Penicillin G Benzathine Pharmacology

Penicillin G Benzathine

About Penicillin G Benzathine
A long-acting depot form of benzathine salt of natural penicillin, A narrow spectrum antibiotic.
Mechanism of Action of Penicillin G Benzathine
Penicillin G Benzathine is one of the members of beta lactum antibiotics. It is a bactericidal drug. It binds to the penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. This is more active against gram positive organism than gram negative organism.
Pharmacokinets of Penicillin G Benzathine
Absorption: It is very slowly absorbed from intramuscular injection site.Distribution: It is distributed through out the body.Metabolism: It is metabolized to penicillin G initially and then to inactive metabolite.Excretion: It is excreted via urine.
Onset of Action for Penicillin G Benzathine
Duration of Action for Penicillin G Benzathine
14-28 days
Half Life of Penicillin G Benzathine
Side Effects of Penicillin G Benzathine
1. Local pain
2. Rash
3. Thrombophlebitis
4. Jarisch Herxheimer reaction
5. Anaphylaxis
6. Mental disturbances
7. Haemolytic anemia
Contra-indications of Penicillin G Benzathine
Hypersensitive to Penicillin G Benzathine and other Penicillins
Special Precautions while taking Penicillin G Benzathine
1.Renal impairment
2.Allergic to other penicillins

Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Penicillin G Benzathine
3.Rheumatic fever
4.Otitis media
9.Scarlet fever
Interactions for Penicillin G Benzathine
Aminoglycosides, parenteral : Certain parenteral penicillins may inactivate certain aminoglycosides in vitro - do not mix in the same I.V. solution.
Anticoagulants : Large I.V. doses of penicillins prolong bleeding time - chances of bleeding.
Oral contraceptives : Efficacy of oral contraceptives reduced. Additional form of contraception during penicillin therapy is advisable.
Heparin : With parenteral penicillins there is increased risk of bleeding.
Erythromycin : Both synergism and antagonism have been reported.
Allopurinol : Rate of ampicillin-induced skin rash appears much higher when co-administered with allopurinol.
Tetracyclines : Bacteriostatic effects of tetracycline derivatives may impair bactericidal effects of penicillins.
Probenecid : Prolongs half-life of penicillin.

Typical Dosage for Penicillin G Benzathine
12lac - 24lac units IM as a single dose
Primary and secondary syphilis: 24lac units once daily; Tertiary and late syphilis: 24 lac units once weekly for 3 weeks
Prophylaxis of rheumatic fever: 600000 units every 2 week
General dose: 3lac-12lac units as a single dose
Congenital syphilis: 500000units/kg IM as single dose.
Schedule of Penicillin G Benzathine
Storage Requirements for Penicillin G Benzathine
Store at cold temperature.Do not freeze. Keep out of the reach of children.
Effects of Missed Dosage of Penicillin G Benzathine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Penicillin G Benzathine
Give supportive measures and treatment. If necessary haemodialysis can be done

Home Delivery for Penicillin G Benzathine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including penicillin g benzathine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for penicillin g benzathine and other medicines and health products. Home delivery services for penicillin g benzathine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take penicillin g benzathine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for penicillin g benzathine before they complete the sale. You can get this information while placing the order for penicillin g benzathine with the pharmacy.

Penicillin G Benzathine is a generic medicine name and there are several brands available for it. Some of the brands for penicillin g benzathine might be better known than penicillin g benzathine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have penicillin g benzathine in stock, you can ask for one of the branded alternatives for penicillin g benzathine.