Dicloxacillin + Cefixime Pharmacology

Dicloxacillin + Cefixime

About Dicloxacillin + Cefixime
N/A
Mechanism of Action of Dicloxacillin + Cefixime
N/A
Pharmacokinets of Dicloxacillin + Cefixime
N/A
Onset of Action for Dicloxacillin + Cefixime
N/A
Duration of Action for Dicloxacillin + Cefixime
N/A
Half Life of Dicloxacillin + Cefixime
N/A
Side Effects of Dicloxacillin + Cefixime
1.Nausea
2.Drowsiness
3.Skin rash
4.Diarrhea.
Contra-indications of Dicloxacillin + Cefixime
N/A
Special Precautions while taking Dicloxacillin + Cefixime
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Dicloxacillin + Cefixime
To treat various types of infections.
Interactions for Dicloxacillin + Cefixime
N/A
Typical Dosage for Dicloxacillin + Cefixime
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Schedule of Dicloxacillin + Cefixime
N/A
Storage Requirements for Dicloxacillin + Cefixime
N/A
Effects of Missed Dosage of Dicloxacillin + Cefixime
N/A
Effects of Overdose of Dicloxacillin + Cefixime
N/A

Dicloxacillin

About Dicloxacillin
A semisynthetic narrow spectrum beta-lactam antibiotic ofpenicillin class, Penicillinase resistant Antibiotic.
Mechanism of Action of Dicloxacillin
Like other ?-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.
Pharmacokinets of Dicloxacillin
Absorption :Absorption after oral administration is rapid but incomplete,food delays absorption
Distribution: widespread, highest in kidneys & liver, CSF low
Protein Binding: 96%
Metabolism: hepatic CYP3A4
Excretion: renal, feces
Onset of Action for Dicloxacillin
N/A
Duration of Action for Dicloxacillin
N/A
Half Life of Dicloxacillin
0.7 hour
Side Effects of Dicloxacillin
1.Diarrhoea
2.Nausea
3.Rash
4.Urticaria
5.Pain and inflammation at injection site
6.Superinfection (including candidiasis)
7.Allergy
8.Transient increases in liver enzymes and bilirubin
Contra-indications of Dicloxacillin
1.Hypersensitivity to penicillins,cephalosporins, carbapenems
2.Not to be used in the eye
3.Cholestatic hepatitis associated with the use of dicloxacillin
Special Precautions while taking Dicloxacillin
1.Renal impairment
2.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Excreted in breast milk, use caution
Children Related Information
N/A
Indications for Dicloxacillin
1.Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
2.Staphylococcal skin infections and cellulitis ? including impetigo, otitis externa, folliculitis, boils, carbuncles, and mastitis
3.Pneumonia (adjunct)
4.Osteomyelitis, septic arthritis, throat infections, streptococcus
5.Septicaemia
6.Empirical treatment for endocarditis
7.Surgical prophylaxis
Interactions for Dicloxacillin
1.Dicloxacillin decreases anticoagulant effect of warfarin
2.Probenecid prolongs T1/2 of dicloxacillin
3.Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Typical Dosage for Dicloxacillin
Adult:250 to 500mg in every 6 hours
Paediatric:<40 kg: 12.5-25 mg/kg/day PO divided q6hr
Schedule of Dicloxacillin
N/A
Storage Requirements for Dicloxacillin
N/A
Effects of Missed Dosage of Dicloxacillin
N/A
Effects of Overdose of Dicloxacillin
N/A

Cefixime

About Cefixime
Third Generation Cephalosporin Oral antibiotic
Mechanism of Action of Cefixime
Cefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.
Pharmacokinets of Cefixime
Absorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urine
Onset of Action for Cefixime
Within one hour
Duration of Action for Cefixime
18 hours
Half Life of Cefixime
3 hour
Side Effects of Cefixime
1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime
1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime
1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Above 6 months: may be used
Neonates: contraindicated
Indications for Cefixime
1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for Cefixime
Probenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.
Typical Dosage for Cefixime
Adults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of Cefixime
H
Storage Requirements for Cefixime
N/A
Effects of Missed Dosage of Cefixime
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefixime
Adopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis

Home Delivery for Dicloxacillin + Cefixime in Your City

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Dicloxacillin + Cefixime is a generic medicine name and there are several brands available for it. Some of the brands for dicloxacillin + cefixime might be better known than dicloxacillin + cefixime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicloxacillin + cefixime in stock, you can ask for one of the branded alternatives for dicloxacillin + cefixime.