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- Pharmacology For Telmisartan + Atorvastatin
Telmisartan + Atorvastatin Pharmacology
Telmisartan + Atorvastatin
About Telmisartan + AtorvastatinN/AMechanism of Action of Telmisartan + AtorvastatinN/APharmacokinets of Telmisartan + AtorvastatinN/AOnset of Action for Telmisartan + AtorvastatinN/ADuration of Action for Telmisartan + AtorvastatinN/AHalf Life of Telmisartan + AtorvastatinN/ASide Effects of Telmisartan + AtorvastatinN/AContra-indications of Telmisartan + AtorvastatinN/ASpecial Precautions while taking Telmisartan + AtorvastatinN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationSafety and efficacy not established.Indications for Telmisartan + Atorvastatin1.Hypertension
2.Also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders.
Interactions for Telmisartan + AtorvastatinN/ATypical Dosage for Telmisartan + AtorvastatinN/ASchedule of Telmisartan + AtorvastatinN/AStorage Requirements for Telmisartan + AtorvastatinN/AEffects of Missed Dosage of Telmisartan + AtorvastatinN/AEffects of Overdose of Telmisartan + AtorvastatinN/ATelmisartan
About TelmisartanAngiotensin II Receptor antagonist, Antihypertensive.Mechanism of Action of TelmisartanIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of TelmisartanAbsorption: Absorbed orally, bioavailability is about 42% Distribution: It is distributed in to the body in a highly protein bound form, Metabolism: Metabolized by glucuronide conjugation in to an inactive metabolite. Excretion: Excreted mainly through faeces and rest is excreted through urine.Onset of Action for TelmisartanN/ADuration of Action for Telmisartan24 hoursHalf Life of Telmisartan24 hoursSide Effects of Telmisartan1.Dizziness
2.Headache
3.Coughing
4.Edema
5.Nausea
6.Abdominal pain
7.Diarrhoea
8.Dyspepsia
9.Pharyngitis
10.Sinusitis
11.Upper respiratory tract infections
12.Urinary tract infections
13.Elevated liver enzymes
14.Weakness
15.Chest pain
16.Myalgia
17.Back pain
18.Neutropenia
19.Fetopathic
20.Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
21.Urticaria
22.Rashes
23.Hyperkalemia
Contra-indications of TelmisartanHypersensitivity to the drugSpecial Precautions while taking Telmisartan1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6.Use cautiously in volume depleted and salt depleted individuals, these conditions should be corrected before starting the therapy
7.Patient should be cautiously involve in driving or operating heavy machinery during therapy
8.Avoid alcohol or use with caution during therapy
9.Use with caution in hyperkalemia and along with potassium sparing diuretics
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Telmisartan1.HypertensionInteractions for TelmisartanN/ATypical Dosage for Telmisartan40mg once daily
Maintenance dose: 20 to 80mg once daily
Schedule of TelmisartanHStorage Requirements for TelmisartanStore at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container. Do not remove blisters until just before taking tablets
Effects of Missed Dosage of TelmisartanTake the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular doseEffects of Overdose of TelmisartanTreatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal salineAtorvastatin
About AtorvastatinHMG-CoA Reductase Inhibitor, statins, Antilipemic agent.Mechanism of Action of AtorvastatinIt is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme; 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL). It causes dose dependent lowering of LDL cholesterol and reduces hepatic synthesis of very low density lipoprotein (VLDL) and lowers plasma triglyceride levels. It also increases high density lipoprotein (HDL) levels. It also exerts antioxidant property.Pharmacokinets of AtorvastatinAbsorption: Readily absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to active metabolite, Excretion: Excreted mainly through bile.Onset of Action for AtorvastatinN/ADuration of Action for AtorvastatinN/AHalf Life of Atorvastatin18 to 24 hoursSide Effects of Atorvastatin1.Headache
2.Dizziness
3.Insomnia
4.Alopecia
5.Anorexia
6.Abdominal discomfort
7.Heart burn
8.Abdominal pain
9.Nausea
10.Dyspepsia
11.Flatulence
12.Constipation
13.Abnormal liver function tests
14.Rash
15.Pruritus
16.Fatigue
17.Myositis
18.Chest pain
19.Impotence
20.Myopathy
21.Upper respiratory tract infections
Contra-indications of Atorvastatin1.Hypersensitivity to the drug
2.Active liver diseases
3.Persistent elevation of serum transaminase levels
Special Precautions while taking Atorvastatin
1.Monitor hepatic function tests and lipid levels before and periodically during therapy and stop drug if there is marked elevation of creatinine phosphokinase level
2.History of liver diseases
3.Alcoholics
4.In severe adverse effects and fever
Pregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 9years: ContraindicatedIndications for Atorvastatin1.Hypercholesterolemia
2.Combined hyperlipidaemia
Interactions for AtorvastatinN/ATypical Dosage for AtorvastatinOral:
Starts with 10mg once daily; Increased if required based on patients response.
Maximum dose: 80mg
Schedule of AtorvastatinHStorage Requirements for AtorvastatinStore at room temperature at a range of 15 to 25 degree C.Effects of Missed Dosage of AtorvastatinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AtorvastatinProvide supportive care and symptomatic treatment.Home Delivery for Telmisartan + Atorvastatin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including telmisartan + atorvastatin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for telmisartan + atorvastatin and other medicines and health products. Home delivery services for telmisartan + atorvastatin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take telmisartan + atorvastatin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for telmisartan + atorvastatin before they complete the sale. You can get this information while placing the order for telmisartan + atorvastatin with the pharmacy.
Telmisartan + Atorvastatin is a generic medicine name and there are several brands available for it. Some of the brands for telmisartan + atorvastatin might be better known than telmisartan + atorvastatin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have telmisartan + atorvastatin in stock, you can ask for one of the branded alternatives for telmisartan + atorvastatin.
