Penicillin V Pharmacology

Penicillin V

About Penicillin V
Semisynthetic ?-lactamase resistant penicillin, Antibiotic.
Mechanism of Action of Penicillin V
Penicillin V is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Penicillin is more active against gram positive organism than gram negative organism.

Pharmacokinets of Penicillin V
Absorption: It is well absorbed .Distribution: It is widely distributed all over the body.Metabolism: It is metabolized to inactive compound.Excretion: It is excreted mainly through urine
Onset of Action for Penicillin V
Duration of Action for Penicillin V
Half Life of Penicillin V
30 minutes
Side Effects of Penicillin V
8.Haemolytic anemia

Contra-indications of Penicillin V
1.Hyper sensitivity to penicillin V and other Penicillins
Special Precautions while taking Penicillin V
1.Renal impairment
2.Patients having history of allergy

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Penicillin V
1. Otitis media
2. Tonsilitis
3. Endocarditis
4. Pneumonia
5. Gingivitis
6. Rheumatic fever
7. Erysipelas
Interactions for Penicillin V
Aminoglycosides, parenteral : Certain parenteral penicillins may inactivate certain aminoglycosides in vitro - do not mix in the same I.V. solution.
Anticoagulants : Large I.V. doses of penicillins prolong bleeding time - chances of bleeding.
Oral contraceptives : Efficacy of oral contraceptives reduced. Additional form of contraception during penicillin therapy is advisable.
Heparin : With parenteral penicillins there is increased risk of bleeding.
Erythromycin : Both synergism and antagonism have been reported.
Allopurinol : Rate of ampicillin - induced skin rash appears much higher when co-administered with allopurinol.
Tetracyclines : Bacteriostatic effects of tetracycline derivatives may impair bactericidal effects of penicillins.
Probenecid : Prolongs half-life of penicillin.

Typical Dosage for Penicillin V
General oral dose: 0.5- 2 g daily in 4 divided doses depending on the severity of infection
Gingivitis: 250-500 mg in 3 or 4 times daily
Pneumococcal infections: 250 mg 2 times daily
15-60 mg/kg daily in 3-4 divided doses depending on the severity of infection
Pneumococcal infections: 250 mg in two divided doses
Schedule of Penicillin V
Storage Requirements for Penicillin V
Store the drug at room temperature. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Penicillin V
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose and continue the regular dose
Effects of Overdose of Penicillin V
Give supportive measures. The absorption of drug can be reduced by gastric lavage or induction of emesis followed by administration of charcoal.

Home Delivery for Penicillin V in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including penicillin v.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for penicillin v and other medicines and health products. Home delivery services for penicillin v may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take penicillin v only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for penicillin v before they complete the sale. You can get this information while placing the order for penicillin v with the pharmacy.

Penicillin V is a generic medicine name and there are several brands available for it. Some of the brands for penicillin v might be better known than penicillin v itself. If the pharmacy that's willing to deliver medicines to your home doesn't have penicillin v in stock, you can ask for one of the branded alternatives for penicillin v.