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- Pharmacology For Lactitol + Ispaghula Husk
Lactitol + Ispaghula Husk Pharmacology
Lactitol + Ispaghula HuskAbout Lactitol + Ispaghula HuskN/AMechanism of Action of Lactitol + Ispaghula HuskN/APharmacokinets of Lactitol + Ispaghula HuskN/AOnset of Action for Lactitol + Ispaghula HuskN/ADuration of Action for Lactitol + Ispaghula HuskN/AHalf Life of Lactitol + Ispaghula HuskN/ASide Effects of Lactitol + Ispaghula HuskN/AContra-indications of Lactitol + Ispaghula HuskN/ASpecial Precautions while taking Lactitol + Ispaghula HuskShould not be swallowed dry, dehydration intestinal structure.Pregnancy Related InformationContra indicated especially in first trimesterOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Lactitol + Ispaghula Husk10 mg lactitol monohydrate in combination with 3.5 g powdered Ispaghula husk is an approved combination for Idiopathic constipation as a laxative and is used to prevent or treat constipation.Interactions for Lactitol + Ispaghula HuskN/ATypical Dosage for Lactitol + Ispaghula HuskN/ASchedule of Lactitol + Ispaghula HuskN/AStorage Requirements for Lactitol + Ispaghula HuskN/AEffects of Missed Dosage of Lactitol + Ispaghula HuskN/AEffects of Overdose of Lactitol + Ispaghula HuskN/A
LactitolAbout LactitolIt is an Osmotic laxative.Mechanism of Action of LactitolIn the colon it is broken down to short chain organic acids and acidify,this results in an increase in osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume which explains the laxative effect.Pharmacokinets of LactitolAbsorption: Lactitol is not significantly absorbed in the small intestine; only 0.5% to 2% of a dose is
partially absorbed as unchanged lactitol
Metabolism: Absorbed volatile fatty acids are either metabolized in the colon
Excretion: 6.5% excreted in the feces. Small amounts of unchanged lactitol appear in the urine (2% or less of a dose).
Onset of Action for Lactitol24 to 48 hrsDuration of Action for LactitolN/AHalf Life of LactitolN/ASide Effects of Lactitol1. Rectal irritation
2. Dangerous potassium loss.
5. RashContra-indications of Lactitol1.Appendicitis
2.Abdominal pain or bleeding
3.Hypersensitivity to the drug
Special Precautions while taking Lactitol1. Gastro intestinal problem
2. Cardio vascular problemPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Lactitol1.Constipation relief
3.Prevention of hepatic encephalopathy.
Interactions for Lactitol1. Antacids tablet coating may dissolve too rapidly, irritating stomach or bowel.
2. Antihypertensives may cause dangerous low potassium level.
3. Diureticsm may cause dangerous low potassium level. Typical Dosage for LactitolAdults: 15 to 30 mL (10 to 20 g lactulose) daily; may increase to 60 mL/day.
Older Children and Adolescents: 40 to 90 mL/day in divided doses to produce 2 to 3 soft stools/day
Infants: 2.5 to 10 mL/day in divided doses to produce 2 to 3 soft stools/day
Schedule of LactitolHStorage Requirements for LactitolStore at room temperature (below 86?F). Do not freeze.Effects of Missed Dosage of LactitolN/AEffects of Overdose of LactitolN/A
Ispaghula HuskAbout Ispaghula HuskBulk forming agent, LaxativeMechanism of Action of Ispaghula HuskAbsorbs water in the GI tract to form a mucilaginous mass which increases the volume of faeces and hence promotes peristalsisPharmacokinets of Ispaghula HuskAbsorption: Absorbed after oral administration
Metabolism: Metabolised in the colon
Onset of Action for Ispaghula HuskN/ADuration of Action for Ispaghula HuskN/AHalf Life of Ispaghula HuskN/ASide Effects of Ispaghula Husk1.Hypersensitivity reactions
2.Temporary increase of flatulence and abdominal distension
Contra-indications of Ispaghula Husk1.Intestinal obstruction
Special Precautions while taking Ispaghula Husk1.Intestinal or oesophageal obstruction
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ispaghula Husk1.Constipation
3.Mild to moderate hypercholesterolaemia
Interactions for Ispaghula HuskMay delay or reduce GI absorption of the cardiac glycosides, coumarin derivatives, lithium, vitamin (e.g. vitamin B12) and minerals (e.g. calcium, iron or zinc), carbamazepineTypical Dosage for Ispaghula HuskConstipation: 3.5 g, taken 1-3 times daily. To be taken immediately after mixing in 150 ml of water or fruit juice
Haemorrhoids: 3.5 g, taken 1-3 times daily. To be taken immediately after mixing in 150 ml of water or fruit juice
Mild to moderate hypercholesterolaemia: As an adjunct to lipid-lowering diet: 7 g daily
Schedule of Ispaghula HuskN/AStorage Requirements for Ispaghula HuskStore below 40 degree celcius in a well closed container. Protect from sunlight and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Ispaghula HuskN/AEffects of Overdose of Ispaghula HuskN/A
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