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- Pharmacology For Citicoline + Piracetam
Citicoline + Piracetam Pharmacology
Citicoline + PiracetamAbout Citicoline + PiracetamN/AMechanism of Action of Citicoline + PiracetamN/APharmacokinets of Citicoline + PiracetamN/AOnset of Action for Citicoline + PiracetamN/ADuration of Action for Citicoline + PiracetamN/AHalf Life of Citicoline + PiracetamN/ASide Effects of Citicoline + PiracetamN/AContra-indications of Citicoline + PiracetamN/ASpecial Precautions while taking Citicoline + PiracetamN/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContra indicatedChildren Related InformationSafety not establishedIndications for Citicoline + Piracetam1.Head injury
4.As a cognitive enhancer
Interactions for Citicoline + PiracetamN/ATypical Dosage for Citicoline + PiracetamN/ASchedule of Citicoline + PiracetamN/AStorage Requirements for Citicoline + PiracetamN/AEffects of Missed Dosage of Citicoline + PiracetamN/AEffects of Overdose of Citicoline + PiracetamN/A
CiticolineAbout CiticolineNootropics,Cerebrovascular insult and insufficiancyMechanism of Action of CiticolineCiticoline increases blood flow and O2 consumption in the brain. It is also involved in the biosynthesis of lecithin.Citicoline enhance the synthesis of phosphatidyl-choline in brain but could inhibit destructive process(activation of phospholipases)Pharmacokinets of CiticolineAbsorption: Absorbed after oral administration
Distribution: Widely distributed in the body,cross the blood brain barrier
Metabolism: Metabolised in the liver
Excretion: Excreted through urine
Onset of Action for CiticolineN/ADuration of Action for CiticolineN/AHalf Life of Citicoline24 hrsSide Effects of Citicoline1.Insomnia
4.High or low blood pressure
Contra-indications of CiticolineHypersensitivity to drugSpecial Precautions while taking Citicoline1.Hepatic problem
3.Acute, severe & progressive disturbance of consciousness
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationN/AChildren Related InformationUse with cautionIndications for Citicoline1.Parkinson?s disease
3.Cerebral vascular disease
5.Cerebral surgery or acute cerebral disturbance
6.Disturbance of consciousness following brain surgery
Interactions for CiticolineLevo Dopa: Increases the effect of levodopaTypical Dosage for CiticolineCerebrovascular disorders and head injury:
Oral: Adult: 200-600 mg daily in divided doses
Parenteral: Up to 1 g IM/IV daily
Oral: 200-600 mg daily in divided doses
Parenteral: Up to 1 g IM/IV daily
Schedule of CiticolineHStorage Requirements for CiticolineStore in a tightly closed container,below 25 dgree C. Keep out of the reach of childrenEffects of Missed Dosage of CiticolineN/AEffects of Overdose of CiticolineN/A
PiracetamAbout PiracetamPyrrolidone derivative, a cyclic derivative of GABA, Nootropic,in cerebrovascular insults and insufficiency.Mechanism of Action of PiracetamPiracetam is a cyclic GABA derivative. It facilitates the movement of information between the brain`s 2 hemispheres via corpus callosum and improves the function of Acetylcholine via muscarinic receptors which are implicated in memory process. Piracetam is also called as Nootropics or cognition enhancer.
Piracetam improves the production of adenosine triphosphate (ATP) which is the energy storage and energy generating molecules within our cells. Piracetam increases the blood flow to the brain and promote cerebral metabolism. It increases brain`s use of glucose and oxygen. It also enhances protein synthesis in the brain.
Piracetam enhances the excitatory neurotransmitter NMDA glutamate receptor which is involved in learning and memory process.
Piracetam modulates calcium and potassium ion channels.
Pharmacokinets of PiracetamAbsorption: It is well absorbed after oral administration.
Excretion: It is excreted mainly through urine.
Onset of Action for Piracetam30 - 60 minutesDuration of Action for Piracetam1 dayHalf Life of Piracetam4 - 5 hoursSide Effects of Piracetam1. Nausea
2. Epigastric distress
3. Skin rash
8. Sleep disturbances
13. Weight gain
Contra-indications of PiracetamN/ASpecial Precautions while taking Piracetam1. Hepatic impairment
2. Renal impairment
3. Cardiac impairment
4. Slowly withdraw the drug with caution
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES : ContraindicatedIndications for Piracetam1. Mental retardation and Dyslexia in children
2. Senile dementia and confusional states of old age
3. Cerebrovascular accidents
4. To reduce impairment of consciousness following brain surgery
Interactions for PiracetamOral anticoagulants: Increased prothrombin time.Typical Dosage for PiracetamAdults: Ischemic stroke: 12gm I.V./20 minutes, followed by 12gm I.V./day for 4 weeks or orally.
Post-stroke complications (aphasia/hemiplegia): 4.8gm/day for 8 weeks.
Age associated problems (memory lapses, vertigo, concentration gap): 2.4-4.8 gm/day for 12 weeks
Learning difficulties: 3 gm/day in 3 divided doses for 1 school year.
Children: 50 mg/kg body weight in 3 separate doses. Once the desired result has been obtained reduce the initial dose by half upto 6-8 weeks.Schedule of PiracetamHStorage Requirements for PiracetamStore below 25 degree C in tightly closed container moisture. Protect from moisture. Keep out of the reach of children.Effects of Missed Dosage of PiracetamTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and take that dose. Do not double the dose. Continue the regular schedule.Effects of Overdose of PiracetamGive supportive measures and symptomatic treatment. Drug can be removed from the body by forced diuresis. In renal insufficiency drug can be removed by dialysis.
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