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- Pharmacology For Ebastine + Montelukast
Ebastine + Montelukast Pharmacology
Ebastine + Montelukast
About Ebastine + MontelukastN/AMechanism of Action of Ebastine + MontelukastN/APharmacokinets of Ebastine + MontelukastN/AOnset of Action for Ebastine + MontelukastN/ADuration of Action for Ebastine + MontelukastN/AHalf Life of Ebastine + MontelukastN/ASide Effects of Ebastine + Montelukast1.Cough
2.Dizziness
3.Headache
4.Indigestion
5.Nausea
6.Stomach upset or pain
7.Stuffy nose
8.Tiredness
9.Trouble sleeping
10.Weakness
Contra-indications of Ebastine + MontelukastN/ASpecial Precautions while taking Ebastine + MontelukastN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ebastine + Montelukast1.Allergic conditions including rhinitis and pruritic skin disorders
2.Long?term treatment of asthma
Interactions for Ebastine + MontelukastN/ATypical Dosage for Ebastine + MontelukastN/ASchedule of Ebastine + MontelukastN/AStorage Requirements for Ebastine + MontelukastStore Singulair at 77 ?F (25 ?C), brief storage permitted at 59 ? 86 ?F (15 ? 30 ?C). Store away from heat, moisture, and light. Keep out of the reach of children.Effects of Missed Dosage of Ebastine + MontelukastTake it as soon as you remember. However if it is almost time for the next dose, skip the Missed Dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.Effects of Overdose of Ebastine + MontelukastN/AEbastine
About EbastineSecond generation, long-acting and selective H1 antagonist, Non-sedative Antihistamine.Mechanism of Action of EbastineDrug and its active metabolite is selective peripheral histamine H1 receptor antagonist. Thus it prevents the attachment of histamine on receptors and its activation (Activation of receptors of histamine on various tissues produce various allergic symptoms e.g. Runny nose).Ebastine also has a specific inhibitory effect on Th2-type cytokine production and inhibit T cell migration and pro-inflammatory cytokine production by T cells and macrophagesPharmacokinets of EbastineAbsorption - Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. >95% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites by N-dealkylation and hydroxylation.Carebastine is its active metabolite.
Excretion- Excreted through urine
Onset of Action for EbastineN/ADuration of Action for EbastineN/AHalf Life of EbastineIts plasma half life is 15-19 hrsSide Effects of Ebastine1. Headache
2. Dry mouth
3. Drowsiness
4. Pharyngitis
5. Abdominal pain
6. Dyspepsia
7. Asthenia
8. Epistaxis
9. Rhinitis
10. Sinusitis
11. Nausea
12. InsomniaContra-indications of Ebastine1. Hypersensitivity to Ebastine or any of its ingredients
2. Cardiac arrhythmia
Special Precautions while taking Ebastine1. Long QT syndrome
2. Hypokalemia
3. Hepatic impairment
4. Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Ebastine1. Seasonal and perennial allergic rhinitis
2. Idiopathic chronic urticaria
3. T cell-mediated allergic inflammatory disorders (asthma, atopic dermatitis)
4. Th2 -type autoimmune diseases
Interactions for EbastineKetoconazole / Erythromycin: When ebastine is given concomitantly a pharmacokinetic and pharmacodynamic interaction has been observed; an 18-19 msec (4.7%-5%) increase in QT has been reported with either combination.
Typical Dosage for EbastineOral-
Adult-10 mg once a day
Schedule of EbastineN/AStorage Requirements for EbastineStore below 25?C.Protect from light. Keep out of reach of childrenEffects of Missed Dosage of EbastineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doseEffects of Overdose of EbastineGive symptomatic and supportive treatmentMontelukast
About MontelukastLeukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.Mechanism of Action of MontelukastMontelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.
Pharmacokinets of MontelukastAbsorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.
Onset of Action for MontelukastN/ADuration of Action for MontelukastN/AHalf Life of Montelukast2.75 - 5.5 hoursSide Effects of Montelukast1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia
Contra-indications of Montelukast1.Hypersensitivity to Montelukast
2.Acute asthmatic attacksSpecial Precautions while taking MontelukastN/APregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationMay be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated
Indications for MontelukastAsthma.Interactions for MontelukastBarbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
Typical Dosage for MontelukastAdult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time
Schedule of MontelukastN/AStorage Requirements for MontelukastStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of MontelukastTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MontelukastGive supportive measures and symptomatic treatmentHome Delivery for Ebastine + Montelukast in Your City
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