra-indications of Lornoxicam +ParacetamolN/ASpecial Precautions while taking Lornoxicam +ParacetamolN/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContra indicatedChildren Related InformationNot recommendedIndications for Lornoxicam +ParacetamolTreatment of musculoskeletal pain and inflammation.Interactions for Lornoxicam +ParacetamolN/ATypical Dosage for Lornoxicam +ParacetamolN/ASchedule of Lornoxicam +ParacetamolN/AStorage Requirements for Lornoxicam +ParacetamolN/AEffects of Missed Dosage of Lornoxicam +ParacetamolN/AEffects of Overdose of Lornoxicam +ParacetamolN/ALornoxicam
About LornoxicamNon-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. It is available in oral and parenteral formulations.Mechanism of Action of LornoxicamLike other NSAIDs, lornoxicam inhibits prostaglandin biosynthesis by blocking the enzyme cyclooxygenase. Lornoxicam inhibits both isoforms in the same concentration range, that is, the ratio of COX-1 inhibition to COX-2 inhibition is 1:1. It readily penetrates into the synovial fluid.Pharmacokinets of LornoxicamAbsorption:well absorbed oraly,food delays absorption
Distribution: 99% bound to plasma proteins.
Metabolism: Metabolised to its inactive metabolite
Elimination:Approximately 1/2 to 2/3 is eliminated via the liver and 1/3 to 42% via the
kidneys as 5?-hydroxylornoxicam.
Onset of Action for LornoxicamN/ADuration of Action for LornoxicamN/AHalf Life of Lornoxicam3-4 hr.Side Effects of Lornoxicam1.Gastrointestinal disorders (nausea and diarrhea)
2.Headache.
3.Severe but seldom side effects include bleeding, bronchospasms and the extremely rare stevens?johnson syndrome
Contra-indications of Lornoxicam1.Salicylate sensitivity
2.Gastrointestinal bleeding and bleeding disorders
3.Severe impairment of heart, liver or kidney function
Special Precautions while taking Lornoxicam1.Active infections
2.Asthma
3.Allergic disorders
4.Haemorrhagic disorders
5.Hypertension
6.Impaired renal, hepatic, cardiac function.
7.Lornoxicam should be taken with a meal to minimise gastrointestinal irritation.
Pregnancy Related InformationCotra indicatedOld Age Related InformationReduce the doseBreast Feeding Related InformationCotra indicatedChildren Related InformationDo not use lornoxicam in children under the age of 18Indications for LornoxicamTreatment of various types of pain, especially resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica, and other inflammations.Interactions for Lornoxicam1.Vitamin K antagonists like warfarin increases the risk of bleeding.
2.Ciclosporin can lead to reduced kidney function, and to acute renal failure in rare cases.
3.Lornoxicam can also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives.
4.The effect of diuretics, ACE inhibitors and angiotensin II receptor antagonists can be reduced, but this is only relevant in patients with special risks like heart failure.
5.Piroxicam, cimetidine can increase plasma levels
Typical Dosage for Lornoxicam1.Pain relief:Adult: 8-16 mg daily. Max: 24 mg daily. (Oral)
2.Osteoarthritis:Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.(Oral)
3.Rheumatoid arthritis:Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.Parenteral
4.Pain relief:Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.
Schedule of LornoxicamSchedule HStorage Requirements for LornoxicamN/AEffects of Missed Dosage of LornoxicamN/AEffects of Overdose of LornoxicamA small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Lornoxicam +Paracetamol in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lornoxicam +paracetamol and other medicines and health products. Home delivery services for lornoxicam +paracetamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take lornoxicam +paracetamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lornoxicam +paracetamol before they complete the sale. You can get this information while placing the order for lornoxicam +paracetamol with the pharmacy.
Lornoxicam +Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for lornoxicam +paracetamol might be better known than lornoxicam +paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lornoxicam +paracetamol in stock, you can ask for one of the branded alternatives for lornoxicam +paracetamol.
