Dexrabeprazole Pharmacology

Dexrabeprazole

About Dexrabeprazole
Dexrabeprazole is the R+-isomer of racemate rabeprazole that is more effective than the recemate and s-rabeprazole.
Mechanism of Action of Dexrabeprazole
Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell.
Pharmacokinets of Dexrabeprazole
1.Absorption: Oral bioavailability: about 52% and peak plasma concentrations are reached about 3.5 hr after oral admin.
2.Distribution: Protein-binding: 97%.
3.Metabolism: Extensively metabolised in the liver by cytochrome P450 isoenzymes.
4.Excretion: Metabolites are mainly excreted in the urine (90%).
Onset of Action for Dexrabeprazole
1 hr.
Duration of Action for Dexrabeprazole
24 hr.
Half Life of Dexrabeprazole
About 1 hr.
Side Effects of Dexrabeprazole
1.Nausea
2.Headache
3.Diarrhoea nausea
4.Rhinitis
5.Abdominal pain
6.Asthenia
7.Flatulence
8.Pharyngitis
9.Nausea&vomiting
10.Non-specific pain-back pain
11.Dizziness
12.Flu syndrome
13.Infection
14.Cough
15.Constipation
16.Insomnia
Contra-indications of Dexrabeprazole
N/A
Special Precautions while taking Dexrabeprazole
1.Caution required in administration to patient with severe hepatic dysfunction.
2.Gastric or oesophageal malignancy should be excluded.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
>12yrs use with caution
NEONATES>>Contraindicated
Indications for Dexrabeprazole
1.Gastroesophageal reflux disease (GERD)
2.Gastric and duodenal ulcer
3.Acid peptic disease

Interactions for Dexrabeprazole
1.Dexrabeprazole Sodium can interact with blood thinners.
2.It produce a intensive increase in drugs whose absorption is pH dependent (e.g digoxin, ketoconazole)

Typical Dosage for Dexrabeprazole
Adults- 10 mg once daily for 4-8 weeks depending upon condition and response. Maintenance ? 5 -10 mg once daily.
Schedule of Dexrabeprazole
H
Storage Requirements for Dexrabeprazole
Store it at room temperature.
Effects of Missed Dosage of Dexrabeprazole
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Effects of Overdose of Dexrabeprazole
Seek emergency medical attention.

Home Delivery for Dexrabeprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dexrabeprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dexrabeprazole and other medicines and health products. Home delivery services for dexrabeprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dexrabeprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexrabeprazole before they complete the sale. You can get this information while placing the order for dexrabeprazole with the pharmacy.

Dexrabeprazole is a generic medicine name and there are several brands available for it. Some of the brands for dexrabeprazole might be better known than dexrabeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexrabeprazole in stock, you can ask for one of the branded alternatives for dexrabeprazole.