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- Pharmacology For Codeine + Triprolidine
Codeine + Triprolidine Pharmacology
Codeine + Triprolidine
About Codeine + TriprolidineN/AMechanism of Action of Codeine + TriprolidineN/APharmacokinets of Codeine + TriprolidineN/AOnset of Action for Codeine + TriprolidineN/ADuration of Action for Codeine + TriprolidineN/AHalf Life of Codeine + TriprolidineN/ASide Effects of Codeine + TriprolidineN/AContra-indications of Codeine + TriprolidineN/ASpecial Precautions while taking Codeine + TriprolidineN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Codeine + Triprolidine1.Dry cough
2.Allergic cough
Interactions for Codeine + TriprolidineN/ATypical Dosage for Codeine + TriprolidineN/ASchedule of Codeine + TriprolidineN/AStorage Requirements for Codeine + TriprolidineN/AEffects of Missed Dosage of Codeine + TriprolidineN/AEffects of Overdose of Codeine + TriprolidineN/ACodeine
About CodeineAn opiate, methylmorphine , Narcotic analgesic, antitussive, and antidiarrheal.Mechanism of Action of CodeineCodeine exerts it`s action through opioid receptors and posses antitussive properties. It selectively and directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptors.Pharmacokinets of CodeineAbsorption: Well absorbed after oral and parenteral administration. Distribution: Widely distributed in the body; it crosses placenta and also enters in to the breast milk. Metabolism: Metabolized in the liver by demethylation and glucuronide conjugation, Excretion: Excreted mainly in the urine as nor codeine and free and conjugated morphine.Onset of Action for CodeineOral: 30 to 45 minutes
I.V.: Rapid
I.M.: 10 to 30 minutes
S.C.: 10 to 30 minutes
Duration of Action for CodeineOral: 4 to 6 hours
I.V.: 4 to 6 hours
I.M.: 4 to 6 hours
S.C.: 4 to 6 hours
Half Life of CodeineN/ASide Effects of Codeine1. Constipation
2. Nausea
3. Vomiting
4. Drymouth
5. Respiratory depression
6. Hypotension
7. Bradycardia
8. Dizziness
9. Sedation
10. Euphoria
11. Urine retention
12. Flushing
13. Pruritus
14. Diaphoresis
15. Physical dependence.Contra-indications of Codeine1. Hypersensitivity to the drug
2. Bronchial asthma
3. Increased intracranial pressure
4. Respiratory depression
5. Paralytic ileus
6. Head injury
7. Alcoholism
8. Diverticulitis
9. Following bowel surgery.Special Precautions while taking Codeine1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
4. Hypothyroidism
5. Addison`s disease
6. COPD
7. In deliberate individuals
8. Prostatic hypertrophy
9. Epilepsy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Codeine1. Nonproductive cough
2. Mild to moderate pain.Interactions for CodeineN/ATypical Dosage for CodeineAdults:
Oral:
Nonproductive cough:10 to 20mg 4 times daily;Maximum dose: 120mg/day
Oral, S.C., I.M.:
Mild to moderate pain:15 to 60mg Orally, S.C., or I.M.;4 to 6 times daily as required by the patient.
Children:
Oral:
Nonproductive cough:
Over 12 years: 10 to 20mg 4 times daily
Age 6 to 12: 5 to 10mg 4 times daily;Maximum dose: 60mg/day
Age 2 to 6: 1mg/kg/day as four equally divided doses and do not exceed 30mg in 24 hours.
Oral, S.C., I.M.:
Mild to moderate pain:0.5mg/kg orally every 4 to 6 hours or 0.5mg/kg S.C. or I.M.
Schedule of CodeineHStorage Requirements for CodeineStore at controlled room temperature at a range of 15 to 30 degree C and protects from light.Effects of Missed Dosage of CodeineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CodeineEstablish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.Triprolidine
About TriprolidineFirst generation histamine H1 antagonist, Alkylamine derivative, Antihistamine.Mechanism of Action of TriprolidineTriprolidine hydrochloride exerts it`s action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions
Pharmacokinets of TriprolidinePharmacokinetics: Absorption: Well absorbed orally, Distribution: Widely distributed in the body, Metabolism: Metabolized in the body by carboxylation in to metabolites,
Excretion: Excreted through urine.Onset of Action for TriprolidineN/ADuration of Action for TriprolidineN/AHalf Life of TriprolidineN/ASide Effects of Triprolidine1. Sedation
2. Inability to concentrate
3. Diminished alertness
4. Motor incordination
5. Fatigue
6. Insomnia
7. Somnolence
8. Dry mouth
9. Urinery hesitancy
10. Alterd bowel movement
11. Orthostatic hypotension
12. Palpitations
13. Tachycardia
14. Drowsiness
15. Dizziness
16. Excitation
17. Headache
18. Nervousness
19. Blurred vision
20. Nasal stuffiness
21. Anorexia
22. Epigastric distress
23. Nausea
24. Vomiting
25. Diarrhea
26. Constipation
27. Thickening of bronchial secretions
Contra-indications of Triprolidine1. Hypersensitivity to the drug
2. Coronary insufficiency
3. Hypertension
4. Prostatism
5. Thyrotoxicosis
6. Bladder dysfunction
7. Narrow angle glaucoma
8. Phaeochromocytoma
9. Asthma
Special Precautions while taking Triprolidine1. Driving or any work requiring mental alertness
2. Peptic ulcer
3. Pyloroduodenal obstruction
4. Prostatic hypertrophy
5. Bladder neck obstruction
6. Urinary retention
7. Increased intraocular pressure
8. Hyperthyroidism
9. Sleep apnea
10. Cardiovascular disease
11. Along with other medication
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Triprolidine1. Common cold
2. Allergic respiratory diseases
3. Runny nose
4. Sneezing
5. Itchy nose and throat
6. Itchy,watery eyes
7. Cough
Interactions for TriprolidineN/ATypical Dosage for TriprolidineOral: 2.5 to 5mg dosage forms are availableSchedule of TriprolidineGStorage Requirements for TriprolidineStore at room temperature at a range of 15 to 30 degree C. Protect from light, heat, and moisture.Effects of Missed Dosage of TriprolidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TriprolidineProvide symptomatic treatment and supportive measures. Home Delivery for Codeine + Triprolidine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including codeine + triprolidine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for codeine + triprolidine and other medicines and health products. Home delivery services for codeine + triprolidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take codeine + triprolidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for codeine + triprolidine before they complete the sale. You can get this information while placing the order for codeine + triprolidine with the pharmacy.
Codeine + Triprolidine is a generic medicine name and there are several brands available for it. Some of the brands for codeine + triprolidine might be better known than codeine + triprolidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have codeine + triprolidine in stock, you can ask for one of the branded alternatives for codeine + triprolidine.
