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- Pharmacology For Terbutaline + Ambroxol + Etophylline
Terbutaline + Ambroxol + Etophylline Pharmacology
Terbutaline + Ambroxol + Etophylline
About Terbutaline + Ambroxol + EtophyllineN/AMechanism of Action of Terbutaline + Ambroxol + EtophyllineN/APharmacokinets of Terbutaline + Ambroxol + EtophyllineN/AOnset of Action for Terbutaline + Ambroxol + EtophyllineN/ADuration of Action for Terbutaline + Ambroxol + EtophyllineN/AHalf Life of Terbutaline + Ambroxol + EtophyllineN/ASide Effects of Terbutaline + Ambroxol + EtophyllineN/AContra-indications of Terbutaline + Ambroxol + EtophyllineN/ASpecial Precautions while taking Terbutaline + Ambroxol + EtophyllineN/APregnancy Related InformationContra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContra indicatedChildren Related InformationUse with cautionIndications for Terbutaline + Ambroxol + Etophylline1.Acute attacks or status asthamticus
2.Relief of dyspnoea
3.Bronchospasm in other respiratory disorders like copd
4.Emphysema.
Interactions for Terbutaline + Ambroxol + EtophyllineN/ATypical Dosage for Terbutaline + Ambroxol + Etophylline1.Adult:One tablet (Terbutaline2mg+ambroxol30mg+etophylline100mg) thrise a day
2.Children :Syrup(Terbutaline2mg+ambroxol30mg+etophylline100mg per 5ml)
7-15 years: 5-10ml 2-3 times a day (1-2 teaspoonfuls).
3-6 years : 2.5-5 ml 2-4 times a day (1/2-1 teaspoonful).
2 years : 2.5 ml 2-3 times a day (1/2 teaspoonful)
Schedule of Terbutaline + Ambroxol + EtophyllineN/AStorage Requirements for Terbutaline + Ambroxol + EtophyllineN/AEffects of Missed Dosage of Terbutaline + Ambroxol + EtophyllineN/AEffects of Overdose of Terbutaline + Ambroxol + EtophyllineN/ATerbutaline
About TerbutalineA ?2-adrenergic agonist,a fast-acting bronchodilator, Tocolytic,Anti asthma.Mechanism of Action of TerbutalineTerbutaline is a ?2 receptor agonist. Terbutaline directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
Tocolytic action: In premature labour Terbutaline relaxes uterine smooth muscles and inhibits uterine contractions.
Pharmacokinets of TerbutalineAbsorption: It is partially absorbed (about 33- 50%) after oral administration
Distribution: It is widely distributed in the body.
Metabolism: It is partially metabolised in the liver to inactive compounds.
Excretion: Drug and its metabolites are excreted mainly in urine.
Onset of Action for Terbutaline30 minutes (oral), 15 minutes (subcutaneous), 5-30 minutes (inhalation)Duration of Action for Terbutaline4- 8 hours (oral), 1.5-4 hours (subcutaneous), 3- 6 hours (inhalation).Half Life of TerbutalineN/ASide Effects of Terbutaline1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Dry and irritated nose (inhalation)
15. Hypokalaemia (high dose)
Contra-indications of Terbutaline1. Hypersensitivity to Terbutaline and other sympathomimetic amines.Special Precautions while taking Terbutaline1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution
CHILDREN Below 12 years : contraindicated
NEONATES: contraindicated
Indications for Terbutaline1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for TerbutalineOther Sympathomimetic bronchodilators or epinephrine: Combined effect on the cardiovascular system may be deleterious to the patient.
MAOIs and TCAs: Effect of terbutaline on vascular system may be potentiated.
Beta-adrenergic blocking agents: Block the pulmonary effect of terbutaline and may produce severe asthmatic attacks in asthmatic patients.
Beclomethasone, Theophylline: Synergy when used with these agents.
Food: Reduces bioavailability of terbutaline.Typical Dosage for TerbutalineAdult:
Oral: Initial dose: 7.5 mg / day in 3 divided doses, if needed dose can be increased to 15mg /day in 3 divided doses.
