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- Pharmacology For Rabeprazole + Itopride
Rabeprazole + Itopride Pharmacology
Rabeprazole + Itopride
About Rabeprazole + ItoprideN/AMechanism of Action of Rabeprazole + ItoprideN/APharmacokinets of Rabeprazole + ItoprideN/AOnset of Action for Rabeprazole + ItoprideN/ADuration of Action for Rabeprazole + ItoprideN/AHalf Life of Rabeprazole + ItoprideN/ASide Effects of Rabeprazole + Itopride1.Headache
2.Diarrhea
3.Dizziness
4.Rash
5.Potentially Fatal: Anaphylaxis, agranulocytosis.
Contra-indications of Rabeprazole + ItoprideHypersensitivitySpecial Precautions while taking Rabeprazole + ItoprideN/APregnancy Related InformationUse with Caution Old Age Related InformationUse with Caution Breast Feeding Related InformationContra indicatedChildren Related InformationUse with Caution Indications for Rabeprazole + ItoprideGastro-oesophageal reflux diseaseInteractions for Rabeprazole + ItoprideN/ATypical Dosage for Rabeprazole + ItoprideAdult: Per capsule contains rabeprazole 20 mg and itopride 150 mg: 1 capsule once daily.Schedule of Rabeprazole + ItoprideN/AStorage Requirements for Rabeprazole + ItoprideN/AEffects of Missed Dosage of Rabeprazole + ItoprideN/AEffects of Overdose of Rabeprazole + ItoprideN/ARabeprazole
About RabeprazoleBenzimidazole derivative, Proton Pump Inhibitor, Antiulcer.Mechanism of Action of RabeprazoleRabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.Pharmacokinets of RabeprazoleAbsorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Rabeprazole sodium is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.Onset of Action for Rabeprazole1hourDuration of Action for Rabeprazole1 dayHalf Life of Rabeprazole1 - 2 hoursSide Effects of Rabeprazole1. Diarrhoea
2. Nausea
3. Headache
4. Vomiting
5. Abdominal pain
6. Dizziness
7. Flatulence
8. Constipation
9. Dyspepsia
10. Flu like syndrome
11. Insomnia
12. Back pain
13. Cough
14. Rhinitis
15. Pharyngitis
16. Rash
Contra-indications of Rabeprazole1. Hypersensitivity to Rabeprazole sodiumSpecial Precautions while taking Rabeprazole1. Hepatic impairment
2. Monitor gastric malignancy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Rabeprazole1. Active Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Erosive Gastroesophageal reflux disease
Interactions for RabeprazoleKetoconazole : Coadministration of rabeprazole sodium results in a 33% decrease in ketoconazole levels.
Digoxin : Increase in trough digoxin levels in normal subjects.
Typical Dosage for RabeprazoleOral
Adult: 10 - 20 mg / day drug to be taken before breakfast.
Duodenal ulcer: 20 mg / day in the morning for 1 month if needed dose can be continuing for 1more month.
Benign Gastric ulcer: 20 mg / day in the morning for 6 weeks if needed dose can be continuing for 6 more weeks.
Zollinger- Ellison syndrome: Initial dose: 60 mg / day if needed increase the dose up to 120 mg / day in 2 divided doses.
Erosive Gastroesophageal reflux disease: 20mg / day for 1-2 months.
Gastroesophageal reflux disease long term management: 10-20 mg once daily before breakfast for 1 year
Children: not recommended
Schedule of RabeprazoleHStorage Requirements for RabeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RabeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RabeprazoleGive supportive measures and symptomatic treatment.Itopride
About ItoprideDopamine(D2) antagonist, a prokinetic benzamide derivative, Motility stimulant.Mechanism of Action of ItoprideItopride has three way action. It inhibits the dopamine D2 receptor at the parasympathetic nerve ends.It increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the oesophageal and gastrointestinal peristalsis, increases the lower oesophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Itopride exerts anti-emetic actions because of its dopamine D2 receptor antagonistic action at CTZ.
Pharmacokinets of ItoprideAbsorption: it is orally well absorbed after oral administration.Metabolism: Itopride undergoes extensive hepatic metabolism.
Onset of Action for ItoprideN/ADuration of Action for ItoprideN/AHalf Life of Itopride5 - 6 hoursSide Effects of Itopride1.Diarrhoea
2.Abdominal pain
3.Headache
4.Constipation
5.Irritated feeling
6.Giddiness
Contra-indications of Itopride1.Hypersensitivity to Itopride
2.Gastrointestinal haemorrhage
3.Mechanical obstruction or perforation
Special Precautions while taking ItoprideN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below12 years: Contraindicated
Indications for Itopride1.Gastro oesophageal reflux diseases
2.Diabetic Gastroparesis
3.Non ulcer dyspepsia
4.Chronic gastritis
Interactions for ItoprideCisapride, atropine.
Typical Dosage for ItoprideAdult-Oral: 50 mg 3 times daily taken before each meal
Schedule of ItoprideN/AStorage Requirements for ItoprideStore the drug below 30 degree C. Protect from heat and light.Effects of Missed Dosage of ItoprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ItoprideGive supportive measures and symptomatic treatment.Home Delivery for Rabeprazole + Itopride in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rabeprazole + itopride.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rabeprazole + itopride and other medicines and health products. Home delivery services for rabeprazole + itopride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take rabeprazole + itopride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rabeprazole + itopride before they complete the sale. You can get this information while placing the order for rabeprazole + itopride with the pharmacy.
Rabeprazole + Itopride is a generic medicine name and there are several brands available for it. Some of the brands for rabeprazole + itopride might be better known than rabeprazole + itopride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rabeprazole + itopride in stock, you can ask for one of the branded alternatives for rabeprazole + itopride.
