L-Arginine + Sildenafil Citrate Pharmacology
L-Arginine + Sildenafil Citrate
2.Patients concurrently or intermittently using organic nitrates in any form
2.Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur.
3.Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders.
4.May cause sudden loss or decrease in hearing.
8.Worsening of asthma
9.Low blood pressure.
2.Herpes: There is a concern that L-arginine might make herpes worse. There is some evidence that L-arginine is needed for the herpes virus to multiply.
3.Low blood pressure: L-arginine might lower blood pressure. This could be a problem if you already have low blood pressure.
4.Recent heart attack: There is a concern that L-arginine might increase the risk of death after a heart attack, especially in older people. If you have had a heart attack recently, don?t take L-arginine.
5.Surgery: L-arginine might affect blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop taking L-arginine at least 2 weeks before a scheduled surgery.
3.Congestive Heart Failure
2.Medications that increase blood flow to the heart (Nitrates) interacts with L-ARGININE
3.Sildenafil (Viagra) can lower blood pressure. L-arginine can also lower blood pressure
2.For chest pain associated with coronary artery disease (angina pectoris): 3-6 grams three times per day for up to one month.
3.For preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease (angina pectoris): 700 mg four times daily.
4.For organic erectile dysfunction (ED): 5 grams per day. Taking lower doses might not be effective.
5.For preventing inflammation of the digestive tract in premature infants: 261 mg/kg added to oral feedings daily for the first 28 days of life.
Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis and at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis.
Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the corpora cavernosa of the penis. The nitric oxide causes an enzyme guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively, and causing the erection. When the cGMP is destroyed by enzyme phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Sildenafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. It relaxes muscles and increases blood flow to particular areas of the body.
Distribution: It is widely distributed in protein bound form (96% bound to plasma protein) mostly to tissues.
Metabolism: It is metabolized in the liver by an enzyme known as CYP3A4 and others to produce active N-Desmethyl derivatives.
Excretion: It is primarily excreted in the feces (80%) and small amount in the urine
3. Stomach upset
5. Flu-like symptoms
7. Back pain
8. Muscle aches
9. Low blood pressure
10. Blurred vision
11. Abnormal ejaculation
12. Prolonged erections
14. General ill feeling
15. Irregular heartbeat
16. Swelling in hands, ankles, or feet
17. Shortness of breath
In pre-existing heart disease:
1. Chest pain
2. Heart attacks
5. Palpitations and increased heart rate
6. Vision changes
2. Patients on nitrate therapy
3. Patients taking a adrenergic receptor antagonist
2. Contact doctor if erection is painful or lasts longer than 4 hours
3. Heart disease
4. Recent history a heart attack (within the past 90 days)
5. Recent history of stroke or congestive heart failure (within the past 6 months)
9. Liver disease
10. Kidney disease
11. Sickle cell anemia
12. Multiple myeloma
15. Stomach ulcer
16. Retinitis pigmentosa
17. Peyronie`s disease (physical deformity of the penis)
19. High cholesterol
20. Pre-existing eye problems
21. One who smoke or are over 50 years old
Home Delivery for L-Arginine + Sildenafil Citrate in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for l-arginine + sildenafil citrate and other medicines and health products. Home delivery services for l-arginine + sildenafil citrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take l-arginine + sildenafil citrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for l-arginine + sildenafil citrate before they complete the sale. You can get this information while placing the order for l-arginine + sildenafil citrate with the pharmacy.
L-Arginine + Sildenafil Citrate is a generic medicine name and there are several brands available for it. Some of the brands for l-arginine + sildenafil citrate might be better known than l-arginine + sildenafil citrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have l-arginine + sildenafil citrate in stock, you can ask for one of the branded alternatives for l-arginine + sildenafil citrate.