Ampicillin Pharmacology


About Ampicillin
Semisynthetic Broad spectrum beta-lactam antibiotic, Aminobenzylpenicillin Antibiotic
Mechanism of Action of Ampicillin
Ampicillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Ampicillin is active against both gram positive and gram negative organism.
Pharmacokinets of Ampicillin
Absorption .It is readily but incompletely absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly through bile and small amount excreted through urine and breast milk.
Onset of Action for Ampicillin
30 minutes
Duration of Action for Ampicillin
6 - 8 hours
Half Life of Ampicillin
90 minutes
Side Effects of Ampicillin
Contra-indications of Ampicillin
1.Hypersensitivity to Penicillin
Special Precautions while taking Ampicillin
2.Lymphatic leukaemia
3.HIV infections
4.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Ampicillin
1.Urinary tract infections
3. Meningitis
5. Respiratory tract infections
7.Soft tissue infections
8.Otitis media
11.Biliary tract nfections
17.Paratyphoid fever
Interactions for Ampicillin
Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Allopurinol: Increases risk of ampicillin induced skin rash.
Beta blockers: Oral penicillin like ampicillin may reduce bio-availability of atenolol. Also they may potentiate anaphylatic reactions with penicillin.
Probenecid: Increases blood levels.
Erythromycin, Tetracycline: Reduce efficacy.
Clavulinic Acid: Synergy.
Food: Interferes with absorption.
Typical Dosage for Ampicillin
Bacterial infections: 250 - 500 mg four times a day depending on the severity of infection
Typhoid and paratyphoid fever: 1 - 2 g four times daily

Bacterial infections: 125 - 250 mg four times a day depending on the severity of infection
Schedule of Ampicillin
Storage Requirements for Ampicillin
Store the drug at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children
Effects of Missed Dosage of Ampicillin
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and continue the regular schedule. Do not double the dose.
Effects of Overdose of Ampicillin
Give supportive measures and symptomatic treatment. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Ampicillin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ampicillin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ampicillin and other medicines and health products. Home delivery services for ampicillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ampicillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ampicillin before they complete the sale. You can get this information while placing the order for ampicillin with the pharmacy.

Ampicillin is a generic medicine name and there are several brands available for it. Some of the brands for ampicillin might be better known than ampicillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ampicillin in stock, you can ask for one of the branded alternatives for ampicillin.