Subcutaneous /Intramuscular/slow IV infusion: 250 - 500mcg 3 - 4 times daily
Aerosol inhalation: 250 - 500mcg every 6 - 8 hours
Nebulised solution inhalation: 5 - 10 mg every 6 - 12 hours.
Children:
Oral: Initial dose: 2.5 mg in 2-3 times daily
Subcutaneous /Intramuscular/slow IV infusion: 10mcg /kg body weight dose can be increased to 300 mcg / day
Aerosol inhalation: 250 - 500mcg every 6 - 8 hours
Nebulised solution inhalation: 2 - 5 mg every 6 - 12 hours.
Premature labor (IV): Initial dose: 10mcg/minute and dose can be repeated until effective therapeutic response is obtained. Maximum dose: 80mcg/minute. Maintenance dose (IV dosage): Minimum effective dose for 4 hours.
Schedule of TerbutalineHStorage Requirements for TerbutalineStore at 15 - 30 degree C. Protect from heat and light.Effects of Missed Dosage of TerbutalineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TerbutalineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.Ambroxol
About AmbroxolActive N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.Mechanism of Action of AmbroxolAmbroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.Pharmacokinets of AmbroxolN/AOnset of Action for AmbroxolN/ADuration of Action for AmbroxolN/AHalf Life of AmbroxolN/ASide Effects of Ambroxol1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.Contra-indications of AmbroxolHypersensitivity to the Ambroxol hydrochloride or Bromhexine.Special Precautions while taking Ambroxol1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ambroxol1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.Interactions for AmbroxolN/ATypical Dosage for AmbroxolOral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of AmbroxolHStorage Requirements for AmbroxolStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of AmbroxolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmbroxolProvide symptomatic treatment and supportive measures.Etophylline
About EtophyllinePurine (Xanthine )derivative:Theophylline analogs & derivatives, Bronchodilator Agents ,Antiasthmatic.Mechanism of Action of EtophyllineEtophylline is the ethyl salt of Theophylline.It inhibit phosphodiesterase enzyme which degrades cyclic nucleotides intracellularly and it results the cyclic AMP accumulation in the cell. This cause bronchodialatation, cardiac stimulation and vasodilatation. This drug release calcium from sarcoplasmic reticulam, especially in cardiac muscles and results increased cardiac muscle contraction. This drug also blocks adenosine receptors (adenosine acts as a local mediator in CNS & CVS and other organs- which contracts smooth muscles, especially in bronchi, blood vessels etc). This results bronchodialatation and vasodialatation.Pharmacokinets of EtophyllineAbsorption- Well absorbed after oral administration. Rapidly and well absorbed after intravenous administration
Distribution- Widely distributed in the body. 40% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites by demethylation and oxidation. 1-methyluric acid is its metabolite
Excretion- Excreted through urine
Onset of Action for Etophylline15 to 60 min. after oral administration and 15 minutes after intravenous administrationDuration of Action for EtophyllineN/AHalf Life of EtophyllineIts plasma half life is 8 hrsSide Effects of Etophylline1. Upset stomach
2. Stomach pain
3. Diarrhea
4. Headache
5. Restlessness
6. Insomnia
7. Irritability
8. Vomiting
9. Increased or rapid heart rate
10. Irregular heartbeat
11. Seizures
12. Skin rash
Contra-indications of Etophylline1. Hypersensitivity to the drug
2. Peptic ulcer
3. Underlying seizure disorders
Special Precautions while taking Etophylline1.Heart disease
2.Liver disease
3.Peptic ulcer
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Etophylline1. Asthma
2. Chronic obstructive pulmonary disease
3. Chronic bronchitis
4. Emphysema
5. It can be used in premature infants who stop breathing
Interactions for EtophyllineN/ATypical Dosage for EtophyllineUp to 1.5 g / daySchedule of EtophyllineN/AStorage Requirements for EtophyllineN/AEffects of Missed Dosage of EtophyllineN/AEffects of Overdose of EtophyllineN/AHome Delivery for Terbutaline + Ambroxol + Etophylline in Your City
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