Miconazole + Ornidazole Pharmacology

Miconazole + Ornidazole

About Miconazole + Ornidazole
N/A
Mechanism of Action of Miconazole + Ornidazole
N/A
Pharmacokinets of Miconazole + Ornidazole
N/A
Onset of Action for Miconazole + Ornidazole
N/A
Duration of Action for Miconazole + Ornidazole
N/A
Half Life of Miconazole + Ornidazole
N/A
Side Effects of Miconazole + Ornidazole
N/A
Contra-indications of Miconazole + Ornidazole
N/A
Special Precautions while taking Miconazole + Ornidazole
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Miconazole + Ornidazole
Vaginal infections caused by Candida species, Torulopsis species, Trichomonas vaginalis and certain gram positive and gram negative microorganisms.
Interactions for Miconazole + Ornidazole
N/A
Typical Dosage for Miconazole + Ornidazole
N/A
Schedule of Miconazole + Ornidazole
N/A
Storage Requirements for Miconazole + Ornidazole
N/A
Effects of Missed Dosage of Miconazole + Ornidazole
N/A
Effects of Overdose of Miconazole + Ornidazole
N/A

Miconazole

About Miconazole
An imidazole derivative, Broad spectrum Antifungal.
Mechanism of Action of Miconazole
Miconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis
Pharmacokinets of Miconazole
Absorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.
Onset of Action for Miconazole
N/A
Duration of Action for Miconazole
N/A
Half Life of Miconazole
1 day
Side Effects of Miconazole
1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis
Contra-indications of Miconazole
1.Hypersensitivity to Miconazole and other Azole antifungals
Special Precautions while taking Miconazole
1.Hepatic dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Miconazole
1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitis
Interactions for Miconazole
Benzoyl peroxide: Antibacterial synergism.
Typical Dosage for Miconazole
Adult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days

CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part

Schedule of Miconazole
H
Storage Requirements for Miconazole
The drug should be stored at 15 - 30 degree C.
Effects of Missed Dosage of Miconazole
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Miconazole
Give supportive measures and treatment.

Ornidazole

About Ornidazole
A nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.
Mechanism of Action of Ornidazole
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of Ornidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for Ornidazole
Within 2 hours
Duration of Action for Ornidazole
14hours
Half Life of Ornidazole
12 to 14 hours
Side Effects of Ornidazole
1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.Vertigo
Contra-indications of Ornidazole
1.Hypersensitivity to the drug or other imidazoles
Special Precautions while taking Ornidazole
1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related Information
Use with caution
First trimester: contra indicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Ornidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for Ornidazole
N/A
Typical Dosage for Ornidazole
Amoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of Ornidazole
H
Storage Requirements for Ornidazole
Store at cool dry place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Ornidazole
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ornidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics.

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