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- Pharmacology For Doxofylline + Salbutamol
Doxofylline + Salbutamol Pharmacology
Doxofylline + Salbutamol
About Doxofylline + SalbutamolN/AMechanism of Action of Doxofylline + SalbutamolN/APharmacokinets of Doxofylline + SalbutamolN/AOnset of Action for Doxofylline + SalbutamolN/ADuration of Action for Doxofylline + SalbutamolN/AHalf Life of Doxofylline + SalbutamolN/ASide Effects of Doxofylline + SalbutamolN/AContra-indications of Doxofylline + SalbutamolN/ASpecial Precautions while taking Doxofylline + SalbutamolN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution,Below 6 years:Contra indicatedIndications for Doxofylline + SalbutamolFor symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD.Interactions for Doxofylline + SalbutamolN/ATypical Dosage for Doxofylline + SalbutamolN/ASchedule of Doxofylline + SalbutamolN/AStorage Requirements for Doxofylline + SalbutamolN/AEffects of Missed Dosage of Doxofylline + SalbutamolN/AEffects of Overdose of Doxofylline + SalbutamolN/ADoxofylline
About DoxofyllineA xanthine derivative, Phosphodiesterase inhibitor, Antiasthmatic,antitussive and bronchodilator.Mechanism of Action of DoxofyllineSimilar efficacy to theophylline but with significantly less side effects.
Its mechanism of action is related to the inhibition of phosphodiesterase activities, resulting in bronchodilating effects. Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects.
Pharmacokinets of DoxofyllineN/AOnset of Action for DoxofyllineN/ADuration of Action for DoxofyllineN/AHalf Life of DoxofyllineN/ASide Effects of Doxofylline1.Nausea
2.Vomiting
3.Tremor
4.Palpitation.
Contra-indications of Doxofylline1.Hypersensitivity
2.Myocardial infaraction
3.Doxofilline and other methyxanthine derivatives.
4.Methyxanthines are not recommended for therapy of asthma exacerbations
Special Precautions while taking DoxofyllineShould be used cautiously in patients with active ulcer disease, asthma, bts bleeding disorders, mild renal impairment. Renal toxicity may occurs, caution should be exercised when know renal dysfunction or H/o of renal disease.Pregnancy Related InformationUse with Caution Old Age Related InformationN/ABreast Feeding Related InformationUse with Caution Children Related InformationN/AIndications for DoxofyllineBronchial Asthma and COPD.Interactions for DoxofyllineCocomitant administration with other xanthines derivatives, Phenytoin.Typical Dosage for DoxofyllineAdult:400mg once a day. Single dose, administration in the evening reduces nocturnal, symptoms and helps to keep the patients complaint free during the day.
400mg twice daily is recommended on the basis of the clinical response.
Schedule of DoxofyllineN/AStorage Requirements for DoxofyllineN/AEffects of Missed Dosage of DoxofyllineN/AEffects of Overdose of DoxofyllineN/ASalbutamol
About SalbutamolBeta2-Adrenergic Agonist, Phenethylamine derivative, Bronchodilator(Antiasthma), uterine relaxant.Mechanism of Action of SalbutamolSalbutamol is a short acting ?2 receptor agonist. It selectively stimulates ?2 receptors present in airway, Uterus, and Vascular Smooth muscles. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salbutamol can inhibit the broncho-constriction produced by inflammatory mediators. Salbutamol is effective in the management of preterm labour.
Pharmacokinets of SalbutamolAbsorption: It is well absorbed after oral administration.
Distribution: Salbutamol does not cross the blood brain barrier.
Metabolism: It is metabolised to inactive metabolites in the liver
Excretion: Salbutamol is excreted primarily in the urine and small amount in the faeces.
Onset of Action for Salbutamol15 - 30 minutesDuration of Action for Salbutamol6 - 12 hoursHalf Life of Salbutamol4 hoursSide Effects of Salbutamol1. Drowsiness
2. Headache
3. Dizziness
4. Nervousness
5. Tremor
6. Weakness
7. Palpitations
8. Tachycardia
9. Arrhythmia
10. Vomiting
11. Nausea
12. Heartburn
13. Diaphoresis
14. Hypokalaemia (high dose)
Contra-indications of Salbutamol1.Hypersensitivity to Salbutamol and other sympathomimetic amines.Special Precautions while taking Salbutamol1. Myocardial insufficiency
2. Arrhythmia
3. Hypertension
4. Hyperthyroidism
5. Epilepsy
6. Diabetes
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution
Below 6 years: contraindicatedIndications for Salbutamol1. Obstructive airway diseases
2. Acute Bronchospasm
3. Status asthmaticus
4. Premature labour
Interactions for SalbutamolBeclomethasone, Theophylline: Enhances respiratory function.
Beta-blockers: Inhibit bronchodilator effect.
Diuretics and Xanthines: Increased risk of hypokalemia.
Digitalis: Increased risk of digitalis toxicity when salbutamol is given in hilgh doses due to hypokalaemia.Typical Dosage for SalbutamolAdult:
Oral:
Immediate release tablet: 2 - 4 mg every 6 - 8 hours daily, maximum dose 32mg / day
Sustained release tablets: 8 mg / day in 2 divided doses and if sufficient response does not obtained then dose can be gradually increased to 16mg / day in 2 divided doses
Children: 6 - 14 years
Syrup: 6 - 8mg / day in 3 - 4 divided doses and if needed dose can be increased maximum up to 24mg / day
Uterine Relaxant: (I.V) 4 to 32 mcg/minutes
Schedule of SalbutamolHStorage Requirements for SalbutamolStore at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of SalbutamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SalbutamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of drug can be reduced by administration of activated charcoal.Home Delivery for Doxofylline + Salbutamol in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including doxofylline + salbutamol.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for doxofylline + salbutamol and other medicines and health products. Home delivery services for doxofylline + salbutamol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take doxofylline + salbutamol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for doxofylline + salbutamol before they complete the sale. You can get this information while placing the order for doxofylline + salbutamol with the pharmacy.
Doxofylline + Salbutamol is a generic medicine name and there are several brands available for it. Some of the brands for doxofylline + salbutamol might be better known than doxofylline + salbutamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have doxofylline + salbutamol in stock, you can ask for one of the branded alternatives for doxofylline + salbutamol.
