Indacaterol Maleate Pharmacology

Indacaterol Maleate

About Indacaterol Maleate
Ultra-Long-Acting Beta-Adrenoceptor Agonist.
Mechanism of Action of Indacaterol Maleate
Indacaterol is a long-acting ?2-adrenoceptor agonist, that relaxes bronchial smooth muscles,which is used for the maintenance treatment of airflow obstruction in adult patients with chronic obstructive pulmonary disease (COPD),such as such as wheezing and breathlessness.Indacaterol has a 24-hour bronchodilatory effect, which allows for once-daily administration.
Pharmacokinets of Indacaterol Maleate
Absorption:T max is approximately 15 min. Absolute bioavailability after an inhaled dose is 43% to
45%.

Distribution:Volume of distribution is 2,361 to 2,557 L. Plasma protein binding is 95.1% to 96.2%.

Metabolism:Metabolized by UGT1A1 to a phenolic O-glucuronide and to a hydroxylated derivative
by CYP3A4.

Elimination:Less than 2% excreted unchanged in the urine; 54% excreted unchanged in the feces.
Onset of Action for Indacaterol Maleate
N/A
Duration of Action for Indacaterol Maleate
N/A
Half Life of Indacaterol Maleate
40 to 56 h
Side Effects of Indacaterol Maleate
1.Runny nose
2.Cough
3.Sore throat
4.Headache
5.Nause
6.Increased Heart Rate
7.Palpitations
8.Tachycardia
Contra-indications of Indacaterol Maleate
Asthma
Special Precautions while taking Indacaterol Maleate
1.It is not intended for acute relief of COPD exacerbation.
2.Risk for asthma-related death may be increased.
3.Use with caution in patients with convulsive disorders or thyrotoxicosis, and in patients unusually responsive to sympathomimetic amines.
Pregnancy Related Information
Contra indicated
Old Age Related Information
No dosage adjustmet needed
Breast Feeding Related Information
Use with caution
Children Related Information
Not recommended
Indications for Indacaterol Maleate
Indacaterol treats the symptoms of chronic obstructive pulmonary disease (COPD).
Interactions for Indacaterol Maleate
1.Sympathetic effects of indacaterol may be potentiated by Adrenergic drugs .
2.Beta-2 agonists:Indacaterol should not be used with other long-acting beta-2 agonists. An overdose may result
3.Beta-blockers:Beta-blockers and indacaterol may interfere with each other's effects.
4.Corticosteroids,xanthine derivatives:Concomitant treatment with these agents may potentiate any hypokalemic effect of indacaterol. Use with caution and monitor serum potassium concentrations.
5.Concomitant treatment with non?potassium-sparing diuretics (eg, loop diuretics, thiazide diuretics) may potentiate any hypokalemic effect of indacaterol.
6.MAOIs,QT prolonging drugs,tricyclic antidepressants:Indacaterol should be administered with extreme caution to patients being treated with these agents because the action of indacaterol on the CV system may be potentiated.
Typical Dosage for Indacaterol Maleate
Adults :Oral inhalation 75 mcg once daily at the same time of day.
Schedule of Indacaterol Maleate
N/A
Storage Requirements for Indacaterol Maleate
Store in a dry place, between 59? and 86?F. Protect from light and moisture. Store capsules in the blister and only remove immediately before use.

Effects of Missed Dosage of Indacaterol Maleate
N/A
Effects of Overdose of Indacaterol Maleate
Symptoms:Angina, arrhythmias, cardiac arrest, death, dizziness, dry mouth, fatigue, headache, hyperglycemia, hypertension, hypokalemia, hypotension, insomnia, malaise, metabolic acidosis, muscle cramps, nausea, nervousness, palpitation, tachycardia, tremor.
Get immediate medical attention

Home Delivery for Indacaterol Maleate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for indacaterol maleate and other medicines and health products. Home delivery services for indacaterol maleate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take indacaterol maleate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for indacaterol maleate before they complete the sale. You can get this information while placing the order for indacaterol maleate with the pharmacy.

Indacaterol Maleate is a generic medicine name and there are several brands available for it. Some of the brands for indacaterol maleate might be better known than indacaterol maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have indacaterol maleate in stock, you can ask for one of the branded alternatives for indacaterol maleate.