Torasemide + Spironolactone Pharmacology

Torasemide + Spironolactone

About Torasemide + Spironolactone
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Mechanism of Action of Torasemide + Spironolactone
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Pharmacokinets of Torasemide + Spironolactone
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Onset of Action for Torasemide + Spironolactone
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Duration of Action for Torasemide + Spironolactone
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Half Life of Torasemide + Spironolactone
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Side Effects of Torasemide + Spironolactone
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Contra-indications of Torasemide + Spironolactone
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Special Precautions while taking Torasemide + Spironolactone
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Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Not recommended
Indications for Torasemide + Spironolactone
Oedema associated with various disorders.
Interactions for Torasemide + Spironolactone
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Typical Dosage for Torasemide + Spironolactone
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Schedule of Torasemide + Spironolactone
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Storage Requirements for Torasemide + Spironolactone
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Effects of Missed Dosage of Torasemide + Spironolactone
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Effects of Overdose of Torasemide + Spironolactone
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About
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Mechanism of Action of
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Onset of Action for
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Half Life of
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Contra-indications of
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Special Precautions while taking
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Children Related Information
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Indications for
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Typical Dosage for
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Schedule of
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Spironolactone

About Spironolactone
Selective Aldosterone antagonist, antiandrogen, Potassium-sparing diuretic.
Mechanism of Action of Spironolactone
Spironolactone is a steroid with structural similarity to aldosterone which exerts it`s pharmacological actions by acting as a competitive antagonist of aldosterone; in the distal part of nephron (late distal tubule and collecting duct). It prevents potassium secretion and decreases sodium reabsorption. It binds with minerelocorticoid receptor from the interstitial side and inhibits formation of aldosterone induced proteins competitively and thus increases sodium excretion and decreases potassium excretion. It increases Ca excretion also. It also blocks the effects of aldosterone on arteriolar smooth muscles and reduces peripheral resistance. It prevents aldosterone induced sodium and water retention and thus reduces blood volume and used as an effective diuretic in treatment of hypertension and also used to reduce potassium loss associated with the use of other diuretics. It is an effective diuretic in the management of congestive heart failure for mobilization of oedema fluid. It prevents aldosterone induced myocardial fibrosis and disease progression in patients with congestive heart failure.
Pharmacokinets of Spironolactone
Spironolactone is a steroid with structural similarity to aldosterone which exerts it`s pharmacological actions by acting as a competitive antagonist of aldosterone; in the distal part of nephron (late distal tubule and collecting duct). It prevents potassium secretion and decreases sodium reabsorption. It binds with minerelocorticoid receptor from the interstitial side and inhibits formation of aldosterone induced proteins competitively and thus increases sodium excretion and decreases potassium excretion. It increases Ca excretion also. It also blocks the effects of aldosterone on arteriolar smooth muscles and reduces peripheral resistance. It prevents aldosterone induced sodium and water retention and thus reduces blood volume and used as an effective diuretic in treatment of hypertension and also used to reduce potassium loss associated with the use of other diuretics. It is an effective diuretic in the management of congestive heart failure for mobilization of oedema fluid. It prevents aldosterone induced myocardial fibrosis and disease progression in patients with congestive heart failure.
Onset of Action for Spironolactone
1 to2 days
Duration of Action for Spironolactone
2 to 3days
Half Life of Spironolactone
N/A
Side Effects of Spironolactone
1.Headache
2.Drowsiness
3.Nausea
4.Duodenal and gastric bleeding
5.Ulceration
6.Gynecomastia
7.Menstrual irregularities
8.Testicular atrophy
9.Ataxia
10.Impotence
11.Diarrhoea
12.Vomiting
13.Hyper kalemia
14.Hyponatraemia
15.Agranulocytosis
16.Altered levels of blood urea nitrogen
17.Gastro intestinal disturbances
18.Rashes
19.Ototoxicity



Contra-indications of Spironolactone
1.Hypersensitivity to the drug
2.Hyper kalaemia
3.Anuria
4.Acute and progressive renal insufficiency

Special Precautions while taking Spironolactone
1.Renal impairment
2.Hepatic impairment
3.Fluid and electrolyte imbalance



Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Spironolactone
1.Hypertension
2.Oedema
3.Diagnosis of primary hyperaldosteronism
4.Hirsutism
5.Premenstrual syndrome
6.Acne
7.Seborrhoeics

Interactions for Spironolactone
ACE Inhibitors: Enhanced hypotensive effect; significant hyperkalaemia may occur.
Digitalis glycosides: Interaction is complex and may result in increased serum digoxin levels & subsequent digitalis toxicity.
Cyclosporin: Increased risk of hyperkalaemia.
Potassium Preparations: May result in hyperkalaemia, possibly with cardiac arrhythmias or cardiac arrest, especially in patients with impaired renal functions.
Salicylates: Diuretic effects reduced by salicylates.
Carbenoxolone: Ulcer healing effect antagonised by spironolactone.
Food: Increased absorption of spironolactone.
Lab tests: Interferes with radio-immuno assay for measuring digoxin, resulting in falsely elevated serum digoxin.
Typical Dosage for Spironolactone
Hypertension: 50 to 100mg/day in divided doses.
Oedema: 25 to 200mg/day in divided doses.
Diagnosis of primary hyperaldosteronism: 400mg/day (short test) or up to four weeks (long test)
Hirsutism: 25 to 200mg/day in divided doses.
Premenstrual syndrome: 25mg four times on fourteenth day of menstrual cycle.
Acne: 100mg/day.

Schedule of Spironolactone
H
Storage Requirements for Spironolactone
Store at room temperature in a well closed container and protects from light.
Effects of Missed Dosage of Spironolactone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Spironolactone
Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and support electrolyte balance. Reduce serum potassium with I.V. sodium bicarbonate or glucose with insulin. Potassium level is also reduced by a cation exchange resins like sodium polystyrene sulfonate given orally or as retention enema.

Home Delivery for Torasemide + Spironolactone in Your City

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Torasemide + Spironolactone is a generic medicine name and there are several brands available for it. Some of the brands for torasemide + spironolactone might be better known than torasemide + spironolactone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have torasemide + spironolactone in stock, you can ask for one of the branded alternatives for torasemide + spironolactone.